Andrew O. Agbaje

About

Prof. Agbaje, MD, MPH, PhD, FESC, FAHA, FNYAM, Cert. Clinical Researcher (Harvard), is an award-winning physician and professor (associate) of clinical epidemiology and child health who currently investigates causal relationships of aerobic fitness, physical activity, sedentary behaviour, body composition, insulin resistance, dyslipidaemia, and metabolic syndrome with arterial, cardiac, liver, and kidney structure and function from childhood through young adulthood. Research group website https://urfit-child.com Prof Agbaje discovered childhood tobacco smoking as a cause of premature cardiac damage and identified that smoking prevalence increased 15 times between the age of 13 to 17 years. He also discovered arterial stiffness as a novel risk factor for paediatric obesity and insulin resistance, identified adolescence as the critical time to interrupt fat mass-insulin resistance pathologic cycle, and demonstrated light-intensity physical activity as a highly effective antidote for reversing excessive fat deposit induced by childhood sedentariness. Recently, he discovered waist-to-height ratio as a specific surrogate for fat mass but not muscle mass that could replace BMI in assessing childhood obesity. Subsequently, he was interviewed LIVE on BBC World News TV to discuss the novel findings. In December 2024, the American Heart Association selected Prof Agbaje’s study as one of the world’s most significant advances in cardiovascular research in 2024. In October 2023, two of Prof. Agbaje’s publications were placed in the Top 1% highly cited paper in the academic field of Clinical Medicine, while a third publication was placed in the Top 1% highly cited paper in the academic field of Biology & Biochemistry by Clarivate’s Web of Science. He has single/first authored original papers in highly prestigious journals such as JACC and Nature Communications. He was interviewed LIVE on BBC World Service Radio Newsday programme on 15th Dec 2023, BBC Radio Devon on 16th Jan 2024, and BBC World News LIVE TV programme on 14th March 2024. The University of Eastern Finland recorded a podcast interview of his findings as well as a video. His impactful research has received extensive press coverage, with over 2,500 media mentions between 2022 - 2024 in outlets such as CNN, Daily Mail, Mirror, BILD, Infobae, Yahoo Lifestyle, Yahoo Sport, US News & World report, DocCheck, MSN, WebMD, Medscape, The Conversation, Jerusalem Post, Helsingin Sanomat, etc, potentially reaching a global audience of more than 5.5 billion. The equivalent advertising value of these news articles is more than 30 million US dollars. The Endocrine Society in US recorded a podcast interview of his research and discussed his research in the prestigious Endocrine Magazine March 2024 edition. He gave a press conference at the ENDO 2024 congress in Boston, US. He was interviewed by the European Association for the Study of Obesity, a federation of 36 European countries’ professional associations and subsequently had a video interview at the European Congress on Obesity. He has received several scientific excellence awards including the prestigious EASO-Novo Nordisk Foundation for New Investigator Award in Childhood Obesity with a 300,000 Danish Kroner (€40,000 / 44,000 USD) prize. Other awards are the Endocrine Society Award for outstanding abstract, American Heart Association’s Elizabeth Barrett-Connor Research Award in Epidemiology and Prevention (once), Jeremiah and Rose Stamler Research Award (twice), and Paul Dudley White International Scholar Award (four times). He co-authored an American Heart Association Scientific Statement on Environmental Exposures and Pediatric Cardiology, published in Circulation. He had a video discussion of the Scientific Statement. He was an invited guest speaker to the largest mother and child center in Canada – CHU Sainte-Justine Mother and Child University Hospital Center, Canada in March 2023 to speak on the determinants of carotid intima-media thickness and arterial stiffness in pediatrics. He is an Honorary Research Fellow at the Children’s Health and Exercise Research Centre (CHERC), Department of Public Health and Sports Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. He is an Associate Editor in the Journal of Cachexia, Sarcopenia, and Muscle (JCSM), serves on the editorial board of Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). He is an elected Fellow of the European Society of Cardiology (FESC), an elected Fellow of the American Heart Association (FAHA), an elected Fellow of the New York Academy of Medicine (FNYAM). These titles of honour, symbol of excellence and lifetime achievement recognizes his significant contribution to cardiovascular field in Europe and America. He is an expert advisor to the World Health Organization and European Association for the Study of Obesity’s task force on preventing childhood obesity.

