carsten uhd nielsen

Formulation Approaches for COVID-19 Vaccines

Nanotherapeutics for Infectious Diseases

Jan 2025

book-chapter

Fragment-Based Screening Identifies Novel Non-Amino Acid Inhibitors of the Sodium-Coupled Neutral Amino Acid Transporter SNAT2

Pharmaceutical Research

Jan 2025

journal-article

Fragment-Based Screening Identifies Novel Non-Amino Acid Inhibitors of the Sodium-Coupled Neutral Amino Acid Transporter SNAT2

Pharmaceutical Research

Jan 2025

journal-article

Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins

Journal of Medicinal Chemistry

Jan 2025

journal-article

The oral bioavailability of a pleuromutilin antibiotic candidate is increased after co-administration with the CYP3A4 inhibitor ritonavir and the P-gp inhibitor zosuquidar formulated as amorphous solid dispersions

International Journal of Pharmaceutics

Jan 2025

journal-article

Screening of a fragment-based library uncovers novel scaffolds for inhibitors of the sodium-coupled neutral amino acid transporter SNAT2

13th Uppsala University Symposium, 23/01/2025

Jan 2025

conference-poster

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors

Pharmaceutics

Jan 2025

journal-article

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors

Pharmaceutics

Jan 2025

journal-article

Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

Pharmaceutics

Jan 2024

journal-article

The infectious capacity of Enterococcus faecalis, Staphylococcus aureus, and Staphylococcus saprophyticus in a porcine model of urinary tract infection

APMIS

Jan 2024

journal-article

Structure-activity relationship of amino acid analogs to probe the binding pocket of sodium-coupled neutral amino acid transporter SNAT2

Amino Acids

Jan 2024

journal-article

Digestion of surfactants does not affect their ability to inhibit P-gp-mediated transport in vitro

International Journal of Pharmaceutics

Jan 2024

journal-article

Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel bioavailability in rats

International Journal of Pharmaceutics

Jan 2024

journal-article

Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate

Journal of Medicinal Chemistry

Jan 2024

journal-article

Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

Pharmaceutics

Jan 2024

journal-article

Investigations of potential non-amino acid SNAT2 inhibitors.

Frontiers in Pharmacology

Jan 2024

journal-article

Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells

Molecular and Cellular Biochemistry

Jan 2023

journal-article

Structure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains

Scientific Reports

Jan 2023

journal-article

Probing the Substrate Binding Site of SNAT2 With Amino Acid Analogues: A Structure-Activity Relationship Study

RESOLUTE Conference, Wien, Austria, 27/09/2023

Jan 2023

conference-poster

Increased bioavailability of a P-gp substrate

International Journal of Pharmaceutics

Jan 2023

journal-article

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Pharmaceutics

Jan 2023

journal-article

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Pharmaceutics

Jan 2023

journal-article

Recent Advances in Photothermal Therapies Against Cancer and the Role of Membrane Transporter Modulators on the Efficacy of This Approach

Technology in Cancer Research and Treatment

Jan 2023

journal-article

Molecular Networks and Macromolecular Molar Mass Distributions for Preliminary Characterization of Danish Craft Beers

Beverages

Jan 2022

journal-article

In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir

Journal of Drug Delivery Science and Technology

Jan 2022

journal-article

SNAT2 is responsible for hyperosmotic induced sarcosine and glycine uptake in human prostate PC-3 cells

Pflügers Archiv - European Journal of Physiology

Jan 2022

journal-article

P-glycoprotein-mediated transport in a mucus-supplemented Caco-2 cell model in the presence of different surfactants

International Journal of Pharmaceutics

Jan 2022

journal-article

Mechanism behind Polysorbates’ Inhibitory Effect on P-Glycoprotein

Molecular Pharmaceutics

Jan 2022

journal-article

Mechanism behind polysorbates' inhibitory effect on P-glycoprotein

Molecular Pharmaceutics

Jan 2022

journal-article

Molecular Networks and Macromolecular Molar Mass Distributions for Preliminary Characterization of Danish Craft Beers

Beverages

Jan 2022

journal-article

Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition

International Journal of Pharmaceutics: X

Jan 2021

journal-article

Corrigendum to 'Is Oral Absorption of Vigabatrin Carrier-mediated?' [European Journal of Pharmaceutical Sciences 69 (2015) 10-18]

European Journal of Pharmaceutical Sciences

Jan 2021

other

Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films

European Journal of Pharmaceutical Sciences

Jan 2021

journal-article

Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films

European Journal of Pharmaceutical Sciences

Jan 2021

journal-article

Inhibitory effects of 17-α-ethinyl-estradiol and 17-β-estradiol on transport via the intestinal proton-coupled amino acid transporter (PAT1) investigated In vitro and in vivo

Journal of Pharmaceutical Sciences

Jan 2021

journal-article

BeerMIMS

European Journal of Mass Spectrometry

Jan 2021

journal-article

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties

Pharmaceutics

Jan 2020

journal-article

Evaluation of P-glycoprotein efflux activity and cellular toxicity in MDCKII MDR1 cells in a one-pot assay

Nordic POP Annual meeting 2020 , Copenhagen , Denmark, 07/01/2020

Jan 2020

conference-poster

Zosuquidar alters etoposide permeability across Caco-2 cell monolayers by P-glycoprotein inhibition in a concentration-dependent manner

Nordic POP Annual meeting 2020 , Copenhagen , Denmark, 07/01/2020

Jan 2020

conference-poster

Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA

Journal of Medicinal Chemistry

Jan 2020

journal-article

Microenvironmental pH modifying films for buccal delivery of saquinavir

International Journal of Pharmaceutics

Jan 2020

journal-article

High-dose etoposide formulations do not saturate intestinal P-glycoprotein

International Journal of Pharmaceutics

Jan 2020

journal-article

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Pharmaceutics

Jan 2020

journal-article

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Pharmaceutics

Jan 2020

journal-article

Etoposide transport in MDCKII-MRP2 cells is unaffected by P-gp expression and commonly used pharmaceutical excipients

