Alan Dardik

About

Dr. Alan Dardik is a surgeon-scientist who harnesses the power of molecular biology to achieve a modern understanding of vascular disease and then use the basic science laboratory to ultimately benefit patients with vascular diseases. Dr. Dardik trained at Yale, the University of Pennsylvania, and the Johns Hopkins Hospital before his appointment to the Yale faculty in 2001. Dr. Dardik focuses his clinical practice on teaching; he was formerly the Chief of Vascular Surgery and the Chief of the Surgical service at VA Connecticut and received the C. Elton Cahow Award for Outstanding Faculty Teaching from Yale’s Department of Surgery and the Faculty Teaching Award from St. Mary’s Hospital. Dr. Dardik has served Yale’s Department of Surgery as a Vice Chair of Faculty Affairs, as well as an Interim Division Chief of Vascular and Endovascular Surgery. In 2025, Dr. Dardik joined the Icahn School of Medicine at Mount Sinai where he serves as the Vice Chair for Research as well as the Co-Director of the Jacobson Aortic Center in the Department of Surgery. The Dardik laboratory studies the healing and function of blood vessels, fistulae and vessel patches that are used in patients having vascular surgery. The laboratory is trying to understand the fundamental molecular mechanisms by which vein graft adaptation and arteriovenous fistula maturation result in positive remodeling and successful adaptation to the arterial environment, yet often proceed, in the long-term, to neointimal hyperplasia and failure. The laboratory has been funded from the NIH for over 20 years. Dr. Dardik is deeply committed to the training and mentoring of young investigators, especially those interested in becoming clinician-scientists; he has been a mentor to over 25 predoctoral students for MD, PhD, MD/PhD, and masters’ degrees, and to over 50 postdoctoral fellows, many of whom have entered academic careers. Dr. Dardik currently serves as the Editor-in-Chief for the newly launched journal JVS-Vascular Science; he has served as the President of the New England Society for Vascular Surgery, the Association of VA Surgeons, as well as the International Society for Vascular Surgery. Dr. Dardik has run several national and international meetings, including the Society for Vascular Surgery Vascular Research Initiatives Conference, and has served on numerous peer review committees including review for the NIH, the VA, the American Heart Association, and Vascular Cures. Dr. Dardik has edited several textbooks including “Vascular Surgery: A Global Perspective” and “Stem cell therapy for vascular diseases.”

Education

University of Pennsylvania School of Medicine
United States of America

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M.D.

University of Pennsylvania School of Medicine
United States of America

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Ph.D.

Yale University
United States of America

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B.S.

Publications

Sustained Tenascin-C Expression Drives Neointimal Hyperplasia and Promotes Aortocaval Fistula Failure.

Published by

American journal of physiology. Heart and circulatory physiology

Summary

journal-article

Recent Innovations and Advances in Arteriovenous Fistula Creation: A Narrative Review.

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Vascular investigation and therapy

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journal-article

Changes in vascular identity during vascular remodeling.

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JVS-vascular science

Summary

journal-article

Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling.

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Scientific reports

Summary

journal-article

A surgeon-scientist's approach to improving arteriovenous fistula patency.

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JVS-vascular science

Summary

journal-article

Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms.

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JVS-vascular science

Summary

journal-article

Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia.

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American journal of physiology. Heart and circulatory physiology

Summary

journal-article

A central arteriovenous fistula reduces systemic hypertension in a mouse model.

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JVS-vascular science

Summary

journal-article

Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

Early thrombus formation is required for eccentric and heterogeneous neointimal hyperplasia under disturbed flow.

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Journal of thrombosis and haemostasis : JTH

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journal-article

Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation.

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Annals of vascular surgery

Summary

journal-article

The Society for Vascular Surgery 2023 von Liebig lecture: The joys of being a surgeon-scientist.

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JVS-vascular science

Summary

journal-article

Rates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020.

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JAMA surgery

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journal-article

Computer Science meets Vascular Surgery: Keeping a pulse on artificial intelligence.

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Seminars in vascular surgery

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review

EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model.

