Jordi Garcia Gomez

New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells

Pharmaceuticals

Jan 2025

journal-article

New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells

Pharmaceuticals

Jan 2025

journal-article

Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells

Biomaterials Science

Jan 2021

journal-article

Degradation of Fatty Acid Phase-Change Materials (PCM): New Approach for Its Characterization

Molecules

Jan 2021

journal-article

Degradation of Fatty Acid Phase-Change Materials (PCM): New Approach for Its Characterization

Molecules

Jan 2021

journal-article

Pyridine- and Quinoline-Derived Imines as N,N-Bidentate Directing Groups in Palladium versus Platinum C–H Bond Activation Reactions

Organometallics

Jan 2021

journal-article

A New Nanomedicine Platform to Deliver a Carnitine Palmitoyl-Transferase 1 (CPT1) Inhibitor into Glioma Cells and Neurons

Jan 2020

conference-paper

An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (S)-5-(tert-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid

Molecules

Jan 2020

journal-article

An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (S)-5-(tert-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid

Molecules

Jan 2020

journal-article

An Overview of Nanomedicines for Neuron Targeting

Nanomedicine

Jan 2020

journal-article

Access to indolines from primary phenylethylamines by an unexpected palladium-catalyzed C–H functionalization process

RSC Advances

Jan 2019

journal-article

Designed asymmetric coordination helicates with bis-β-diketonate ligands

Dalton Transactions

Jan 2019

journal-article

Preparation of Substituted Tetrahydroisoquinolines by Pd(II)-Catalyzed NH2-Directed Insertion of Michael Acceptors into C-H Bonds Followed by NH2-Conjugated Addition

Organometallics

Jan 2017

journal-article

(−)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

European Journal of Medicinal Chemistry

Jan 2017

journal-article

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

European Journal of Medicinal Chemistry

Jan 2017

journal-article

Preparation of Substituted Tetrahydroisoquinolines by Pd(II)-Catalyzed NH2-Directed Insertion of Michael Acceptors into C–H Bonds Followed by NH2-Conjugated Addition

Organometallics

Jan 2017

journal-article

A Useful Allene for the Stereoselective Synthesis of Protected Quaternary 2-Amino-2-vinyl-1,3-diols

The Journal of Organic Chemistry

Jan 2017

journal-article

A Useful Allene for the Stereoselective Synthesis of Protected Quaternary 2-Amino-2-vinyl-1,3-diols

Journal of Organic Chemistry

Jan 2017

journal-article

Chiral Induction in Intramolecular Rhodium-Catalyzed [2 + 2 + 2] Cycloadditions of Optically Active Allene–ene/yne–allene Substrates

advanced synthesis and catalysis

Jan 2017

journal-article

Chiral Induction in Intramolecular Rhodium-Catalyzed 2+2+2 Cycloadditions of Optically Active Allene-ene/yne-allene Substrates

Advanced Synthesis & Catalysis

Jan 2017

journal-article

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+breast cancer

Histology and Histopathology

Jan 2017

journal-article

Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism

Chemistry and physics of lipids

Jan 2017

journal-article

Multisensitive drug-loaded polyurethane/polyurea nanocapsules with pH-synchronized shell cationization and redox-triggered release

Polymer Chemistry

Jan 2016

journal-article

Multisensitive drug-loaded polyurethane/polyurea nanocapsules with pH-synchronized shell cationization and redox-triggered release

Polymer Chemistry

Jan 2016

journal-article

Molecular interplay between cancer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

European Journal of Cancer

Jan 2015

journal-article

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

International Journal of Cancer

Jan 2015

journal-article

Peptide-based chelating drugs in diagnosis and treatment of Alzheimer disease

Journal of Biological Inorganic Chemistry

Jan 2014

journal-article

Catalytic C H Activation of Phenylethylamines or Benzylamines and Their Annulation with Allenes

Journal of Organic Chemistry

Jan 2014

journal-article

Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

Aging-Us

Jan 2014

journal-article

Effect of carnitine palmitoyltransferase (CPT) 1A activity regulation on the control of the food intake

Diabetologia

Jan 2013

journal-article

Convenient synthesis of C75, an inhibitor of FAS and CPT1

Rsc Advances

Jan 2013

journal-article

Differential Pharmacologic Properties of the Two C75 Enantiomers: (+)-C75 Is a Strong Anorectic Drug; (-)-C75 Has Antitumor Activity