Nordic POP 1st Annual Meeting, Oslo, Norway, 14/01/2019

Jan 2019

conference-output

Transcriptome analysis identifies activated signaling pathways and regulated ABC transporters and solute carriers after hyperosmotic stress in renal MDCK I cells

Genomics

Jan 2019

journal-article

Transcriptome analysis identifies activated signaling pathways and regulated ABC transporters and solute carriers after hyperosmotic stress in renal MDCK I cells

Genomics

Jan 2019

journal-article

The permeation of acamprosate is predominantly caused by paracellular diffusion across Caco-2 cell monolayers

Molecular Pharmaceutics

Jan 2019

journal-article

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Molecular Pharmaceutics

Jan 2019

journal-article

Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport

International Journal of Pharmaceutics

Jan 2019

journal-article

Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport

International Journal of Pharmaceutics

Jan 2019

journal-article

Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC)

International Journal of Pharmaceutics

Jan 2019

journal-article

MRP2-mediated transport of etoposide in MDCKII MRP2 cells is unaffected by commonly used non-ionic surfactants

International Journal of Pharmaceutics

Jan 2019

journal-article

Nfat5 is involved in the hyperosmotic regulation of Tmem184b: a putative modulator of ibuprofen transport in renal MDCK I cells

FEBS Open Bio

Jan 2019

journal-article

Nfat5 is involved in the hyperosmotic regulation of Tmem184b

FEBS Open Bio

Jan 2019

journal-article

Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1

Nordic POP 1st Annual Meeting, Oslo, Norway, 14/01/2019

Jan 2019

conference-output

Montmorillonite-surfactant hybrid particles for modulation of intestinal P-glycoprotein mediated transport

Nordic POP 1st Annual Meeting, Oslo, Norway, 14/01/2019

Jan 2019

conference-poster

Amino acid transport in prostate PC-3 cells

Nordic POP 1st Annual Meeting, Oslo, Norway, 14/01/2019

Jan 2019

conference-output

Acamprosate permeability across Caco-2 cell monolayer is predominantly paracellular

Northern Pharma Network Meeting & POP Kick off-Meeting Conference 2018, Odense, Odense, Denmark, 29/01/2018

Jan 2018

conference-output

Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells

International Journal of Pharmaceutics

Jan 2018

journal-article

How is sarcosine transported into prostate PC‐3 cells?

The Danish Chemical Society Annual Meeting 2018

, Odense, Denmark, 23/08/2018

Jan 2018

conference-poster

Hyperosmolality regulates mRNA expression of membrane transporters in renal MDCK I cells

Northern Pharma Network Meeting & POP Kick off-Meeting Conference, Odense, Denmark, 29/01/2018

Jan 2018

conference-poster

Nonionic surfactants alter calcein-AM efflux in MDCKII MDR1 cells

Northern Pharma Network Meeting & POP Kick off-Meeting Conference 2018, Odense, Odense, Denmark, 29/01/2018

Jan 2018

conference-poster

Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats

International Journal of Pharmaceutics

Jan 2018

journal-article

Glutamate Transporters in the Blood-Brain Barrier

Glial Amino Acid Transporters

Jan 2017

book-chapter

Transport and metabolism of l‑glutamate in brain capillary endothelial cells and astrocytes

Fluids and Barriers of the CNS

Jan 2017

conference-abstract

Oral and intravenous pharmacokinetics of taurine in sprague-dawley rats: the influence of dose and the possible involvement of the proton-coupled amino acid transporter, PAT1, in oral taurine absorption

Physiological Reports

Jan 2017

journal-article

Oral and intravenous pharmacokinetics of taurine in sprague-dawley rats

Physiological Reports

Jan 2017

journal-article

SGLT1-Mediated Transport in Caco-2 Cells Is Highly Dependent on Cell Bank Origin.

Journal of pharmaceutical sciences

Jan 2017

journal-article

SGLT1-mediated transport in Caco-2 cells is highly dependent on cell bank origin

Journal of Pharmaceutical Sciences

Jan 2017

journal-article

Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Jan 2017

journal-article

Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model

Journal of Cerebral Blood Flow & Metabolism

Jan 2017

journal-article

Glutamate Transporters in the Blood-Brain Barrier.

Advances in neurobiology

Jan 2017

journal-article

A Transporter of Ibuprofen is Upregulated in MDCK I cells under Hyperosmotic Culture Conditions

Molecular Pharmaceutics

Jan 2016

journal-article

Application of Cell Culture and Tissue Models for Assessing Drug Transport

Analytical Techniques in the Pharmaceutical Sciences

Jan 2016

book-chapter

Hyperosmolality regulates transporters in renal MDCK I cells

The Annual Meeting of the Danish Chemical Society, Odense, Denmark, 09/06/2016

Jan 2016

conference-poster

Ibuprofen transport in renal cell cultures: Characterization of an ibuprofen transporter upregulated by hyperosmolarity

MedChemComm

Jan 2016

journal-article

Ibuprofen transport in renal cell cultures: characterization of an ibuprofen transporter upregulated by hyperosmolarity

MedChemComm

Jan 2016

journal-article

Ibuprofen transport in renal cell cultures

MedChemComm

Jan 2016

journal-article

PAT1 contributes to the absorption of taurine in vivo

The Annual Meeting of the Danish Chemical Society, Odense, Denmark, 09/06/2016

Jan 2016

conference-poster

Tween 20 increases intestinal transport of doxorubicin in vitro but not in vivo

International Journal of Pharmaceutics

Jan 2016

journal-article

Tween 20 increase absorptive digoxin transport in MDCKII-MDR1 cells

The Annual Meeting of the Danish Chemical Society, Odense, Denmark, 09/06/2016

Jan 2016

conference-poster

Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in mdr1a(-/-) Sprague Dawley rats