Work

University of Exeter
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Honorary Research Fellow

United Kingdom of Great Britain and Northern Ireland

University of Eastern Finland
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Project Researcher

Finland

Federal Medical Centre, Owerri
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Physician

Nigeria

Education

University of Eastern Finland
Finland

Doctoral program in clinical research

University of Portsmouth
United Kingdom of Great Britain and Northern Ireland

PhD by publication in Sport, Health and Exercise Science

Harvard University T H Chan School of Public Health
United States of America

Certificate in Principles and Practice of Clinical Research

University of Eastern Finland
Finland

Masters in Public Health/ Epidemiology (clinical epidemiology) (Distinction)

University of Benin School of Medicine
Nigeria

Bachelor of Medicine Bachelor of Surgery/ MD

Publications

Longitudinal association of peak oxygen uptake with vascular and cardiac structure and function in German pediatric athletes

Published by

American Journal of Physiology-Heart and Circulatory Physiology

Summary

journal-article

Persistent Hyperglycemia and Insulin Resistance With the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort

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Diabetes Care

Summary

journal-article

Novel Pediatric Waist-to-height Ratio Fat Mass Cutoff Predicts Liver Steatosis and Fibrosis Better than Body Mass Index: The NHANES

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Journal of the Endocrine Society

Summary

journal-article

Accelerometer-based sedentary time and physical activity with incident and progressive tobacco smoking in 2503 children: A 13-year mediation and temporal longitudinal study

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Behaviour Research and Therapy

Summary

journal-article

Incidental and Progressive Tobacco Smoking in Childhood and Subsequent Risk of Premature Cardiac Damage

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Journal of the American College of Cardiology

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journal-article

The Interactive Effects of Sedentary Time, Physical Activity, and Fat Mass on Insulin Resistance in the Young Population

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The Journal of Clinical Endocrinology & Metabolism

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journal-article

Lean Mass Longitudinally Confounds Sedentary Time and Physical Activity With Blood Pressure Progression in 2513 Children

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Journal of Cachexia, Sarcopenia and Muscle

Summary

journal-article

Waist-circumference-to-height-ratio had better longitudinal agreement with DEXA-measured fat mass than BMI in 7237 children

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Pediatric Research

Summary

journal-article

Accelerometer-based sedentary time and physical activity from childhood through young adulthood with progressive cardiac changes: a 13-year longitudinal study

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European Journal of Preventive Cardiology

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journal-article

DXA-based Fat Mass With Risk of Worsening Insulin Resistance in Adolescents: A 9-Year Temporal and Mediation Study

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The Journal of Clinical Endocrinology & Metabolism

Summary

journal-article

Author reply to correspondence from Hudda et al. on waist-circumference-to-height-ratio had better longitudinal agreement with DEXA-measured fat mass than BMI in 7237 children

Published by

Pediatric Research

Summary

journal-article

Associations of Sedentary Time and Physical Activity From Childhood With Lipids: A 13-Year Mediation and Temporal Study

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The Journal of Clinical Endocrinology & Metabolism

Summary

journal-article

Accelerometer‐based sedentary time, light physical activity, and moderate‐to‐vigorous physical activity from childhood with arterial stiffness and carotid IMT progression: A 13‐year longitudinal study of 1339 children

Published by

Acta Physiologica

Summary

journal-article

Mediating effect of fat mass, lean mass, blood pressure and insulin resistance on the associations of accelerometer-based sedentary time and physical activity with arterial stiffness, carotid IMT and carotid elasticity in 1574 adolescents

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Journal of Human Hypertension

Summary

journal-article

Increasing lipids with risk of worsening cardiac damage in 1595 adolescents: A 7-year longitudinal and mediation study

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Atherosclerosis

Summary

journal-article

Effects of accelerometer-based sedentary time and physical activity on DEXA-measured fat mass in 6059 children

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Nature Communications

Summary

journal-article

Longitudinal Mediating Effect of Fat Mass and Lipids on Sedentary Time, Light PA, and MVPA with Inflammation in Youth

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The Journal of Clinical Endocrinology & Metabolism

Summary

journal-article

A 7-year longitudinal association of total cholesterol with premature structural and functional cardiac damage progression in youth: the ALSPAC birth cohort study

Published by

European Heart Journal

Summary

journal-article

An average of 60mins/day of moderate to vigorous physical activity from childhood through young adulthood was associated with worsening cardiac structural damage in youth: A 13-year longitudinal study

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European Heart Journal

Summary

journal-article

Cumulative accelerometer-based light physical activity from childhood through young adulthood progressively decreases left ventricular mass in British youth: a 13-year longitudinal study

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European Heart Journal

Summary

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Cumulative accelerometer-based light physical activity from childhood through young adulthood with arterial stiffness and carotid intima-media thickness progression: a 13-year longitudinal study

