Gerrit Hilgen

About

Gerrit's research focuses on neuronal signal processing, imaging, and scientific computing, particularly in the mature and neonatal retina, human retinal organoids, and their relation to health and disease. Gerrit is involved in projects funded by MRC, Wellcome Trust, and the Academy of Medical Science, focusing on restoring vision, studying hypersensitivity to evening light in bipolar disorder patients, and understanding ocular channelopathies. He aims to establish a leading laboratory integrating neuroscience, cellular imaging, multi-omics, and computational approaches. Gerrit also co-leads the Translational Bioscience research theme and promotes collaborations within the university in neuroscience, organoid and microscopy sciences.

Education

Carl von Ossietzky Universität Oldenburg
Germany

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Doctor rerum naturalium (equiv. to PhD)

Carl von Ossietzky Universität Oldenburg
Germany

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Diplom Biologe

Publications

Photostimulation Improves Maturation of Human Photoreceptors

Summary

preprint

Evaluating the outcomes of pluripotent stem‐cell‐derived photoreceptor transplantation in retinal repair

Published by

The FEBS Journal

Summary

journal-article

Investigating light sensitivity in bipolar disorder (HELIOS-BD)

Published by

Wellcome Open Research

Summary

journal-article

How Does the Inner Retinal Network Shape the Ganglion Cells Receptive Field? A Computational Study

Published by

Neural Computation

Summary

journal-article

Connexin45 colocalization patterns in the plexiform layers of the developing mouse retina

Published by

Journal of Anatomy

Summary

journal-article

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids

Published by

Journal of Cellular and Molecular Medicine

Summary

journal-article

Connexin45 colocalization patterns in the plexiform layers of the developing mouse retina

Published by

Journal of Anatomy

Summary

journal-article

A novel approach to the functional classification of retinal ganglion cells

Published by

Open Biology

Summary

journal-article

A novel approach to the functional classification of retinal ganglion cells

Published by

Open Biology

Summary

journal-article

Receptive field estimation in large visual neuron assemblies using a super-resolution approach

Published by

Journal of Neurophysiology

Summary

journal-article

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations

Published by

Stem cells translational medicine

Summary

journal-article

Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration.

Published by

Stem cells (Dayton, Ohio)

Summary

journal-article

A novel approach to the functional classification of retinal ganglion cells

Summary

preprint

Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

Published by

Stem Cells

Summary

journal-article

Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids

Published by

PLoS One

Summary

journal-article

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent

Published by

Stem Cells

Summary

journal-article

Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

Summary

preprint

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent

Published by

Stem Cells

Summary

journal-article

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids

Published by

Biomaterials

Summary

journal-article

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

Published by

Stem cells translational medicine

Summary

journal-article

Challenges for automated spike sorting: beware of pharmacological manipulations

Summary

preprint

Challenges for automated spike sorting

Published by

Arxiv

Summary

other

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids

Published by

Biomaterials

Summary

journal-article

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

Published by

Stem Cells Translational Medicine

Summary

journal-article

Effects of Touch Location and Intensity on Interneurons of the Leech Local Bend Network

Published by

Scientific Reports

Summary

journal-article

Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency.

Published by

Stem cells (Dayton, Ohio)

Summary

journal-article

Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency

Published by

Stem Cells

Summary

journal-article

Automatic segmentation of neurons from fluorescent microscopy imaging

Published by

Communications in Computer and Information Science

Summary

book

Automatic segmentation of neurons from fluorescent microscopy imaging

Published by

Biomedical Engineering Systems and Technologies - 10th International Joint Conference, BIOSTEC 2017, Revised Selected Papers

Summary

conference-paper

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa

Published by

Nature Communications

Summary

journal-article

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa

Published by

Nature Communications

Summary

journal-article

Effects of Touch Location and Intensity on Interneurons of the Leech Local Bend Network

Published by

Scientific Reports

Summary

journal-article

Higher network activity induced by tactile compared to electrical stimulation of leech mechanoreceptors

Published by

Frontiers in Physiology

Summary

journal-article

Higher network activity induced by tactile compared to electrical stimulation of leech mechanoreceptors

Published by

Frontiers in Physiology

Summary

journal-article

Non-parametric physiological classification of retinal ganglion cells in the mouse retina

Published by

Frontiers in Cellular Neuroscience

Summary

journal-article

Non-parametric physiological classification of retinal ganglion cells in the mouse retina

Published by

Frontiers in Cellular Neuroscience

Summary

journal-article

Segmentation of retinal ganglion cells from fluorescent microscopy imaging

Published by

BIOIMAGING 2017 - 4th International Conference on Bioimaging, Proceedings; Part of 10th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2017

Summary

conference-paper

Segmentation of retinal ganglion cells from fluorescent microscopy imaging

Published by

BIOIMAGING 2017 - 4th International Conference on Bioimaging, Proceedings

Summary

conference-paper

Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrays

Published by

Cell Reports

Summary

journal-article

Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrays

Published by

Cell Reports

Summary

journal-article

Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Published by

Scientific Reports

Summary

journal-article

Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Published by

Scientific Reports

Summary

journal-article

Encoding of tactile stimuli by mechanoreceptors and interneurons of the medicinal leech

Published by

Frontiers in Physiology

Summary

journal-article

Pan-Retinal Characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Summary

preprint

Pan-Retinal Characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Summary

other

Unsupervised spike sorting for large scale, high density multielectrode arrays

Summary

preprint

Dampening spontaneous activity improves the light sensitivity and spatial acuity of optogenetic retinal prosthetic responses

Published by

Scientific Reports

Summary

journal-article

Dampening spontaneous activity improves the light sensitivity and spatial acuity of optogenetic retinal prosthetic responses

Published by

Scientific Reports

Summary

journal-article

Encoding of tactile stimuli by mechanoreceptors and interneurons of the medicinal leech

Published by

Frontiers in Physiology

Summary

journal-article

Rank order coding: A retinal information decoding strategy revealed by large-scale multielectrode array retinal recordings

Published by

eNeuro

Summary

journal-article

Rank Order Coding: a Retinal Information Decoding Strategy Revealed by Large-Scale Multielectrode Array Retinal Recordings

Published by

eneuro

Summary

journal-article

Rank order coding

Published by

eNeuro

Summary

journal-article

Encoding of tactile stimuli by mechanoreceptors and interneurons of the medicinal leech

Published by

Frontiers in Physiology

Summary

journal-article

A super-resolution approach for receptive fields estimation of neuronal ensembles.

Published by

BMC neuroscience

Summary

journal-article

AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions.

Summary

journal-article

All amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions

Published by

Journal of Cell Science

Summary

journal-article

All amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions

Published by

Journal of Cell Science

Summary

journal-article

Removing bleaching artifacts from voltage sensitive dye recordings with ICA.

Summary

journal-article

Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina.

Summary

journal-article

Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina

Published by

PLoS ONE

Summary

journal-article

Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina

Published by

PLoS One

Summary

journal-article

Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina.

Summary

journal-article

Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina

Published by

Journal of Comparative Neurology

Summary

journal-article

Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina

Published by

Journal of Comparative Neurology

Summary

journal-article

Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light.

Summary

journal-article

Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light

Published by

Journal of Comparative Neurology

Summary

journal-article

Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light

Published by

Journal of Comparative Neurology

Summary

journal-article