International Journal of Pharmaceutics

Jan 2016

journal-article

Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in mdr1a(-/-) Sprague Dawley rats

International Journal of Pharmaceutics

Jan 2016

journal-article

Tween 20 increases intestinal transport of doxorubicin in vitro but not in vivo

International Journal of Pharmaceutics

Jan 2016

journal-article

Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells

European Journal of Pharmaceutical Sciences

Jan 2016

journal-article

Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells

European Journal of Pharmaceutical Sciences

Jan 2016

journal-article

Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated caco-2, LLC-PK1 and rat renal SKPT cells

European Journal of Pharmaceutical Sciences

Jan 2016

journal-article

17-β-estradiol and ethinyl-estradiol inhibit PAT1-mediated taurine transport in Caco-2 cells, but doesn’t alter the pharmacokinetic profile in vivo

The Annual Meeting of the Danish Chemical Society, Odense, Denmark, 09/06/2016

Jan 2016

conference-poster

A transporter of ibuprofen is upregulated in MDCK i cells under hyperosmotic culture conditions

Molecular Pharmaceutics

Jan 2016

journal-article

Is oral absorption of vigabatrin carrier-mediated?

European Journal of Pharmaceutical Sciences

Jan 2015

journal-article

Estradiol and ethinyl-estradiol decrease proline uptake and transport in intestinal Caco-2 cells

Amino Acids

Jan 2015

conference-abstract

Is oral absorption of vigabatrin carrier-mediated?

European Journal of Pharmaceutical Sciences

Jan 2015

journal-article

The anti-epileptic drug substance vigabatrin inhibits transport via the taurine transporter (TauT, SLC6A6) in SKPT cells

Amino Acids

Jan 2015

conference-abstract

In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption

Pharmaceutical Research

Jan 2015

journal-article

IN VITRO MEMBRANE PERMEATION STUDIES AND IN VIVO ANTINOCICEPTION OF GLYCOSYLATED Dmt1-DALDA ANALOGUES

33rd European Peptide Society Symposium, Sofia, Bulgaria, 31/08/2014

Jan 2014

conference-presentation

Efflux transporter expression in a tight in vitro model of the blood brain barrier

Cold Spring Harbor Conference, Cold Spring Harbor, United States, 10/12/2014

Jan 2014

conference-output

Transport pathways mediating blood-to-brain L-glutamate efflux

Cold Spring Harbor Conference, Cold Spring Harbor, United States, 10/12/2014

Jan 2014

conference-output

Glutamate Efflux at the Blood-Brain Barrier

Archives of Medical Research

Jan 2014

journal-article

The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models.

Jan 2014

journal-article

The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models

International Journal of Pharmaceutics

Jan 2014

journal-article

The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models

International Journal of Pharmaceutics

Jan 2014

journal-article

A Tight Blood-Brain Barrier Model Displays Brain-to-Blood Efflux of Substrates for the ABC-Transporters, P-gp, BCRP and MRP-1

Signal Transduction in The Blood-Brain Barriers, Potsdam, Germany, 13/09/2012

Jan 2014

conference-output

An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1

AAPS Journal

Jan 2014

journal-article

An Electrically Tight In Vitro Blood-Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

The AAPS Journal

Jan 2014

journal-article

In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption: Effect of Dose and Inhibitors on Carrier-Mediated Transport.

Jan 2014

journal-article

Pharmacokinetic aspects of the anti-epileptic drug substance vigabatrin: Focus on transporter interactions

Therapeutic Delivery

Jan 2014

journal-article

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

European Journal of Pharmaceutical Sciences

Jan 2014

journal-article

IN VITRO MEMBRANE PERMEATION STUDIES AND IN VIVO ANTINOCICEPTION OF GLYCOSYLATED Dmt1-DALDA ANALOGUES

33rd European Peptide Society Symposium, Sofia, Bulgaria, 31/08/2014

Jan 2014

conference-output

Intestinal absorption of the antiepileptic drug substance vigabatrin in Gottingen mini-pigs is unaffected by co-administration of amino acids.

Jan 2014

journal-article

Intestinal absorption of the antiepileptic drug substance vigabatrin in Göttingen mini-pigs is unaffected by co-administration of amino acids

International Journal of Pharmaceutics

Jan 2014

journal-article

Intestinal absorption of the antiepileptic drug substance vigabatrin in Göttingen mini-pigs is unaffected by co-administration of amino acids

International Journal of Pharmaceutics

Jan 2014

journal-article

Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1

Meet the Experts: Transporter Conference- 2014, Budapest, Hungary, 02/04/2014

Jan 2014

conference-output

In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues.

Jan 2014

journal-article

In vitro membrane permeation studies and in vivo antinociception of glycosylated Dmt1-DALDA analogues

ACS Medicinal Chemistry Letters

Jan 2014

journal-article

In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt1-DALDA Analogues

ACS Medicinal Chemistry Letters

Jan 2014

journal-article

Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo

Pharmacology Research & Perspectives

Jan 2014

journal-article

PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats.

Jan 2014

journal-article

PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats

American Journal of Physiology - Endocrinology and Metabolism

Jan 2014

journal-article

PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats

American Journal of Physiology: Endocrinology and Metabolism

Jan 2014

journal-article

An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.

Jan 2014

journal-article

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers.

Jan 2014

journal-article

Pharmacokinetic aspects of the anti-epileptic drug substance vigabatrin

Therapeutic Delivery

Jan 2014

journal-article

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

European Journal of Pharmaceutical Sciences

Jan 2014

journal-article

Vigabatrin absorption is mediated via the proton-coupled amino acid transporter PAT1 – in vitro and in vivo

Jan 2013

conference-poster

In vivo and in vitro evaluations of intestinal gabapentin absorption: Effect of dose and inhibitors on carrier-mediated transport

Pharmaceutical Research

Jan 2013

journal-article

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro.