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European Heart Journal

Summary

journal-article

Cumulative accelerometer-based sedentary time from childhood through young adulthood with increased arterial stiffness and carotid intima-media thickness in youth: a 13-year longitudinal study

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European Heart Journal

Summary

journal-article

Cumulative accelerometer-based sedentary time from childhood through young adulthood with progressive left ventricular remodelling in British youth: a 13-year longitudinal study

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European Heart Journal

Summary

journal-article

Increased triglyceride independently associates with premature structural and functional cardiac damage progression in asymptomatic adolescents: a 7-year longitudinal study

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European Heart Journal

Summary

journal-article

Prospective associations of non-HDL cholesterol with premature structural and functional cardiac damage progression in British youth: the ALSPAC study

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European Heart Journal

Summary

journal-article

Prospective associations of non-HDL cholesterol with premature structural and functional cardiac damage progression in British youth: the ALSPAC study

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European Heart Journal

Summary

journal-article

Arterial stiffness but not carotid intima-media thickness progression precedes premature structural and functional cardiac damage in youth: A 7-year temporal and mediation longitudinal study

Published by

Atherosclerosis

Summary

journal-article

Associations of accelerometer‐based sedentary time, light physical activity and moderate‐to‐vigorous physical activity with resting cardiac structure and function in adolescents according to sex, fat mass, lean mass, BMI, and hypertensive status

Published by

Scandinavian Journal of Medicine & Science in Sports

Summary

journal-article

Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study

Published by

American Journal of Physiology-Heart and Circulatory Physiology

Summary

journal-article

Does arterial stiffness mediate or suppress the associations of blood pressure with cardiac structure and function in adolescents?

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American Journal of Physiology-Heart and Circulatory Physiology

Summary

journal-article

Elevated Blood Pressure and Worsening Cardiac Damage During Adolescence

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The Journal of Pediatrics

Summary

journal-article

Longitudinal left ventricular mass indexing for DEXA-measured lean mass and fat mass: novel normative reference centiles in postpubertal adolescents and young adults

Published by

American Journal of Physiology-Heart and Circulatory Physiology

Summary

journal-article

Cardiorespiratory fitness in adolescence: a telescope into future cardiovascular health

Published by

European Journal of Preventive Cardiology

Summary

journal-article

Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study

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American Journal of Physiology-Endocrinology and Metabolism

Summary

journal-article

Temporal longitudinal associations of carotid-femoral pulse wave velocity and carotid intima-media thickness with resting heart rate and inflammation in youth

Published by

Journal of Applied Physiology

Summary

journal-article

Cumulative dyslipidemia with arterial stiffness and carotid IMT progression in asymptomatic adolescents: A simulated intervention longitudinal study using temporal inverse allocation model

Published by

Atherosclerosis

Summary

journal-article

To prevent hypertension in Africans: do we need to eat more vegetables?

Published by

European Journal of Preventive Cardiology

Summary

journal-article

Cumulative muscle mass and blood pressure but not fat mass drives arterial stiffness and carotid intima-media thickness progression in the young population and is unrelated to vascular organ damage

Published by

Hypertension Research

Summary

journal-article

Cumulative dyslipidaemia from mid-adolescence through young adulthood with carotid intima-media thickness progression: a 9-year longitudinal study

Published by

European Heart Journal

Summary

journal-article

Cumulative hyperinsulinemia, hyperglycaemia, and insulin resistance from mid-adolescence through young adulthood with carotid intima-media thickness progression: a 9-year longitudinal study

Published by

European Heart Journal

Summary

journal-article

Does arterial stiffness progression temporally precede higher low-grade inflammation in adolescents? Causal longitudinal evidence using auto-regressive cross-lagged structural equation models

Published by

European Heart Journal

Summary

journal-article

Longitudinal associations of cumulative dyslipidaemia from mid-adolescence through young adulthood with arterial stiffness progression: the ALSPAC study

Published by

European Heart Journal

Summary

journal-article

Simulated intervention and optimal timing for attenuating dyslipidaemia-related atherosclerotic progression in the young: a temporal inverse allocation analysis of the ALSPAC cohort

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European Heart Journal

Summary

journal-article

Temporal causal longitudinal associations of high-sensitivity C-reactive protein with carotid intima-media thickness progression in adolescents: the ALSPAC birth cohort study

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European Heart Journal

Summary

journal-article

Arterial stiffness precedes hypertension and metabolic risks in youth: a review

Published by

Journal of Hypertension

Summary

journal-article

Mediating role of body composition and insulin resistance on the association of arterial stiffness with blood pressure among adolescents: The ALSPAC study

