Daniel LaBarbera

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer

Cells

Jan 2025

journal-article

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer

Cells

Jan 2025

journal-article

CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models

International Journal of Molecular Sciences

Jan 2024

journal-article

CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models

International Journal of Molecular Sciences

Jan 2024

journal-article

Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine

Jan 2024

preprint

HTS discovery of PARP1-HPF1 complex inhibitors in cancer

SLAS Discovery

Jan 2023

journal-article

The validation of new CHD1L inhibitors as a therapeutic strategy for cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Jan 2023

journal-article

Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L.

Journal of medicinal chemistry

Jan 2022

journal-article

AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer.

International journal of molecular sciences

Jan 2022

journal-article

High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes.

International journal of molecular sciences

Jan 2022

journal-article

Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.

Free radical biology & medicine

Jan 2022

journal-article

TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer

Proceedings of the National Academy of Sciences

Jan 2021

journal-article

Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer.

Oncogene

Jan 2021

journal-article

Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo.

Molecular carcinogenesis

Jan 2021

journal-article

High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling.

Arteriosclerosis, thrombosis, and vascular biology

Jan 2020

journal-article

First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.

Molecular cancer therapeutics

Jan 2020

journal-article

Advanced High-Content-Screening Applications of Clonogenicity in Cancer.

SLAS discovery : advancing life sciences R & D

Jan 2020

journal-article

Advanced High-Content-Screening Applications of Clonogenicity in Cancer

SLAS Discovery

Jan 2020

journal-article

Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers.

Molecular cancer research : MCR

Jan 2019

journal-article

Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.

Journal of medicinal chemistry

Jan 2019

journal-article

Targeting HIV-1 Protease Autoprocessing for High-throughput Drug Discovery and Drug Resistance Assessment

Scientific Reports

Jan 2019

journal-article

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research

Jan 2018

journal-article

Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme.

Antiviral research

Jan 2018

journal-article

Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme

Antiviral Research

Jan 2018

journal-article

Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds.

PloS one

Jan 2018

journal-article

SBI² HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.

Assay and drug development technologies

Jan 2017

journal-article

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.

PLoS neglected tropical diseases

Jan 2017

journal-article

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri

PLOS Neglected Tropical Diseases

Jan 2017

journal-article

Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells.

Oncogene

Jan 2017

journal-article

3D High-Content Screening of Organoids for Drug Discovery

Comprehensive Medicinal Chemistry III

Jan 2017

book-chapter

High-throughput imaging: Focusing in on drug discovery in 3D

Methods

Jan 2016

journal-article

3D Cellular Imaging – Advances and Considerations for High-Content Screening

Drug Discovery World

Jan 2016

magazine-article

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract.

Journal of natural products

Jan 2016

journal-article

Topoisomerase IIα mediates TCF-dependent epithelial-mesenchymal transition in colon cancer.

Oncogene

Jan 2016

journal-article

High-throughput imaging: Focusing in on drug discovery in 3D.

Methods (San Diego, Calif.)

Jan 2015

journal-article

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.

Journal of medicinal chemistry

Jan 2015

journal-article

ChemInform Abstract: The Synthesis of Vinylogous Amidine Heterocycles.

ChemInform

Jan 2014

journal-article

Live multicellular tumor spheroid models for high-content imaging and screening in cancer drug discovery.

Current chemical genomics and translational medicine

Jan 2014

journal-article

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.

Chemico-biological interactions

Jan 2014

journal-article

An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent.

Marine drugs

Jan 2014

journal-article

Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.

Investigative ophthalmology & visual science

Jan 2014

journal-article

The synthesis of vinylogous amidine heterocycles.

The Journal of organic chemistry

Jan 2013

journal-article

Neoamphimedine, a Lead Anti-Metastatic Agent for the Treatment of Drug Resistant and Metastatic Colorectal Cancer

Planta Medica

Jan 2013

journal-article

Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase.

Journal of medicinal chemistry

Jan 2013

journal-article

The Synthesis of Vinylogous Amidine Heterocycles

The Journal of Organic Chemistry

Jan 2013

journal-article

The multicellular tumor spheroid model for high-throughput cancer drug discovery.

Expert opinion on drug discovery

Jan 2012

journal-article

The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

PloS one

Jan 2012

journal-article

Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues.

Chemico-biological interactions

Jan 2012

journal-article

Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties.

Hormones & cancer

Jan 2012

journal-article

A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer.

Journal of biomolecular screening

Jan 2012

journal-article

Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition.

Marine drugs

Jan 2011

journal-article

3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen.

Journal of biomolecular screening

Jan 2011

journal-article

The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells.

Anti-cancer drugs

Jan 2009

journal-article

ChemInform Abstract: The Total Synthesis of Neoamphimedine.

ChemInform

Jan 2008

journal-article

Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.

Journal of medicinal chemistry

Jan 2008

journal-article

Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products.

Journal of medicinal chemistry

Jan 2007

journal-article

Halogenated cyclic peptides isolated from the sponge Corticium sp.

Journal of natural products

Jan 2007

journal-article

The total synthesis of neoamphimedine.

The Journal of organic chemistry

Jan 2007

journal-article

Solution kinetics of CC-1065 A-ring opening: substituent effects and general acid/base catalysis.

Journal of the American Chemical Society

Jan 2006

journal-article

Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products.

Bioorganic & medicinal chemistry

Jan 2005

journal-article

Daniel LaBarbera

Work

University of Colorado Anschutz Medical Campus

Education

University of Utah

Arizona State University

Publications

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer

CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models

CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models

Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine

HTS discovery of PARP1-HPF1 complex inhibitors in cancer

The validation of new CHD1L inhibitors as a therapeutic strategy for cancer.

Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L.

AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer.

High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes.

Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.

TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer

Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer.

Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo.

High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling.

First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.

Advanced High-Content-Screening Applications of Clonogenicity in Cancer.

Advanced High-Content-Screening Applications of Clonogenicity in Cancer

Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers.

Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.

Targeting HIV-1 Protease Autoprocessing for High-throughput Drug Discovery and Drug Resistance Assessment

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.

Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme.

Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme

Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds.

SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri

Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells.

3D High-Content Screening of Organoids for Drug Discovery

High-throughput imaging: Focusing in on drug discovery in 3D

3D Cellular Imaging – Advances and Considerations for High-Content Screening

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract.

Topoisomerase IIα mediates TCF-dependent epithelial-mesenchymal transition in colon cancer.

High-throughput imaging: Focusing in on drug discovery in 3D.

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.

ChemInform Abstract: The Synthesis of Vinylogous Amidine Heterocycles.

Live multicellular tumor spheroid models for high-content imaging and screening in cancer drug discovery.

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.

An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent.

Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.

The synthesis of vinylogous amidine heterocycles.

Neoamphimedine, a Lead Anti-Metastatic Agent for the Treatment of Drug Resistant and Metastatic Colorectal Cancer

Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase.

The Synthesis of Vinylogous Amidine Heterocycles

The multicellular tumor spheroid model for high-throughput cancer drug discovery.

The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues.

Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties.

A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer.

Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition.

3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen.

The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells.

ChemInform Abstract: The Total Synthesis of Neoamphimedine.

Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.

Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products.

Halogenated cyclic peptides isolated from the sponge Corticium sp.

The total synthesis of neoamphimedine.

Solution kinetics of CC-1065 A-ring opening: substituent effects and general acid/base catalysis.

Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products.

SBI² HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.