Jan 2013

journal-article

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

British Journal of Pharmacology

Jan 2013

journal-article

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

British Journal of Pharmacology

Jan 2013

journal-article

Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent.

Jan 2013

journal-article

Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

Journal of Pharmacy and Pharmacology

Jan 2013

journal-article

Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

Journal of Pharmacy and Pharmacology

Jan 2013

journal-article

PAT1-inhibitors reduce oral absorption rate of vigabatrin in rats

PAGE 2013, Glasgow, United Kingdom, 11/06/2013

Jan 2013

conference-poster

Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

45 Sandbjerg Meeting on Membrane Transport, Sønderborg, Denmark, 27/05/2013

Jan 2013

conference-output

Cellemodel af blodhjernebarrieren kan mindske brugen af forsøgsdyr

Lægemiddelforskning

Jan 2013

journal-article

Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)

Journal of Drug Delivery Science and Technology

Jan 2013

journal-article

Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)

Journal of Drug Delivery Science and Technology

Jan 2013

journal-article

Membrane Transporters in ADME

Transporters in Drug Development

Jan 2013

book-chapter

Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

Journal of Drug Delivery Science and Technology

Jan 2013

journal-article

Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

Journal of Drug Delivery Science and Technology

Jan 2013

journal-article

In-vitro models of the blood brain barrier

44th Sandbjerg Meeting on Membrane Transport, Sandbjerg, Denmark, 14/05/2012

Jan 2012

conference-output

Kostens sammensætning kan påvirke optagelsen af lægemiddelstoffer

Lægemiddelforskning

Jan 2012

journal-article

The proton-coupled amino acid transporter hPAT1 is the main transporter involved in vigabatrin uptake in intestinal Caco-2 cells

Jan 2012

conference-poster

Function and expression of the proton-coupled amino acid transporter PAT1 along the rat gastrointestinal tract: implications for intestinal absorption of gaboxadol.

Jan 2012

journal-article

Function and expression of the proton-coupled amino acid transporter PAT1 along the rat gastrointestinal tract: Implications for intestinal absorption of gaboxadol

British Journal of Pharmacology

Jan 2012

journal-article

Function and expression of the proton-coupled amino acid transporter Slc36a1 along the rat gastrointestinal tract

British Journal of Pharmacology

Jan 2012

journal-article

In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

Signal Transduction in The Blood-Brain Barriers, Potsdam, Germany, 13/09/2012

Jan 2012

conference-output

Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides.

Jan 2012

journal-article

Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by gly-Xaa dipeptides

Molecular Pharmaceutics

Jan 2012

journal-article

Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides

Molecular Pharmaceutics

Jan 2012

journal-article

Carrier-mediated γ-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers.

Jan 2012

journal-article

Carrier-mediated γ-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2012

journal-article

Carrier-mediated ¿-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2012

journal-article

In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate.

Jan 2012

journal-article

In vitro evidence for the brain glutamate efflux hypothesis: Brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

GLIA

Jan 2012

journal-article

In vitro evidence for the brain glutamate efflux hypothesis

Glia

Jan 2012

journal-article

Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats.

Jan 2012

journal-article

Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats

Pharmaceutical Research

Jan 2012

journal-article

Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PATI, Slc36ai) in rats

Pharmaceutical Research

Jan 2012

journal-article

Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

44'th Sandbjerg Meeting on Membrane Transport, Sønderborg, Denmark, 14/05/2012

Jan 2012

conference-output

Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1.

Jan 2012

journal-article

Identification and characterization of a novel nontranslated sequence variant of the human intestinal Di-/Tripeptide transporter, hPEPT1

International Journal of Peptides

Jan 2012

journal-article

Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1

International Journal of Peptides

Jan 2012

journal-article

Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1(hPAT1)-A modelling approach to determine IC50 values of the three ionic species of gaboxadol

European Journal of Pharmaceutical Sciences

Jan 2011

journal-article

Transport af lægemiddelstoffer gennem vævsbarrier

Bioteknologi - en temabog

Jan 2011

book-chapter

The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1.

Jan 2011

journal-article

The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1

Bioorganic and Medicinal Chemistry Letters

Jan 2011

journal-article

The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1

Bioorganic & Medicinal Chemistry Letters

Jan 2011

journal-article

Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances.

Jan 2011

journal-article

Calu-3 cells grown under AIC and LCC conditions: Implications for dipeptide uptake and transepithelial transport of substances

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2011

journal-article

Calu-3 cells grown under AIC and LCC conditions

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2011

journal-article

Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs.

Jan 2011

journal-article

Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: Evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2011

journal-article

Affinity and translocation relationships via hPEPT1 of H-Xaa-Ser-OH dipeptides

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2011

journal-article

Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)--A modelling approach to determine IC(50) values of the three ionic species of gaboxadol.

Jan 2011

journal-article

Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1) - A modelling approach to determine IC50 values of the three ionic species of gaboxadol

European Journal of Pharmaceutical Sciences

Jan 2011

journal-article

Stoftransport af lægemiddelstoffer gennem vævsbarrierer.

Bioteknologi – en temabog.

Jan 2011

book-chapter

A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)

AAPS Journal

Jan 2010

journal-article

Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen.

Jan 2010

journal-article

Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): Possible interactions between hPEPT1 substrates and ibuprofen

British Journal of Pharmacology

Jan 2010

journal-article

Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

British Journal of Pharmacology

Jan 2010

journal-article

Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth.

