Hao Chen

About

Dr. Hao Chen obtained his Ph.D. from the Chinese University of Hong Kong and is currently a professor at Guangzhou Medical University. His lab studies the physiology of the male reproductive system and related diseases associated with human infertility.

Work

Guangzhou Medical University
|

Professor

China

→

Nantong University
|

Professor

China

→

Publications

Blocking T-type calcium channels disrupts spermatogenesis in vivo and adversely affects spermatocytes in vitro by impairing mitochondrial function and autophagic flux

Published by

Reproductive Toxicology

Summary

journal-article

METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m6A methylation in humans and mice

Published by

Molecular Therapy

Summary

journal-article

Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales’s testis

Published by

Cell & Bioscience

Summary

journal-article

PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins

Published by

American Journal of Physiology-Cell Physiology

Summary

journal-article

Advances in Imaging Techniques for Mammalian/Human Ciliated Cell’s Cilia: Insights into Structure, Function, and Dynamics

Published by

Biology

Summary

journal-article

Advances in Imaging Techniques for Mammalian/Human Ciliated Cell’s Cilia: Insights into Structure, Function, and Dynamics

Published by

Biology

Summary

journal-article

In situ architecture of the intercellular organelle reservoir between epididymal epithelial cells by volume electron microscopy

Published by

Nature Communications

Summary

journal-article

Advancement and Potential Applications of Epididymal Organoids

Published by

Biomolecules

Summary

journal-article

Advancement and Potential Applications of Epididymal Organoids

Published by

Biomolecules

Summary

journal-article

Unraveling the ultrastructure and dynamics of autophagic vesicles: Insights from advanced imaging techniques

Published by

FASEB BioAdvances

Summary

journal-article

Unlocking Genetic Mysteries during the Epic Sperm Journey toward Fertilization: Further Expanding Cre Mouse Lines

Published by

Biomolecules

Summary

journal-article

Unlocking Genetic Mysteries during the Epic Sperm Journey toward Fertilization: Further Expanding <i>Cre</i> Mouse Lines

Published by

Biomolecules

Summary

journal-article

Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actin

Published by

Reproductive Biology and Endocrinology

Summary

journal-article

Exposure to Titanium Dioxide Nanoparticles Leads to Specific Disorders of Spermatid Elongation via Multiple Metabolic Pathways in <i>Drosophila</i> Testes

Published by

ACS Omega

Summary

journal-article

LncRNA USP2-AS1 facilitates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting KDM3A/ETS1/USP2 to activate the Wnt/β-catenin signaling pathway

Published by

RNA Biology

Summary

journal-article

Structure and molecular basis of spermatid elongation in the <i>Drosophila</i> testis

Published by

Open Biology

Summary

journal-article

Connecting the Dots: N6‐Methyladenosine (m6A) Modification in Spermatogenesis

Published by

Advanced Biology

Summary

journal-article

Cadmium-induced Sertoli Cell Injury Through p38-MAPK and Related Signaling Proteins—A Study by RNA Sequencing

Published by

Endocrinology

Summary

journal-article

Epididymis cell atlas in a patient with a sex development disorder and a novel NR5A1 gene mutation

Published by

Asian Journal of Andrology

Summary

journal-article

SARS-CoV-2 and male infertility: from short- to long-term impacts

Published by

Journal of Endocrinological Investigation

Summary

journal-article

SARS-CoV-2 and male infertility: from short- to long-term impacts

Published by

Journal of Endocrinological Investigation

Summary

journal-article

β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility

Published by

Cell Reports Medicine

Summary

journal-article

Defb19 regulates the migration of germ cell and is involved in male fertility

Published by

Cell & Bioscience

Summary

journal-article

CSE1L/CAS regulates cell proliferation through CDK signalling in mouse spermatogenesis

Published by

Cell Proliferation

Summary

journal-article

The N501Y Mutation of SARS-CoV-2 Spike Protein Impairs Spindle Assembly in Mouse Oocytes