Published by

Frontiers in Cardiovascular Medicine

Summary

journal-article

Adolescence arterial stiffness precedes elevated blood pressure in young adulthood: The ALSPAC birth cohort

Published by

Metabolism

Summary

journal-article

Adolescence arterial stiffness precedes insulin resistance in young adulthood: A 7-year temporal longitudinal findings using cross-lagged structural equation model

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Metabolism

Summary

journal-article

Effect of Arterial Stiffness and Carotid Intima-Media Thickness Progression on the Risk of Dysglycemia, Insulin Resistance, and Dyslipidemia: a Temporal Causal Longitudinal Study

Published by

Hypertension

Summary

journal-article

Fat mass paradox and carotid intima-media thickness progression: A longitudinal study from childhood through young adulthood

Published by

Metabolism

Summary

journal-article

Longitudinal and bi-directional associations of arterial stiffness with general and central fat mass from adolescence through young adulthood: The ALSPAC Study

Published by

Metabolism

Summary

journal-article

Effects of Arterial Stiffness and Carotid Intima-Media Thickness Progression on the Risk of Overweight/Obesity and Elevated Blood Pressure/Hypertension: a Cross-Lagged Cohort Study

Published by

Hypertension

Summary

journal-article

Arterial stiffness in adolescence predicts elevated blood pressure in young adulthood: the ALSPAC study

Published by

European Heart Journal

Summary

journal-article

Associations of endothelial function, arterial elasticity, and arterial stiffness with adiponectin and skeletal muscle mass

Published by

International Journal of Epidemiology

Summary

journal-article

Cardiorespiratory Fitness, Fat Mass, and Cardiometabolic Health with Endothelial Function, Arterial Elasticity, and Stiffness

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Medicine & Science in Sports & Exercise

Summary

journal-article

Arterial stiffness and carotid intima-media thickness in relation to cardiometabolic health in adolescence: The ALSPAC study

Published by

Atherosclerosis

Summary

journal-article

Association of carotid-femoral pulse wave velocity and carotid intima-media thickness with cardiometabolic risks among young adults: The Alspac study

Published by

Atherosclerosis

Summary

journal-article

Associations Of Endothelial Function, Arterial Elasticity, And Arterial Stiffness With Cardiorespiratory Fitness And Fat Mass

Published by

Medicine & Science in Sports & Exercise

Summary

journal-article

A 15-year Cumulative High Exposure to Lean Mass and Blood Pressure but not Fat Mass predicts the 7-year change in Carotid-Femoral Pulse Wave Velocity and Carotid Intima-Media Thickness: The ALSPAC study

Published by

Circulation

Summary

journal-article

LONGITUDINAL ASSOCIATIONS OF FAT MASS, LEAN MASS, BODY MASS INDEX AND BLOOD PRESSURE FROM CHILDHOOD THROUGH YOUNG ADULTHOOD WITH CAROTID-FEMORAL PULSE WAVE VELOCITY AND CAROTID INTIMA-MEDIA THICKNESS AT AGE 24.5 YEARS

Published by

Journal of the American College of Cardiology

Summary

journal-article

Adiponectin and lean mass in relation to endothelial function, arterial elasticity and arterial stiffness in 9-11-year-old-the ALSPAC study

Published by

Pediatric Diabetes

Summary

journal-article

Association of Fat Mass, Lean Mass, Body Mass Index, and Blood Pressure with Carotid-Femoral Pulse Wave Velocity and Carotid Intima-Media Thickness in Young Adults: The ALSPAC study

Published by

Metabolism Clinical and Experimental

Summary

journal-article

Mediating role of cardiorespiratory fitness on the association of cardiometabolic health with endothelial function, arterial elasticity and arterial stiffness in 9-11-year olds: The ALSPAC study

Published by

Atherosclerosis

Summary

journal-article

Effects of a 2-Year Lifestyle Intervention on Cardiorespiratory Fitness in 6-8- Year-Old Children: The PANIC Study

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Pediatric Exercise Science

Summary

conference-abstract

Associations of Cardiorespiratory Fitness and Adiposity With Arterial Stiffness and Arterial Dilatation Capacity in Response to a Bout of Exercise in Children

Published by

Pediatric Exercise Science

Summary

journal-article

Peak oxygen uptake cut‐points to identify children at increased cardiometabolic risk – The PANIC Study

Published by

Scandinavian Journal of Medicine & Science in Sports

Summary

journal-article

Associations of cardiorespiratory fitness and adiposity with arterial stiffness and arterial dilation capacity in response to exercise in children

Published by

Pediatric Exercise Science

Summary

conference-abstract