Jan 2010

journal-article

Paracellular tightness and claudin-5 expression is increased in the bcec/astrocyte blood-brain barrier model by increasing media buffer capacity during growth

AAPS Journal

Jan 2010

journal-article

Paracellular tightness and claudin-5 expression is increased in the BCEC/Astrocyte blood-brain barrier model by increasing media buffer capacity during growth

The AAPS Journal

Jan 2010

journal-article

The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics

British Journal of Pharmacology

Jan 2010

journal-article

The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics

British Journal of Pharmacology

Jan 2010

journal-article

A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1).

Jan 2010

journal-article

A Quantitative Structure–Activity Relationship for Translocation of Tripeptides via the Human Proton-Coupled Peptide Transporter, hPEPT1 (SLC15A1)

The AAPS Journal

Jan 2010

journal-article

Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1).

Jan 2010

journal-article

δ-Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)

British Journal of Pharmacology

Jan 2010

journal-article

d-Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)

British Journal of Pharmacology

Jan 2010

journal-article

Gly-Sar is a substrate for the human proton-coupled amino acid transporter, hPAT1 (SLC36A1)

Joint meeting of the Scandinavian and german physiological societies, Copenhagen, Denmark, 27/03/2010

Jan 2010

conference-output

Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

Joint meeting of the Scandinavian and german physiological societies, Copenhagen, Denmark, 27/03/2010

Jan 2010

conference-output

mRNA expression and transport function of the proton-coupled amino acid transporter , PAT1, along the rat intestine

Joint meeting of the Scandinavian and german physiological societies, Copenhagen, Denmark, 27/03/2010

Jan 2010

conference-output

5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.

Jan 2010

journal-article

5-Hydroxy-l-tryptophan alters gaboxadol pharmacokinetics in rats: Involvement of PAT1 and rOat1 in gaboxadol absorption and elimination

European Journal of Pharmaceutical Sciences

Jan 2010

journal-article

5-Hydroxy-L-tryptohan alters gaboxadol pharmacokinetics in rats

European Journal of Pharmaceutical Sciences

Jan 2010

journal-article

Absorptive transporters

Molecular Biopharmaceutics

Jan 2010

book-chapter

Acid/base properties, solubility and distribution of drug candidates

Molecular Biopharmaceutics

Jan 2010

book-chapter

Carrier-mediated transport kinetics

Molecular Biopharmaceutics

Jan 2010

book-chapter

Claudin-5 mRNA expression and transendothelial electrical resistance (TEER) correlate in the BCEC/astrocyte blood-brain barrier model

2010 AAPS Annual Meeting and Exposition, New Orleans, United States, 14/11/2010

Jan 2010

conference-output

Efflux transporters

Molecular Biopharmaceutics

Jan 2010

book-chapter

GABA transport across the basolateral membrane of intestinal cells

Joint Meeting of the Scandinavian and German Physiological Societies, København, Denmark, 27/03/2010

Jan 2010

conference-output

Gly-sar is a substrate for the human proton coupled amino acid trasporter 1, hPAT1 (SLC36A1)

Joint meeting of the Scandinavian and german physiological societies, Copenhagen, Denmark, 27/03/2010

Jan 2010

conference-poster

Hjernens forsvarsmur kortlagt og kopieret

Lægemiddelforskning

Jan 2010

journal-article

Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption, Copenhagen, Denmark, 27/03/2010

Jan 2010

conference-poster

In vitro models for investigating the function of proton-coupled amino acid transporter 1 (PAT1, SLC36A19)

2010 AAPS Annual Meeting and Exposition, New Orleans, United States, 14/11/2010

Jan 2010

conference-output

Introduction

Molecular biopharmaceutics

Jan 2010

book-chapter

Introduction

Molecular Biopharmaceutics

Jan 2010

book-chapter

Kinetics of decomposition in aqueous solution

Molecular Biopharmaceutics

Jan 2010

book-chapter

Mechanisms of decomposition of drug candidates

Molecular Biopharmaceutics

Jan 2010

book-chapter

Passive diffusion of drug substances

Molecular Biopharmaceutics

Jan 2010

book-chapter

Structure and function of absorption barriers

Molecular Biopharmaceutics

Jan 2010

book-chapter

The expression of Claudin-5 correlates with transendothelial electrical resistance (TEER) in BCEC/rat astrocyte blood-brain barrier models

Globalization of Pharmaceutics Education Network Meeting 2010, Chapel Hill, North Carolina, United States, 09/11/2010

Jan 2010

conference-output

Transportes in gastrointestinal tract

Drug bioavailability

Jan 2010

book-chapter

mRNA expression and transport function of the proton-coupled amino acid transporter, PAT1, along the rat intestine

Joint Meeting of the Scandinavian and German Physiological Societies, København, Denmark, 27/03/2010

Jan 2010

conference-output

The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics.

Jan 2010

journal-article

Gaboxadol bliver absorberet via en aminosyretransportør

Lægemiddelforskning

Jan 2009

journal-article

Discovery of ligands for the human intestinal Di-/Tripeptide transporter (hPEPT1) using a QSAR-assisted virtual screening strategy.

Jan 2009

journal-article

Discovery of ligands for the human intestinal Di-/tripeptide transporter (hPEPT1) using a QSAR-assisted virtual screening strategy

ChemMedChem

Jan 2009

journal-article

Discovery of ligands for the human intestinal di-/tripeptide transporter (hPEPT1) using af QSAR-assisted virtual screening strategy

ChemMedChem

Jan 2009

journal-article

Characterization of in-vitro blood-brain barrier models

BioMedical Transporters 2009, Bern, Switzerland, 09/08/2009

Jan 2009

conference-output

Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan.