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JVS-vascular science

Summary

journal-article

Sex Hormones Impact Early Maturation and Immune Response in the Arteriovenous Fistula Mouse Model.

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American journal of physiology. Heart and circulatory physiology

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journal-article

Gender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020.

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JAMA network open

Summary

journal-article

Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury.

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Molecular biology reports

Summary

journal-article

Bioinformatics identifies predictors of arteriovenous fistula maturation.

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J Vasc Access

Summary

journal-article

Reemerging from the pandemic: How do we restart?

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Journal of vascular surgery

Summary

journal-article

Arteriovenous Fistula-induced Cardiac Remodeling Shows Cardioprotective Features in Mice.

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JVS-vascular science

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journal-article

PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae.

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Frontiers in cardiovascular medicine

Summary

journal-article

Arteriovenous Fistula-induced Cardiac Remodeling Shows Cardioprotective Features in Mice.

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JVS-vascular science

Summary

journal-article

Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia

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Cells

Summary

journal-article

Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae

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The Journal of Surgical Research

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journal-article

Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency

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Science Translational Medicine

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journal-article

A mouse model of stenosis distal to an arteriovenous fistula recapitulates human central venous stenosis.

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JVS-vascular science

Summary

journal-article

TGFβ (Transforming Growth Factor-Beta)-Activated Kinase 1 Regulates Arteriovenous Fistula Maturation.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice.

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JVS-Vascular Science

Summary

journal-article

Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing.

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Regenerative medicine

Summary

journal-article

Venous Mechanical Properties After Arteriovenous Fistulae in Mice.

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The Journal of surgical research

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journal-article

Reduced patency in left-sided arteriovenous grafts in a porcine model.

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Journal of vascular surgery

Summary

journal-article

Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency.

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Scientific reports

Summary

journal-article

Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis.

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Journal of visualized experiments : JoVE

Summary

journal-article

Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency.

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Vascular investigation and therapy

Summary

journal-article

Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency.

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Vascular Investigation and Therapy

Summary

journal-article

Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

The potential and limitations of induced pluripotent stem cells to achieve wound healing.

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Stem cell research & therapy

Summary

journal-article

Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells.

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American journal of physiology. Cell physiology

Summary

journal-article

Molecular identity of arteries, veins, and lymphatics.

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Journal of vascular surgery

Summary

journal-article

Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research.

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Stem cell research & therapy

Summary

journal-article

A Murine Model of Hind Limb Ischemia to Study Angiogenesis and Arteriogenesis.

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Methods in molecular biology (Clifton, N.J.)

Summary

journal-article

The Mouse Aortocaval Fistula Model with Intraluminal Drug Delivery.

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Methods in molecular biology (Clifton, N.J.)

Summary

journal-article

CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty.

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Arteriosclerosis, thrombosis, and vascular biology

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journal-article

Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency.

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Scientific reports

Summary

journal-article

Polyester vascular patches acquire arterial or venous identity depending on their environment.

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Journal of biomedical materials research. Part A

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journal-article

Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?

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Annals of Vascular Diseases

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journal-article

Patch Angioplasty in the Rat Aorta or Inferior Vena Cava.

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Journal of visualized experiments : JoVE

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journal-article

Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation.

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Annals of vascular surgery

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journal-article

Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia.

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Scientific reports

Summary

journal-article

Future research directions to improve fistula maturation and reduce access failure.

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Seminars in vascular surgery

Summary

journal-article

Radial artery deviation and reimplantation inhibits venous juxta-anastomotic stenosis and increases primary patency of radial-cephalic fistulas for hemodialysis.

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Journal of vascular surgery

Summary

journal-article

Pericardial patch venoplasty heals via attraction of venous progenitor cells.

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Physiological Reports

Summary

journal-article

Delivery of mesenchymal stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcers.

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Regenerative medicine

Summary

journal-article

Membrane-mediated regulation of vascular identity.

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Birth defects research. Part C, Embryo today : reviews

Summary

journal-article

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium.

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Journal of visualized experiments : JoVE

Summary

journal-article

Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase.