Chirality

Jan 2013

journal-article

Total Synthesis of Entecavir

Journal of Organic Chemistry

Jan 2013

journal-article

NH2 As a Directing Group: From the Cyclopalladation of Amino Esters to the Preparation of Benzolactams by Palladium(II)-Catalyzed Carbonylation of N-Unprotected Arylethylamines

Organometallics

Jan 2013

journal-article

Total Synthesis of (-)-Isoavenaciolide

Journal of Organic Chemistry

Jan 2013

journal-article

Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug. (-)-C75 has antitumor activity

Febs Journal

Jan 2012

journal-article

Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines

Chemical Communications

Jan 2011

journal-article

A new synthetic approach to the lactol moiety of halichoblelide

Tetrahedron

Jan 2011

journal-article

Stereoselective Acetate Aldol Reactions from Metal Enolates

Synthesis-Stuttgart

Jan 2011

journal-article

Regio- and stereoselective microwave-assisted synthesis of 5-alkyl-4-alkenyl-4-phenyl-1,3-oxazolidin-2-ones

Tetrahedron Letters

Jan 2010

journal-article

Preparation of alpha-labeled aldehydes by base-catalyzed exchange reactions

Journal of Labelled Compounds & Radiopharmaceuticals

Jan 2010

journal-article

Stereodivergent Addition of 4-Silyloxy-1,2-Allenes to Aldehydes by Hydroboration

Chemistry-a European Journal

Jan 2010

journal-article

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

Biochemical Pharmacology

Jan 2009

journal-article

Stereocontrolled Synthesis of Highly Functionalized Quaternary Carbon Centers: A Route to alpha-Substituted Serines

Angewandte Chemie-International Edition

Jan 2009

journal-article

Stereoselective Synthesis of (-)-Spicigerolide

Journal of Organic Chemistry

Jan 2009

journal-article

A stereoselective approach to 1,3-amino alcohols protected as cyclic carbamates: Kinetic vs. thermodynamic control

European Journal of Organic Chemistry

Jan 2007

journal-article

1-Phenylprop-2-ynyl acetate: A useful building block for the stereoselective construction of polyhydroxylated chains

Organic Letters

Jan 2006

journal-article

A versatile stereoselective approach to paraconic acids

Heterocycles

Jan 2006

journal-article

New stereoselective approach to 1,2,3-triols: Application to a straightforward access to polyoxamic acid array

Synlett

Jan 2006

journal-article

3,3 -Sigmatropic rearrangements in the enantioselective synthesis of (-)-methylenolactocin

Synthesis-Stuttgart

Jan 2004

journal-article

A straightforward synthesis of (-)-phaseolinic acid

Journal of Organic Chemistry

Jan 2004

journal-article

An efficient, stereoselective approach to syn-1,2-diols protected as cyclic carbonates

Journal of Organic Chemistry

Jan 2004

journal-article

Highly stereoselective approach to alk-2-yne-1,4-diols by oxazaborolidine-mediated reduction of alk-2-yne-1,4-diones

Journal of Organic Chemistry

Jan 2004

journal-article

Stereoselective synthesis of musclides A1, A2 and B

Tetrahedron-Asymmetry

Jan 2003

journal-article

Stereodivergent approach to beta-hydroxy alpha-amino acids from C-2-symmetrical alk-2-yne-1,4-diols

Organic Letters

Jan 2002

journal-article

Stereoselective approach to alk-2-yne-1,4-diols. Application to the synthesis of musclide B

Tetrahedron Letters

Jan 2002

journal-article

A concise synthesis of (-)-methylenolactocin and (-)- phaseolinic acid from (6S,9S)-tetradec-7-yne-6,9-diol

Synlett

Jan 2001

journal-article

A synthetic approach to 3-hydroxy 4-substituted carboxylic acids based on the stereoselective reduction of 1-trimethyisilyl-1-alkyn-3-ones

Tetrahedron

Jan 2000

journal-article

A synthesis of petrofuran based on the enantioselective reduction of 1-trimethylsilyl-4-alken-1-yn-3-ones

Synlett

Jan 1999

journal-article

A versatile approach to N-Boc-statine and N-Boc-norstatine based on the reduction of 1-trialkylsilyl acetylenic ketones. Strong remote effect of the C(1) substituent on the stereoselectivity

Organic Letters

Jan 1999

journal-article

Enantioselective synthesis of (3R,4E)-19-methylicos-4-en-1-yn-3-ol, a bioactive metabolite of the marine sponge Cribrochalina vasculum