Published by

Reproductive Sciences

Summary

journal-article

Interfering with CSE1L/CAS inhibits tumour growth via C3 in triple‐negative breast cancer

Published by

Cell Proliferation

Summary

journal-article

Cell-Cell Interaction-Mediated Signaling in the Testis Induces Reproductive Dysfunction-Lesson from the Toxicant/Pharmaceutical Models

Published by

Cells

Summary

journal-article

The effects of thirdhand smoke on reproductive health

Published by

Journal of Applied Toxicology

Summary

journal-article

The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis

Published by

BMC Biology

Summary

journal-article

CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia

Published by

Molecular Therapy - Nucleic Acids

Summary

journal-article

Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq

Published by

Cell Discovery

Summary

journal-article

Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq

Published by

Cell Discovery

Summary

journal-article

Epididymal initial segment-specific Cre recombinase activity in Lcn8-Cre knock-in mice

Published by

Molecular Biology Reports

Summary

journal-article

Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1

Published by

Medical Oncology

Summary

journal-article

An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction

Published by

Science China Life Sciences

Summary

journal-article

The landscape of mouse epididymal cells defined by the single-cell RNA-Seq

Summary

preprint

Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes

Published by

Gut

Summary

journal-article

Expression of cellular apoptosis susceptibility (CAS) in the human testis and testicular germ cell tumors

Published by

Medical Oncology

Summary

journal-article

Defective CFTR promotes intestinal proliferation via inhibition of the hedgehog pathway during cystic fibrosis

Published by

Cancer Letters

Summary

journal-article

MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer

Published by

Theranostics

Summary

journal-article

CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/β-Catenin Complex in Human Endometriosis

Published by

The American Journal of Pathology

Summary

journal-article

CCR6 is required for ligand-induced CatSper activation in human sperm

Published by

Oncotarget

Summary

journal-article

Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migration

Published by

Oncotarget

Summary

journal-article

CD147 regulates extrinsic apoptosis in spermatocytes by modulating NF kappa B signaling pathways

Published by

Oncotarget

Summary

journal-article

Generation of scFv specific to human VEGFR-3 from the neutralizing mAb BDD073

Published by

Protein Engineering Design and Selection

Summary

journal-article

Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis

Published by

Journal of Clinical Endocrinology &amp; Metabolism

Summary

journal-article

Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection

Published by

Science Translational Medicine

Summary

journal-article

Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells

Published by

Fertility and Sterility

Summary

journal-article

Novel regulators of spermatogenesis

Published by

Seminars in Cell &amp; Developmental Biology

Summary

journal-article

Reconstitution of coronary vasculature by an active fraction of Geum japonicum in ischemic hearts

Published by

Scientific Reports

Summary

journal-article

Decreased expression of cystic fibrosis transmembrane conductance regulator impairs sperm quality in aged men

Published by

Reproduction

Summary

journal-article

Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer

Published by

Biochimica Et Biophysica Acta-Molecular Cell Research

Summary

journal-article

Inhibition of angiogenesis by a novel neutralizing antibody targeting human VEGFR-3

Published by

Mabs

Summary

journal-article

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

Published by

Nature Genetics

Summary

journal-article

New insights into germ cell migration and survival/apoptosis in spermatogenesis

Published by

Spermatogenesis

Summary

journal-article

CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia

Published by

Human Reproduction

Summary

journal-article

Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing

Published by

Journal of Cellular Physiology

Summary

journal-article

Reconstitution of coronary vasculature in ischemic hearts by plant-derived angiogenic compounds

Published by

International Journal of Cardiology

Summary

journal-article

STK31 Maintains the Undifferentiated State of Colon Cancer Cells

Published by

Carcinogenesis

Summary

journal-article

CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis

Published by

Molecular Human Reproduction

Summary

journal-article

Lymphocytes Accelerate Epithelial Tight Junction Assembly: Role of AMP-Activated Protein Kinase (AMPK)

Published by

Plos One

Summary

journal-article

A Plant-Derived Remedy for Repair of Infarcted Heart

Published by

Plos One

Summary

journal-article