Giselda Bucca

About

I started my career in Italy where I completed my PhD on the heat shock response in Streptomyces bacteria. In 1989 I moved to Manchester (UK) as a Postdoc working at UMIST (now part of the University of Manchester) in the laboratory directed by Prof Colin Smith. I was promoted to Research Fellow in 1997 and in 2003 I obtained a permanent position as a Research Fellow/Laboratory manager at the Faculty of Health and Medical Sciences, University of Surrey, Guildford. Together with Prof. Colin Smith we established a Functional Genomics Facility at the University of Surrey where we established a successful interdiscliplinary collaboration with sleep researchers. At the same time we were the worldwide provider of Streptomyces DNA microarrays which were printed in our Core Facility. We hosted many international visitors that came to our lab to learn about Genomics techniques applied to Streptomyces (transcriptomics and Chip-on chip). In 2016 both myself and Prof Colin Smith were appointed at the University of Brighton to establish a Core Genomics Facility. I was appointed as a Senior Research Fellow for a short term contract in order to help establish the new facility and in 2017 I was appointed as a Genomics Experimental Officer on a permanent contract. In October 2021 I was promoted to Research Fellow and continue my role in supporting the experimental side of activities at Brighton Genomics, together with Dr Andy Hesketh who is the Bioinformatician supporting the facility. We have established a number of research collaborations within our University and at BSMS and continue our external collaborations with nutritional scientists at the University of Surrey and immunologists at KCL/KCH (as part of COG-UK consortium). In 2019 I was presented with the title of 'Commendatore OMRI' for promoting Anglo-Italian scientific relationships by the Italian UK Ambassador at the Italian Embassy in London .

Work

King's College London
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Visiting Senior Research Fellow

United Kingdom of Great Britain and Northern Ireland

University of Brighton

United Kingdom of Great Britain and Northern Ireland

University of Brighton
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Research Fellow

United Kingdom of Great Britain and Northern Ireland

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University of Brighton
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Genomics Experimental Officer (permanent position)

United Kingdom of Great Britain and Northern Ireland

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University of Brighton
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Senior Research Fellow

United Kingdom of Great Britain and Northern Ireland

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University of Surrey
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Research Fellow (permanent position)

United Kingdom of Great Britain and Northern Ireland

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University of Manchester
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Post Doc

United Kingdom of Great Britain and Northern Ireland

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Education

University of Palermo
Italy

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PhD (Molecular Genetics)

University of Palermo
Italy

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Biological Science

Publications

The effects of physiological and injurious hydrostatic pressure on murine ex vivo articular and growth plate cartilage explants

Published by

Frontiers in Endocrinology

Summary

journal-article

Development of theranostic wound dressings

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Expert Review of Medical Devices

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other

Positive resolution of the wound-healing response in lens epithelial cells by Ti 3 C 2 T x MXene coatings for use in accommodative intraocular lens devices

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2D Materials

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journal-article

Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

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cancers

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journal-article

Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome

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Frontiers in Immunology

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journal-article

Chemotranscriptomic Profiling Defines Drug-Specific Signatures of the Glycopeptide Antibiotics Dalbavancin, Vancomycin and Chlorobiphenyl-Vancomycin in a VanB-Type-Resistant Streptomycete

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Frontiers in Microbiology

Summary

journal-article

Vitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line

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Molecular Medicine

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journal-article

Daily supplementation with 15 mg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: A 12-wk randomized, placebo-controlled food-fortification trial

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American Journal of Clinical Nutrition

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journal-article

Disruption of macrodomain protein SCO6735 increases antibiotic production in streptomyces coelicolor

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Journal of Biological Chemistry

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journal-article

The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)

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Nature Communications

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journal-article

A terD domain-encoding gene (SCO2368) is involved in calcium homeostasis and participates in calcium regulation of a DosR-like regulon in Streptomyces coelicolor

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Journal of Bacteriology

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journal-article

Exploiting human and mouse transcriptomic data: Identification of circadian genes and pathways influencing health

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BioEssays

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journal-article

Genome-wide analysis of in vivo binding of the master regulator DasR in streptomyces coelicolor identifies novel non-canonical targets

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PLoS ONE

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A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing

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Molecular Microbiology

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journal-article

Deciphering the regulon of Streptomyces coelicolor AbrC3, a positive response regulator of antibiotic production

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Applied and Environmental Microbiology

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journal-article

E-MTAB-2644 - Differential expression of S. coelicolor M145 vs. tdd8 mutants in R5

Summary

data-set

Mistimed sleep disrupts circadian regulation of the human transcriptome

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Proceedings of the National Academy of Sciences of the United States of America

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journal-article

Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome

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Proceedings of the National Academy of Sciences of the United States of America

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journal-article

Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome

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Proceedings of the National Academy of Sciences of the United States of America

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journal-article

Identification of new developmentally regulated genes involved in Streptomyces coelicolor sporulation

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BMC Microbiology

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journal-article

The ROK Family regulator rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression, and antibiotic production in Streptomyces coelicolor

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Journal of Bacteriology

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journal-article

Comparison of vitamin D<inf>2</inf>and vitamin D<inf>3</inf> supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-analysis

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American Journal of Clinical Nutrition

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journal-article

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status

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American Journal of Clinical Nutrition

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journal-article

Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: Genome-wide identification of in vivo targets

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Nucleic Acids Research

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Genome-wide transcriptomic analysis of the response to nitrogen limitation in Streptomyces coelicolor A3(2)

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BMC Research Notes

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Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization

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BMC Genomics

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journal-article

A gene expression profiling approach assessing celecoxib in a randomized controlled trial in prostate cancer

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Cancer Genomics and Proteomics

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journal-article

Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon.

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Genome biology

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journal-article

NepA is a structural cell wall protein involved in maintenance of spore dormancy in Streptomyces coelicolor

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Molecular Microbiology

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journal-article

One of the two genes encoding nucleoid-associated HU proteins in Streptomyces coelicolor is developmentally regulated and specifically involved in spore maturation

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Journal of Bacteriology

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journal-article

New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures

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BMC Genomics

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journal-article

A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor

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Molecular Microbiology

Summary

journal-article

A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor

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Molecular Microbiology

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journal-article

An experimental evaluation of a loop versus a reference design for two-channel microarrays

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Bioinformatics

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journal-article

An experimental evaluation of a loop versus a reference design for two-channel microarrays

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Bioinformatics

Summary

journal-article

Gene expression profiling of human cancers

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Annals of the New York Academy of Sciences

Summary

book

Negative feedback regulation of dnaK, cIpB and ion expression by the DnaK chaperone machine in Streptomyces coelicolor, identified by transcriptome and in vivo DnaK-depletion analysis

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Molecular Microbiology

Summary

journal-article

Streptomyces coelicolor A3(2): from genome sequence to function

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Methods in Microbiology

Summary

book

The HspR regulon of Streptomyces coelicolor: A role for the DnaK chaperone as a transcriptional co-repressor

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Molecular Microbiology

Summary

journal-article

Regulation of the dnaK operon of Streptomyces coelicolor A3(2) is governed by HspR, an autoregulatory repressor protein

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Journal of Bacteriology

Summary

journal-article

The dnaK operon of Streptomyces coelicolor encodes a novel heat‐shock protein which binds to the promoter region of the operon

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Molecular Microbiology

Summary

journal-article

Cloning and sequencing of the dnaK region of Streptomyces coelicolor A3(2)

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Gene

Summary

journal-article