Tetrahedron-Asymmetry

Jan 1999

journal-article

Enantioselective synthesis of alpha-hydroxy thioesters via oxazaborolidine-mediated reduction of alpha-phenylthio enones

Tetrahedron Letters

Jan 1998

journal-article

Oxazaborolidine-catalysed reduction of alk-2-ene-1,4diones. A convenient access to chiral 1,4-diols

Tetrahedron

Jan 1998

journal-article

Stereoselective reduction of alpha '-branched alpha,beta-ynones. Application to the synthesis of the Octalactin A ring

Tetrahedron Letters

Jan 1998

journal-article

Syntheses of the C-1 alkyl side chains of Zaragozic acids A and C

Tetrahedron Letters

Jan 1998

journal-article

Stereoselective reduction of unsaturated 1,4-diketones. A practical route to chiral 1,4-diols

Tetrahedron Letters

Jan 1997

journal-article

Highly enantioenriched propargylic alcohols by oxazaborolidine-mediated reduction of acetylenic ketones

Journal of Organic Chemistry

Jan 1996

journal-article

A SYNTHETIC APPROACH TOWARDS OCTALACTIN-A, BASED ON THE STEREOSELECTIVE REDUCTION OF ALPHA,BETA-UNSATURATED KETONES

Tetrahedron Letters

Jan 1995

journal-article

ALLYLIC ALCOHOLS OF UNEXPECTED CONFIGURATION BY OXAZABOROLIDINE-CATALYZED REDUCTION OF ALPHA,BETA-UNSATURATED KETONES - AN EXPLANATION-BASED ON MO CALCULATIONS

Tetrahedron-Asymmetry

Jan 1995

journal-article

ENANTIOSELECTIVE REDUCTION OF KETONES CATALYZED BY 1,3,2-OXAZABOROLIDINES PREPARED FROM PHENYLGLYCINE

Tetrahedron-Asymmetry

Jan 1994

journal-article

ENANTIOSELECTIVE REDUCTION OF ACETOPHENONE WITH 1,3,2-OXAZABOROLIDINES DERIVED FROM EPHEDRINE, PSEUDOEPHEDRINE, AND PHENYLGLYCINE

Tetrahedron-Asymmetry

Jan 1993

journal-article

GEM-DIFLUORINATION VERSUS 1,2-MIGRATION AND FRAGMENTATION IN THE REACTION OF 2-ULOSES AND 3-ULOSES WITH DAST - INFLUENCE OF STEREOCHEMISTRY AT THE ANOMERIC CARBON-ATOM

Journal of Organic Chemistry

Jan 1991

journal-article

IMPROVED METHODS FOR THE N-NITRATION OF AMIDES

Journal of Organic Chemistry

Jan 1991

journal-article

CONVERSION OF AMIDES TO S-ALKYL AND S-ARYL THIOESTERS VIA NITROSOAMIDES AND NITROAMIDES

Synthesis-Stuttgart

Jan 1989

journal-article

FLUOROAZOLES - AN MNDO SCF-MO STUDY

Heterocycles

Jan 1988

journal-article

FROM AZIDO ACIDS TO MACROLACTAMS AND MACROLACTONES

Journal of the Chemical Society-Chemical Communications

Jan 1988

journal-article

ASYMMETRIC ADDITION OF (E)-CROTYL-TRANS-2,5-DIMETHYLBOROLANES AND (Z)-CROTYL-TRANS-2,5-DIMETHYLBOROLANES TO ALDEHYDES

Journal of Organic Chemistry

Jan 1987

journal-article

NEW SYNTHETIC TRICKS - FROM ALIPHATIC-AMINES AND AMIDES TO AZIDES AND OR HOW TO CONVERT RNHCOR' INTO RNHCOR'' AVOIDING DRASTIC HYDROLYZES

