Eileen Kennedy

Work

University of North Carolina at Chapel Hill
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Division Chair, Eshelman Distinguished Professor

US

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University of Georgia
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Georgia Athletic Association Professor

US

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University of Georgia
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Associate Professor

US

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University of Georgia
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Assistant Professor

US

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Education

Harvard University
United States of America

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Postdoctroal Fellow

University of California, San Diego
United States of America

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PhD

University of Washington
United States of America

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BS

Publications

Development of an All-Hydrocarbon Stapled Peptide Targeting BRK1 in Triple-Negative Breast Cancer

Published by

ACS Medicinal Chemistry Letters

Summary

journal-article

Anionic lipids direct efficient microfluidic encapsulation of stable and functionally active proteins in lipid nanoparticles

Published by

Communications Materials

Summary

journal-article

Disruption of the LRRK2‐FADD Interface Using Constrained Peptides

Published by

Peptide Science

Summary

journal-article

Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC

Published by

ACS Chemical Biology

Summary

journal-article

Targeting Rab‐RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease

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Journal of Peptide Science

Summary

journal-article

Targeting Rab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson’s Disease

Summary

preprint

In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer

Published by

ACS Medicinal Chemistry Letters

Summary

journal-article

Leucine rich repeat kinase 2 (LRRK2) peptide modulators: Recent advances and future directions

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Peptide Science

Summary

journal-article

Targeted disruption of PKC from AKAP signaling complexes

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RSC Chemical Biology

Summary

journal-article

Targeting Plasmodium with constrained peptides and peptidomimetics

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IUBMB Life

Summary

journal-article

Twist, Snail, and Sox9 form an allosterically regulated complex, the EMTosome, on a bipartite E-box site

Summary

preprint

A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A

Published by

Molecules

Summary

journal-article

A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A

Published by

Molecules

Summary

journal-article

Targeted Inhibition of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 with a Constrained J Domain-Derived Disruptor Peptide

Published by

ACS Infectious Diseases

Summary

journal-article

PKA‐mediated phosphorylation of NKD2 stimulates cell‐surface delivery of TGF‐α for EGFR transactivation

Summary

journal-article

Protein kinase A‐mediated phosphorylation of naked cuticle homolog 2 stimulates cell‐surface delivery of transforming growth factor‐α for epidermal growth factor receptor transactivation

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Traffic

Summary

journal-article

Constrained peptides and biological targets.

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Bioorganic & medicinal chemistry

Summary

journal-article

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.

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The EMBO journal

Summary

journal-article

Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2.

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Bioorganic & medicinal chemistry

Summary

journal-article

Cell penetrating peptides to dissect host-pathogen protein-protein interactions in Theileria-transformed leukocytes.

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Bioorganic & medicinal chemistry

Summary

journal-article

Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.

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Bioorganic & medicinal chemistry

Summary

journal-article

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss.

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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Summary

journal-article

Molecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.

Published by

JCO precision oncology

Summary

journal-article

Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex.

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Cancer growth and metastasis

Summary

journal-article

Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution.

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Nature methods

Summary

journal-article

Targeting kinase signaling pathways with constrained peptide scaffolds.

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Pharmacology & therapeutics

Summary

journal-article

HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocytes.

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ACS infectious diseases

Summary

journal-article

PKA and Apicomplexan Parasite Diseases.

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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Summary

journal-article

PKA and Apicomplexan Parasite Diseases.

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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Summary

journal-article

Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

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PLoS genetics

Summary

journal-article

The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis.

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Cancer research

Summary

journal-article

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.

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The Biochemical journal

Summary

journal-article

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Published by

PLoS genetics

Summary

journal-article

Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.

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The Journal of neuroscience : the official journal of the Society for Neuroscience

Summary

journal-article

PKA-type I selective constrained peptide disruptors of AKAP complexes.

Published by

ACS chemical biology

Summary

journal-article

Defining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI).

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Chembiochem : a European journal of chemical biology

Summary

journal-article

Targeting the WASF3-CYFIP1 Complex Using Stapled Peptides Suppresses Cancer Cell Invasion.

Published by

Cancer research

Summary

journal-article

Lysophosphatidic Acid Mediates Activating Transcription Factor 3 Expression Which Is a Target for Post-Transcriptional Silencing by miR-30c-2-3p.

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PloS one

Summary

journal-article

Dialing in EGFR Signaling.

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Chemistry & biology

Summary

journal-article

The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism.

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PloS one

Summary

journal-article

Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein.

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Biochimica et biophysica acta

Summary

journal-article

Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.

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Biochimica et biophysica acta

Summary

journal-article

Design of a selenylsulfide-bridged EGFR dimerization arm mimic.

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Bioorganic & medicinal chemistry

Summary

journal-article

Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics.

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PloS one

Summary

journal-article

Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells.

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Molecular and cellular endocrinology

Summary

journal-article

Selective disruption of the AKAP signaling complexes.

Published by

Methods in molecular biology (Clifton, N.J.)

Summary

journal-article

EMBO conference series: Chemical Biology 2014.

Published by

Chembiochem : a European journal of chemical biology

Summary

journal-article

Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides.

Published by

ACS chemical biology

Summary

journal-article

Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue.

Published by

PloS one

Summary

journal-article

Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides.

Published by

ACS chemical biology

Summary

journal-article

Identifying critical non-catalytic residues that modulate protein kinase A activity.

Published by

PloS one

Summary

journal-article

Contribution of non-catalytic core residues to activity and regulation in protein kinase A.

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The Journal of biological chemistry

Summary

journal-article

Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2.

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The Journal of biological chemistry

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journal-article

Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae.

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Eukaryotic cell

Summary

journal-article

Induction of donor-specific tolerance to islet allografts in nonhuman primates.

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Annals of the New York Academy of Sciences

Summary

journal-article

Induction of islet allotolerance in nonhuman primates.

Published by

Annals of the New York Academy of Sciences

Summary

journal-article