Daniel Krappmann

Work

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt
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Director Signaling and Translation

Germany

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Publications

SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation

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Bioscience Reports

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Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

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Science Signaling

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Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas

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Blood

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Function and targeting of MALT1 paracaspase in cancer

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Cancer Treatment Reviews

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Human T<sub>H</sub>17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.

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Nature immunology

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Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1

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Science Advances

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Optimized CRISPR-Cas9-based Strategy for Complex Gene Targeting in Murine Embryonic Stem Cells for Germline Transmission.

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Bio-protocol

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Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells.

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Science signaling

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A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.

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Cellular and molecular life sciences : CMLS

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A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

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Cellular and Molecular Life Sciences

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Microbial dysbiosis in a mouse model of atopic dermatitis mimics shifts in human microbiome and correlates with the key pro-inflammatory cytokines IL-4, IL-33 and TSLP.

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Journal of the European Academy of Dermatology and Venereology : JEADV

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Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency.

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Journal of clinical immunology

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A proteome-scale map of the SARS-CoV-2-human contactome.

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Nature biotechnology

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Combining precision oncology and immunotherapy by targeting the MALT1 protease.

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Journal for immunotherapy of cancer

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Combining precision oncology and immunotherapy by targeting the MALT1 protease

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Journal for ImmunoTherapy of Cancer

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Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of <i>MALT1</i>.

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Science advances

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A patent review of MALT1 inhibitors (2013-present).

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Expert opinion on therapeutic patents

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MALT1 Is a Targetable Driver of Epithelial-to-Mesenchymal Transition in Claudin-Low, Triple-Negative Breast Cancer.

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Molecular cancer research : MCR

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TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.

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Science immunology

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Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of <i>MALT1</i>

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preprint

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1

Summary

preprint

Methods to Study CARD11-BCL10-MALT1 Dependent Canonical NF-κB Activation in Jurkat T Cells.

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Methods in molecular biology (Clifton, N.J.)

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Use of Non-Natural Amino Acids for the Design and Synthesis of a Selective, Cell-Permeable MALT1 Activity-Based Probe.

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Journal of medicinal chemistry

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Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant.

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The Journal of allergy and clinical immunology

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Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.

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Molecular cell

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Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma

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Journal of Pathology

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MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells.

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Cell reports

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Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

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Nature Communications

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Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells (Leukemia, (2018), 32, 1, (214-223), 10.1038/leu.2017.275)

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Leukemia

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Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

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Nature Communications

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Regulation of the endosomal SNX27-retromer by OTULIN

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Nature communications

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BCL10-Bridging CARDs to immune activation

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Frontiers in Immunology

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BCL10-CARD11 fusion mimics an active CARD11 seed that triggers constitutive BCL10 oligomerization and lymphocyte activation

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Frontiers in Immunology

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GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10

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Scientific Reports

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MALT1 activation by TRAF6 needs neither BCL10 nor CARD11

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Biochemical and Biophysical Research Communications

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Molecular architecture and regulation of BCL10-MALT1 filaments

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Nature Communications

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S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

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Leukemia

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Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

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Journal of Biological Chemistry

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B-cell receptor–driven MALT1 activity regulates MYC signaling in mantle cell lymphoma

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Blood

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Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation

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Molecular Immunology

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YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

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eLife

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Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma

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Leukemia

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A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN

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Cell Chemical Biology

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YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

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eLife

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Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome

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Biological Chemistry

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Mechanisms of NF-κB deregulation in lymphoid malignancies

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Semin. Cancer Biol.

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Mechanisms of NF-κB deregulation in lymphoid malignancies

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Seminars in Cancer Biology

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Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas

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Oncogene

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Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation

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Biochemical Journal

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Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome

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ACS Medicinal Chemistry Letters

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Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome

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Biol. Chem.

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Alternative splicing of MALT1 controls signalling and activation of CD4 + T cells

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Nature Communications

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Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response

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Hepatology

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Development of new Malt1 inhibitors and probes

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Bioorganic and Medicinal Chemistry

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Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma

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Leukemia

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Inhibition of Canonical NF-κ B Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

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Scientific Reports

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Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas

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Chemistry and Biology

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Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma

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Oncotarget

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Detection of recombinant and cellular MALT1 paracaspase activity

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Methods in Molecular Biology

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book

In Vitro Detection of NEMO–Ubiquitin Binding using Delfia and Microscale Thermophoresis Assays

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Methods in Molecular Biology

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book

Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies

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Oncogene

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AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation

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Cell Communication and Signaling

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Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T<inf>H</inf>17 differentiation

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Nature Immunology

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MALT1 protease: Equilibrating immunity versus tolerance

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EMBO Journal

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Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

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Journal of Neuroinflammation

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Progressive stages of mitochondrial destruction caused by cell toxic bile salts

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Biochimica et Biophysica Acta - Biomembranes

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MALT1 paracaspase: A unique protease involved in B-cell lymphomagenesis

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Int. J. Hematol. Oncol.

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Shaping oncogenic NF-κB activity in the nucleus

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Blood

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Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

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Angewandte Chemie - International Edition

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journal-article

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

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Molecular Cell

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XOTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin

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Cell

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Attacking MALT1 for ABC-DLBCL therapy.