Tetrahedron Letters

Jan 1987

journal-article

CHIRAL SYNTHONS FOR THE TOTAL SYNTHESIS OF FLUORO AMINO-ACIDS AND FLUORO ANALOGS OF ANTIBIOTIC SUGARS

Journal of Organic Chemistry

Jan 1986

journal-article

NEW SYNTHETIC TRICKS - ONE-POT PREPARATION OF N-SUBSTITUTED PHTHALIMIDES FROM AZIDES AND PHTHALIC-ANHYDRIDE

Tetrahedron Letters

Jan 1986

journal-article

NEW SYNTHETIC TRICKS - TRIPHENYLPHOSPHINE-MEDIATED AMIDE FORMATION FROM CARBOXYLIC-ACIDS AND AZIDES

Tetrahedron Letters

Jan 1984

journal-article

NITROSATION OF PEPTIDE-BONDS - CLEAVAGE OF NITROSATED PEPTIDES BY PYRROLIDINE AND ALPHA-AMINO ESTERS

Tetrahedron

Jan 1984

journal-article

REACTION OF N-NITROSO-N-ALKYLAMIDES AND N-NITRO-N-ALKYLAMIDES WITH AMINES

Journal of Organic Chemistry

Jan 1984

journal-article

NEW SYNTHETIC TRICKS USING OLD REAGENTS - A MILD METHOD FOR THE CONVERSION OF RCONHR TO RCONHR

Tetrahedron Letters

Jan 1982

journal-article

Jordi Garcia Gomez

Publications

New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells

New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells

Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells

Degradation of Fatty Acid Phase-Change Materials (PCM): New Approach for Its Characterization

Degradation of Fatty Acid Phase-Change Materials (PCM): New Approach for Its Characterization

Pyridine- and Quinoline-Derived Imines as N,N-Bidentate Directing Groups in Palladium versus Platinum C–H Bond Activation Reactions

A New Nanomedicine Platform to Deliver a Carnitine Palmitoyl-Transferase 1 (CPT1) Inhibitor into Glioma Cells and Neurons

An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (S)-5-(tert-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid

An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (S)-5-(tert-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid

An Overview of Nanomedicines for Neuron Targeting

Access to indolines from primary phenylethylamines by an unexpected palladium-catalyzed C–H functionalization process

Designed asymmetric coordination helicates with bis-β-diketonate ligands

Preparation of Substituted Tetrahydroisoquinolines by Pd(II)-Catalyzed NH2-Directed Insertion of Michael Acceptors into C-H Bonds Followed by NH2-Conjugated Addition

(−)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

Preparation of Substituted Tetrahydroisoquinolines by Pd(II)-Catalyzed NH2-Directed Insertion of Michael Acceptors into C–H Bonds Followed by NH2-Conjugated Addition

A Useful Allene for the Stereoselective Synthesis of Protected Quaternary 2-Amino-2-vinyl-1,3-diols

A Useful Allene for the Stereoselective Synthesis of Protected Quaternary 2-Amino-2-vinyl-1,3-diols

Chiral Induction in Intramolecular Rhodium-Catalyzed [2 + 2 + 2] Cycloadditions of Optically Active Allene–ene/yne–allene Substrates

Chiral Induction in Intramolecular Rhodium-Catalyzed 2+2+2 Cycloadditions of Optically Active Allene-ene/yne-allene Substrates

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+breast cancer

Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism

Multisensitive drug-loaded polyurethane/polyurea nanocapsules with pH-synchronized shell cationization and redox-triggered release

Multisensitive drug-loaded polyurethane/polyurea nanocapsules with pH-synchronized shell cationization and redox-triggered release

Molecular interplay between cancer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

Peptide-based chelating drugs in diagnosis and treatment of Alzheimer disease

Catalytic C H Activation of Phenylethylamines or Benzylamines and Their Annulation with Allenes

Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

Effect of carnitine palmitoyltransferase (CPT) 1A activity regulation on the control of the food intake

Convenient synthesis of C75, an inhibitor of FAS and CPT1

Differential Pharmacologic Properties of the Two C75 Enantiomers: (+)-C75 Is a Strong Anorectic Drug; (-)-C75 Has Antitumor Activity

Total Synthesis of Entecavir

NH2 As a Directing Group: From the Cyclopalladation of Amino Esters to the Preparation of Benzolactams by Palladium(II)-Catalyzed Carbonylation of N-Unprotected Arylethylamines

Total Synthesis of (-)-Isoavenaciolide

Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug. (-)-C75 has antitumor activity

Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines

A new synthetic approach to the lactol moiety of halichoblelide

Stereoselective Acetate Aldol Reactions from Metal Enolates

Regio- and stereoselective microwave-assisted synthesis of 5-alkyl-4-alkenyl-4-phenyl-1,3-oxazolidin-2-ones

Preparation of alpha-labeled aldehydes by base-catalyzed exchange reactions

Stereodivergent Addition of 4-Silyloxy-1,2-Allenes to Aldehydes by Hydroboration

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

Stereocontrolled Synthesis of Highly Functionalized Quaternary Carbon Centers: A Route to alpha-Substituted Serines

Stereoselective Synthesis of (-)-Spicigerolide

A stereoselective approach to 1,3-amino alcohols protected as cyclic carbamates: Kinetic vs. thermodynamic control