Jan 2009

journal-article

Intestinal gaboxadol absorption via PAT1 (SLC36A1): Modified absorption in vivo following co-administration of L-tryptophan

British Journal of Pharmacology

Jan 2009

journal-article

Intestinal gaboxadol absorption via PAT1 (SLC36A1)

British Journal of Pharmacology

Jan 2009

journal-article

Transport of Gaboxadol via hPAT1 and rOAT1 in the absence and presence of 5-HTP

36th Annual Meeting & Exposition of the controlled release society - Innovation in discovery, diagnostics, and delivery, Copenhagen, Denmark, 18/07/2009

Jan 2009

conference-output

In vitro blood-brain barrier models

36th Annual Meeting & Exposition of the controlled release society - Innovation in discovery, diagnostics, and delivery, Copenhagen, Denmark, 18/07/2009

Jan 2009

conference-output

Transporters in the gastrointestinal tract

Drug Bioavailability:

Jan 2009

book-chapter

Modified absorption formulation of gaboxadol

Jan 2009

patent

Peptide transporters in drug delivery; The human peptide transporter 1 (hPEPT1) translocates differently charged peptides in an electrogenic manner, indicating a varying proton coupling ration

41th Sandbjerg Meeting om Membrane Transport, Sønderborg, Denmark, 11/05/2009

Jan 2009

conference-output

Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity.

Jan 2008

journal-article

Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells.

Jan 2008

journal-article

Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: Characterization of conditions for affinity and transport experiments in Caco-2 cells

European Journal of Pharmaceutical Sciences

Jan 2008

journal-article

Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1

European Journal of Pharmaceutical Sciences

Jan 2008

journal-article

Dipeptide derivatives of AZT: Synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity

ChemMedChem

Jan 2008

journal-article

Dipeptide derivatives of AZT

ChemMedChem

Jan 2008

journal-article

hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3.

Jan 2008

journal-article

hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3

Pflugers Archiv European Journal of Physiology

Jan 2008

journal-article

hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3

Pflügers Archiv - European Journal of Physiology

Jan 2008

journal-article

Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1.

Jan 2008

journal-article

Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1

European Journal of Pharmaceutical Sciences

Jan 2008

journal-article

Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1

European Journal of Pharmaceutical Sciences

Jan 2008

journal-article

Basolateral peptid etransport in the human intestinal cell line Caco-2 is proton-coupled

Globalization of Pharmaceutics Education Network Meeting 2008, Leuven, Belgium, 09/09/2008

Jan 2008

conference-output

Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1

ChemMedChem

Jan 2007

journal-article

Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1

ChemMedChem

Jan 2007

journal-article

Proton-coupled basolateral dipeptide transport in a human intestinal cell line, Caco-2

3rd Pharmaceutical Sciences World Congress, Amsterdam, Netherlands, 22/04/2007

Jan 2007

conference-output

The human proton-coupled amino acid transporter (hPAT1) is a transport system for GABA-like drugs

22007 Annual AAPS Meeting, San Diego, United States, 11/11/2007

Jan 2007

conference-output

Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1.

Jan 2007

journal-article

Transportpeptider

Lægemiddelforskning

Jan 2007

journal-article

Basolateral peptide transport in intestinal cells is pH dependent

39th Sandbjerg Meeting on Membrane Transport, Sandbjerg, Denmark, 16/05/2007

Jan 2007

conference-output

Molekylær biofarmaci - når medicinen skyder genvej!

Lægemiddelforskning

Jan 2007

journal-article

Optimization of a cell-based flourescent probe assay for measuring substrate translocation via the proton-coupled intestinal di/tri-peptide transporter hPEPT1

ULLA Summerschool 2007, Leiden, Netherlands, 29/06/2007

Jan 2007

conference-output

Peptide Transporters in Drug Delivery

Joint meeting of the German and the Danish Pharmacological Societies, Copenhagen, Denmark, 21/06/2007

Jan 2007

conference-output

In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

European Journal of Pharmaceutical Sciences

Jan 2006

journal-article

Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters.

Jan 2006

journal-article

Carbonic anhydrase imhibitors. Transepithelial transport of novel anticancer sulfonamide inhibitors of the cancer-associated isozyme CA IX is dependent on the p.gp efflux transporter

Bioorganic & Medicinal Chemistry Letters

Jan 2006

journal-article

Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1.

Jan 2006

journal-article

Genetic variants of the human dipeptide transporter PEPT1

The Journal of Pharmacology and Experimental Therapeutics

Jan 2006

journal-article

Genetic variants of the human dipeptide transporter PEPT1

Journal of Pharmacology and Experimental Therapeutics

Jan 2006

journal-article

Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1

Pharmaceutical Research

Jan 2006

journal-article

Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal Di-/tripeptide transporter hPEPT1

Pharmaceutical Research

Jan 2006

journal-article

Genetic variants of the human dipeptide transporter PEPT1.

Jan 2006

journal-article

In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1.

Jan 2006

journal-article

In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

European Journal of Pharmaceutical Sciences

Jan 2006

journal-article

Carbonic anhydrase inhibitors: Transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters

Bioorganic and Medicinal Chemistry

Jan 2006

journal-article

Carrier-mediated dipeptide transport in a human lung epithelial cell line, Calu-3

American Association of Pharmaceutical Scientists (AAPS) annual meeting and exhibition, San Antonio, United States, 12/11/2006

Jan 2006

conference-output

Insulin increases peptide transport capacity in the proximal tubule kidney cell line SKPT0193-Cl.2.

American Association of Pharmaceutical Scientists (AAPS) annual meeting and exhibition, San Antonio, United States, 12/11/2006

Jan 2006

conference-output

Proton dependent transport of amino acids in Caco-2 cells

Sandbjerg Meeting on Membrane Transport, Sandbjerg, Denmark, 31/05/2006

Jan 2006

conference-output

Delivery aspects of small peptides and substrates for peptide transporters.

Jan 2005

journal-article

Delivery aspects of small peptides and substrates for peptide transporters

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2005

journal-article

Delivery aspects of small peptides and substrates for peptide transporters

European Journal of Pharmaceutics and Biopharmaceutics

Jan 2005

journal-article

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs.