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Oncotarget

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A20 and CYLD do not share significant overlapping functions during B cell development and activation

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Journal of Immunology

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Attacking MALT1 for ABC-DLBCL therapy

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Oncotarget

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Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

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Cancer Cell

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Critical role of PI3K signaling for NF-κB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells

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Proceedings of the National Academy of Sciences of the United States of America

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Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

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EMBO Journal

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Dlg3 Trafficking and apical tight junction formation is regulated by Nedd4 and Nedd4-2 E3 Ubiquitin ligases

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Developmental Cell

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NF-κB essential modulator (NEMO) interaction with linear and Lys-63 ubiquitin chains contributes to NF-κB activation

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Journal of Biological Chemistry

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Signals from the nucleus: Activation of NF-κB by cytosolic ATM in the DNA damage response

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Science Signaling

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The Ca2+-dependent phosphatase calcineurin controls the formation of the Carma1-Bcl10-Malt1 complex during T cell receptor-induced NF-κB activation

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Journal of Biological Chemistry

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Ubiquitin conjugation and deconjugation in nf-κb signaling

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Sub-Cellular Biochemistry

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A20 negatively regulates T cell receptor signaling to NF-κB by cleaving Malt1 ubiquitin chains

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Journal of Immunology

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COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation

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EMBO Reports

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Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells

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Journal of Experimental Medicine

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Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells (Journal of Experimental Medicine (2009) 206, 11 (2313-2320))

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Journal of Experimental Medicine

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Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation

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American Journal of Respiratory and Critical Care Medicine

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The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

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Nature Cell Biology

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Dynamic protein complexes regulate NF-kappaB signaling.

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Handbook of experimental pharmacology

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Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells

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FEBS Lett.

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journal-article

Dynamic protein complexes regulate NF-κB signaling

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Handbook of Experimental Pharmacology

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book

CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB.

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Science's STKE : signal transduction knowledge environment

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journal-article

MALT1 directs B cell receptor-induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

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Nature Immunology

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Malt1 ubiquitination triggers NF-κB signaling upon T-cell activation

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EMBO Journal

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Parkin mediates neuroprotection through activation of IκB kinase/nuclear factor-κB signaling

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Journal of Neuroscience

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Controlling NF-κB activation in T cells by costimulatory receptors

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Cell Death and Differentiation

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Essential Role for IκB Kinase β in Remodeling Carma1-Bcl10-Malt1 Complexes upon T Cell Activation

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Molecular Cell

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journal-article

A pervasive role of ubiquitin conjugation in activation and termination of IκB kinase pathways

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EMBO Reports

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Viral targeting of the interferon-β-inducing Traf family member-associated NF-κB activator (TANK)-binding kinase-1

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Proceedings of the National Academy of Sciences of the United States of America

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Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling

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Molecular and Cellular Biology

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Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation

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Oncogene

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The IκB kinase complex and NF-κB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1

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Molecular and Cellular Biology

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Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism

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EMBO Reports

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Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-κB

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EMBO Journal

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Nuclear factor κb-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

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Journal of Experimental Medicine

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Purification and characterization of the human elongator complex

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Journal of Biological Chemistry

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B-cell receptor- and phorbol ester-induced NF-κB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's

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Molecular and Cellular Biology

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Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

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Blood

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In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-κB activity

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Leukemia

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Shared pathways of IκB kinase-induced SCFβTrCP-mediated ubiquitination and degradation for the NF-κB precursor p105 and IκBα

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Molecular and Cellular Biology

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Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

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American Journal of Human Genetics

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Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

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Leukemia

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NF-κB and the innate immune response

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Current Opinion in Immunology

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The IκB kinase (IKK) complex is tripartite and contains IKKγ but not IKAP as a regular component

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Journal of Biological Chemistry

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Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells

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Leukemia

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Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.

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Blood

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NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition.

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Molecular and cellular biology

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Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

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Oncogene

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NF-κB function in growth control: Regulation of cyclin D1 expression and G<inf>0</inf>/G<inf>1</inf>-to-S-phase transition

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Molecular and Cellular Biology

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NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-p50 complexes

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EMBO Journal

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Overexpression of I kappa B alpha without inhibition of NF-κB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells

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Blood

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Signal-dependent degradation of IκBα is mediated by an inducible destruction box that can be transferred to NF-κB, Ecl-3 or p53

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Nucleic Acids Research

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Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

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The Journal of clinical investigation

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Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability.

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Immunobiology

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Constitutive nuclear factor-κb-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

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Journal of Clinical Investigation

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Regulation of NF-κB activity by IκBα and IκBβ stability

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Immunobiology

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Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo.

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The EMBO journal

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The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation.

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Journal of molecular medicine (Berlin, Germany)

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High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells.

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Blood

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Different mechanisms control signal-induced degradation and basal turnover of the NF-κB inhibitor IκBα in vivo

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EMBO Journal

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High-level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells

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Blood

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The NF-κB/Rel and IκB gene families: Mediators of immune response and inflammation

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Journal of Molecular Medicine

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