1-Phenylprop-2-ynyl acetate: A useful building block for the stereoselective construction of polyhydroxylated chains

A versatile stereoselective approach to paraconic acids

New stereoselective approach to 1,2,3-triols: Application to a straightforward access to polyoxamic acid array

3,3 -Sigmatropic rearrangements in the enantioselective synthesis of (-)-methylenolactocin

A straightforward synthesis of (-)-phaseolinic acid

An efficient, stereoselective approach to syn-1,2-diols protected as cyclic carbonates

Highly stereoselective approach to alk-2-yne-1,4-diols by oxazaborolidine-mediated reduction of alk-2-yne-1,4-diones

Stereoselective synthesis of musclides A1, A2 and B

Stereodivergent approach to beta-hydroxy alpha-amino acids from C-2-symmetrical alk-2-yne-1,4-diols

Stereoselective approach to alk-2-yne-1,4-diols. Application to the synthesis of musclide B

A concise synthesis of (-)-methylenolactocin and (-)- phaseolinic acid from (6S,9S)-tetradec-7-yne-6,9-diol

A synthetic approach to 3-hydroxy 4-substituted carboxylic acids based on the stereoselective reduction of 1-trimethyisilyl-1-alkyn-3-ones

A synthesis of petrofuran based on the enantioselective reduction of 1-trimethylsilyl-4-alken-1-yn-3-ones

A versatile approach to N-Boc-statine and N-Boc-norstatine based on the reduction of 1-trialkylsilyl acetylenic ketones. Strong remote effect of the C(1) substituent on the stereoselectivity

Enantioselective synthesis of (3R,4E)-19-methylicos-4-en-1-yn-3-ol, a bioactive metabolite of the marine sponge Cribrochalina vasculum

Enantioselective synthesis of alpha-hydroxy thioesters via oxazaborolidine-mediated reduction of alpha-phenylthio enones

Oxazaborolidine-catalysed reduction of alk-2-ene-1,4diones. A convenient access to chiral 1,4-diols

Stereoselective reduction of alpha '-branched alpha,beta-ynones. Application to the synthesis of the Octalactin A ring

Syntheses of the C-1 alkyl side chains of Zaragozic acids A and C

Stereoselective reduction of unsaturated 1,4-diketones. A practical route to chiral 1,4-diols

Highly enantioenriched propargylic alcohols by oxazaborolidine-mediated reduction of acetylenic ketones

A SYNTHETIC APPROACH TOWARDS OCTALACTIN-A, BASED ON THE STEREOSELECTIVE REDUCTION OF ALPHA,BETA-UNSATURATED KETONES

ALLYLIC ALCOHOLS OF UNEXPECTED CONFIGURATION BY OXAZABOROLIDINE-CATALYZED REDUCTION OF ALPHA,BETA-UNSATURATED KETONES - AN EXPLANATION-BASED ON MO CALCULATIONS

ENANTIOSELECTIVE REDUCTION OF KETONES CATALYZED BY 1,3,2-OXAZABOROLIDINES PREPARED FROM PHENYLGLYCINE

ENANTIOSELECTIVE REDUCTION OF ACETOPHENONE WITH 1,3,2-OXAZABOROLIDINES DERIVED FROM EPHEDRINE, PSEUDOEPHEDRINE, AND PHENYLGLYCINE

GEM-DIFLUORINATION VERSUS 1,2-MIGRATION AND FRAGMENTATION IN THE REACTION OF 2-ULOSES AND 3-ULOSES WITH DAST - INFLUENCE OF STEREOCHEMISTRY AT THE ANOMERIC CARBON-ATOM

IMPROVED METHODS FOR THE N-NITRATION OF AMIDES

CONVERSION OF AMIDES TO S-ALKYL AND S-ARYL THIOESTERS VIA NITROSOAMIDES AND NITROAMIDES

FLUOROAZOLES - AN MNDO SCF-MO STUDY

FROM AZIDO ACIDS TO MACROLACTAMS AND MACROLACTONES

ASYMMETRIC ADDITION OF (E)-CROTYL-TRANS-2,5-DIMETHYLBOROLANES AND (Z)-CROTYL-TRANS-2,5-DIMETHYLBOROLANES TO ALDEHYDES

NEW SYNTHETIC TRICKS - FROM ALIPHATIC-AMINES AND AMIDES TO AZIDES AND OR HOW TO CONVERT RNHCOR' INTO RNHCOR'' AVOIDING DRASTIC HYDROLYZES