Jan 2005

journal-article

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: Implications for design of hPEPT1 targeted prodrugs

Bioorganic and Medicinal Chemistry

Jan 2005

journal-article

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter

Bioorganic & Medicinal Chemistry

Jan 2005

journal-article

Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media.

Jan 2005

journal-article

Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media

Molecular Pharmaceutics

Jan 2005

journal-article

Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media

Molecular Pharmaceutics

Jan 2005

journal-article

Forudsigelser med hjælp fra det virtuelle rum

Lægemiddelforskning

Jan 2005

journal-article

Recent advances in therapeutic applications of human peptide transporters

Expert Opinion on Therapeutic Patents

Jan 2005

journal-article

Recent advances in therapeutic applications of human transporters

Expert Opinion on Therapeutic Patents

Jan 2005

journal-article

The F28Y substitution in the human intestinal di/tri-peptide transporter hPEPT1, causes altered pH-dependency of Gly-Sar transport

3rd World Conference on Drug Absorption, Transport and Delivery, Barcelona, Spain, 18/04/2005

Jan 2005

conference-output

Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions.

Jan 2004

journal-article

Genetic variants of the human H+/dipeptide transporter PEPT2: Analysis of haplotype functions

Journal of Pharmacology and Experimental Therapeutics

Jan 2004

journal-article

Genetic variants of the human H+/dipeptide transporter PEPT2

The Journal of Pharmacology and Experimental Therapeutics

Jan 2004

journal-article

Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: design, synthesis, stability, and biological investigations.

Jan 2004

journal-article

Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: Design, synthesis, stability, and biological investigations

Journal of Medicinal Chemistry

Jan 2004

journal-article

Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1

Journal of Medicinal Chemistry

Jan 2004

journal-article

Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2.

Jan 2004

journal-article

Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 c1.2

American Journal of Physiology - Renal Physiology

Jan 2004

journal-article

Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2

American Journal of Physiology: Renal Physiology

Jan 2004

journal-article

Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations.

Jan 2004

journal-article

Phe-Gly Dipeptidomimetics Designed for the Di-/Tripeptide Transporters PEPT1 and PEPT2: Synthesis and Biological Investigations

Journal of Medicinal Chemistry

Jan 2004

journal-article

Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2

Journal of Medicinal Chemistry

Jan 2004

journal-article

In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model.

Jan 2004

journal-article

In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model

European Journal of Pharmaceutical Sciences

Jan 2004

journal-article

In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model

European Journal of Pharmaceutical Sciences

Jan 2004

journal-article

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption.

Jan 2004

journal-article

Intestinal solute carriers: An overview of trends and strategies for improving oral drug absorption

European Journal of Pharmaceutical Sciences

Jan 2004

journal-article

Intestinal solute carriers

European Journal of Pharmaceutical Sciences

Jan 2004

journal-article

Dipeptide ketomethylene isosteres as pro-moeities for drug transport via human intestinal di/tripeptide transport hPEPT1. Design, synthesis, stability and biological investigations

Journal of Medicinal Chemistry

Jan 2004

journal-article

Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions.

Jan 2003

journal-article

Erratum

Journal of Controlled Release

Jan 2003

journal-article

Di/tri-peptide transporters as drug delivery targets: Regulation of transport under physiological and patho-physiological conditions

Current Drug Targets

Jan 2003

journal-article

Di/tri-peptide transporters as drug delivery targets

Current Drug Targets

Jan 2003

journal-article

Epidermal growth factor and insulin short-term increase hPepT1-mediated glycylsarcosine uptake in Caco-2 cells.

Jan 2003

journal-article

Epidermal growth factor and insulin short-term increase hPepT1-mediated glycylsarcosine uptake in Caco-2 cells

Acta Physiologica Scandinavica

Jan 2003

journal-article

Epidermal growth factor and insulin short-term increase hPEPT1-mediated glycylsarcosine uptake in Caco-2 cells

Acta Physiologica Scandinavica

Jan 2003

journal-article

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism.

Jan 2003

journal-article

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism

Journal of Controlled Release

Jan 2003

journal-article

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1

Journal of Controlled Release

Jan 2003

journal-article

Erratum: Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism (Journal of Controlled Release (2003) 86 (279-292) PII: S0168365902004133)

Journal of Controlled Release

Jan 2003

journal-article

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Pharmaceutical Research

Jan 2002

journal-article

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Pharmaceutical Research

Jan 2002

journal-article

Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1.

Jan 2002

journal-article

Transport of peptidomimetic drugs by the intestinal di/tri-peptide transporter, PepT1

Pharmacology and Toxicology

Jan 2002

journal-article

Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1

Basic & Clinical Pharmacology & Toxicology

Jan 2002

journal-article

Human peptide transporters: Therapeutic applications

Expert Opinion on Therapeutic Patents

Jan 2002

journal-article

Human peptide transporters

Expert Opinion on Therapeutic Patents

Jan 2002

journal-article

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line.

Jan 2002

journal-article

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.

Jan 2001

journal-article

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

Journal of Controlled Release

Jan 2001

journal-article

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

Journal of Controlled Release

Jan 2001

journal-article

Model prodrugs designed for the intestinal peptide transporter. A synthetic approach for coupling of hydroxy-containing compounds to dipeptides.

Jan 2001

journal-article

Model prodrugs designed for the intestinal peptide transporter. A synthetic approach for coupling of hydroxy-containing compounds to dipeptides

European Journal of Pharmaceutical Sciences

Jan 2001

journal-article

Model prodrugs designed for the intestinal peptide transporter

European Journal of Pharmaceutical Sciences

Jan 2001

journal-article

Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line.

Jan 2001

journal-article

Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

American Journal of Physiology - Gastrointestinal and Liver Physiology

Jan 2001

journal-article

Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

American Journal of Physiology: Gastrointestinal and Liver Physiology

Jan 2001

journal-article

Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media.