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Journal of vascular surgery

Summary

journal-article

Disturbed shear stress reduces Klf2 expression in arterial-venous fistulae in vivo.

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Physiological Reports

Summary

journal-article

Pretreatment of pericardial patches with antibiotics does not alter patch healing in vivo.

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Journal of vascular surgery

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journal-article

Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro.

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Journal of vascular surgery

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journal-article

Temporal regulation of venous extracellular matrix components during arteriovenous fistula maturation.

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The journal of vascular access

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journal-article

Arterial shear stress reduces eph-b4 expression in adult human veins.

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The Yale journal of biology and medicine

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journal-article

Vein graft adaptation and fistula maturation in the arterial environment.

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The Journal of surgical research

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journal-article

The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling.

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PloS one

Summary

journal-article

The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation.

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American journal of physiology. Heart and circulatory physiology

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journal-article

Technical aspects of the mouse aortocaval fistula.

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Journal of visualized experiments : JoVE

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journal-article

Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells.

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The Journal of surgical research

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journal-article

Reduced adult endothelial cell EphB4 function promotes venous remodeling.

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American journal of physiology. Cell physiology

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journal-article

Toward a mouse model of hind limb ischemia to test therapeutic angiogenesis.

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Journal of vascular surgery

Summary

journal-article

Pericardial patch angioplasty heals via an Ephrin-B2 and CD34 positive cell mediated mechanism.

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PloS one

Summary

journal-article

Therapeutic strategies to combat neointimal hyperplasia in vascular grafts.

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Expert review of cardiovascular therapy

Summary

journal-article

Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty.

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The journals of gerontology. Series A, Biological sciences and medical sciences

Summary

journal-article

Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo.

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Vascular pharmacology

Summary

journal-article

Age-related Notch-4 quiescence is associated with altered wall remodeling during vein graft adaptation.

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The Journal of surgical research

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journal-article

Eph-B4 prevents venous adaptive remodeling in the adult arterial environment.

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The Journal of experimental medicine

Summary

journal-article

Current usage and future directions for the bovine pericardial patch.

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Annals of vascular surgery

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journal-article

Mechanisms of vein graft adaptation to the arterial circulation: insights into the neointimal algorithm and management strategies.

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Circulation journal : official journal of the Japanese Circulation Society

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journal-article

Platelet-rich plasma: support for its use in wound healing.

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The Yale Journal of Biology and Medicine

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journal-article

Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamics.

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Annals of vascular surgery

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journal-article

Diminished omega-3 fatty acids are associated with carotid plaques from neurologically symptomatic patients: Implications for carotid interventions.

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Vascular pharmacology

Summary

journal-article

Patches for carotid artery endarterectomy: current materials and prospects.

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Journal of vascular surgery

Summary

journal-article

Venous and arterial identity: a role for caveolae?

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Vascular

Summary

journal-article

Limb ischemia after iliac ligation in aged mice stimulates angiogenesis without arteriogenesis.

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Journal of vascular surgery

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journal-article

Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway.

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Journal of cellular physiology

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journal-article

Control of blood vessel identity: from embryo to adult.

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Annals of Vascular Diseases

Summary

journal-article

Endothelial nitric oxide synthase stimulates aneurysm growth in aged mice.

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Journal of vascular research

Summary

journal-article

Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons.

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Journal of vascular surgery

Summary

journal-article

Venous identity is lost but arterial identity is not gained during vein graft adaptation.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

Evidence supporting changes in Nogo-B levels as a marker of neointimal expansion but not adaptive arterial remodeling.

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Vascular pharmacology

Summary

journal-article

Differential responsiveness of early- and late-passage endothelial cells to shear stress.

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American journal of surgery

Summary

journal-article

Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway.

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Journal of vascular surgery

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journal-article

Oscillatory shear stress increases smooth muscle cell proliferation and Akt phosphorylation.

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Journal of vascular surgery

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journal-article

Arterial wall shear stress: observations from the bench to the bedside.

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Vascular and endovascular surgery

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journal-article

Cells in focus: endothelial cell.

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The international journal of biochemistry & cell biology

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journal-article