Jan 2001

journal-article

Model prodrugs for the intestinal oligopeptide transporter: Model drug release in aqueous solution and in various biological media

Journal of Controlled Release

Jan 2001

journal-article

Model prodrugs for the intestinal oligopeptide transporter

Journal of Controlled Release

Jan 2001

journal-article

Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics.

Jan 2000

journal-article

Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics.

AAPS pharmSci [electronic resource]

Jan 2000

journal-article

Human proton/oligopeptide transporter (POT) genes

AAPS PharmSci

Jan 2000

journal-article

carsten uhd nielsen

Work

SDU

University of Southern Denmark

Education

The Royal Danish School of Pharmacy

The Royal Danish School of Pharmacy

Publications

Formulation Approaches for COVID-19 Vaccines

Fragment-Based Screening Identifies Novel Non-Amino Acid Inhibitors of the Sodium-Coupled Neutral Amino Acid Transporter SNAT2

Fragment-Based Screening Identifies Novel Non-Amino Acid Inhibitors of the Sodium-Coupled Neutral Amino Acid Transporter SNAT2

Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins

The oral bioavailability of a pleuromutilin antibiotic candidate is increased after co-administration with the CYP3A4 inhibitor ritonavir and the P-gp inhibitor zosuquidar formulated as amorphous solid dispersions

Screening of a fragment-based library uncovers novel scaffolds for inhibitors of the sodium-coupled neutral amino acid transporter SNAT2

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors

Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

The infectious capacity of Enterococcus faecalis, Staphylococcus aureus, and Staphylococcus saprophyticus in a porcine model of urinary tract infection

Structure-activity relationship of amino acid analogs to probe the binding pocket of sodium-coupled neutral amino acid transporter SNAT2

Digestion of surfactants does not affect their ability to inhibit P-gp-mediated transport in vitro

Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel bioavailability in rats

Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate

Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

Investigations of potential non-amino acid SNAT2 inhibitors.

Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells

Structure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains

Probing the Substrate Binding Site of SNAT2 With Amino Acid Analogues: A Structure-Activity Relationship Study

Increased bioavailability of a P-gp substrate

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Recent Advances in Photothermal Therapies Against Cancer and the Role of Membrane Transporter Modulators on the Efficacy of This Approach

Molecular Networks and Macromolecular Molar Mass Distributions for Preliminary Characterization of Danish Craft Beers

In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir

SNAT2 is responsible for hyperosmotic induced sarcosine and glycine uptake in human prostate PC-3 cells

P-glycoprotein-mediated transport in a mucus-supplemented Caco-2 cell model in the presence of different surfactants

Mechanism behind Polysorbates’ Inhibitory Effect on P-Glycoprotein

Mechanism behind polysorbates' inhibitory effect on P-glycoprotein

Molecular Networks and Macromolecular Molar Mass Distributions for Preliminary Characterization of Danish Craft Beers

Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition

Corrigendum to 'Is Oral Absorption of Vigabatrin Carrier-mediated?' [European Journal of Pharmaceutical Sciences 69 (2015) 10-18]

Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films

Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films

Inhibitory effects of 17-α-ethinyl-estradiol and 17-β-estradiol on transport via the intestinal proton-coupled amino acid transporter (PAT1) investigated In vitro and in vivo

BeerMIMS

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties

Evaluation of P-glycoprotein efflux activity and cellular toxicity in MDCKII MDR1 cells in a one-pot assay

Zosuquidar alters etoposide permeability across Caco-2 cell monolayers by P-glycoprotein inhibition in a concentration-dependent manner

Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA

Microenvironmental pH modifying films for buccal delivery of saquinavir

High-dose etoposide formulations do not saturate intestinal P-glycoprotein

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Etoposide transport in MDCKII-MRP2 cells is unaffected by P-gp expression and commonly used pharmaceutical excipients

Transcriptome analysis identifies activated signaling pathways and regulated ABC transporters and solute carriers after hyperosmotic stress in renal MDCK I cells

Transcriptome analysis identifies activated signaling pathways and regulated ABC transporters and solute carriers after hyperosmotic stress in renal MDCK I cells

The permeation of acamprosate is predominantly caused by paracellular diffusion across Caco-2 cell monolayers

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport

Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport

Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC)

MRP2-mediated transport of etoposide in MDCKII MRP2 cells is unaffected by commonly used non-ionic surfactants

Nfat5 is involved in the hyperosmotic regulation of Tmem184b: a putative modulator of ibuprofen transport in renal MDCK I cells

Nfat5 is involved in the hyperosmotic regulation of Tmem184b

Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1

Montmorillonite-surfactant hybrid particles for modulation of intestinal P-glycoprotein mediated transport

Amino acid transport in prostate PC-3 cells

Acamprosate permeability across Caco-2 cell monolayer is predominantly paracellular

Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells

How is sarcosine transported into prostate PC­‐3 cells?

Hyperosmolality regulates mRNA expression of membrane transporters in renal MDCK I cells

Nonionic surfactants alter calcein-AM efflux in MDCKII MDR1 cells

Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats

Glutamate Transporters in the Blood-Brain Barrier

Transport and metabolism of l‑glutamate in brain capillary endothelial cells and astrocytes

Oral and intravenous pharmacokinetics of taurine in sprague-dawley rats: the influence of dose and the possible involvement of the proton-coupled amino acid transporter, PAT1, in oral taurine absorption

Oral and intravenous pharmacokinetics of taurine in sprague-dawley rats

SGLT1-Mediated Transport in Caco-2 Cells Is Highly Dependent on Cell Bank Origin.

SGLT1-mediated transport in Caco-2 cells is highly dependent on cell bank origin

Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.

Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model

How is sarcosine transported into prostate PC‐3 cells?