Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease
Published by
Diabetologia
Summary
journal-article
About
My research interests are focused on examining the role of neurovascular unit in the retinal homeostasis and how diabetes induced dysfunction of neurovascular unit leads to the pathogenesis of Diabetic Retinopathy. In addition, I am also involved in pre-clinical evaluation of novel drugs and oligonucleotide therapeutics for the treatment of retinal neurodegeneration, inflammation and vascular dysfunction using both in vivo and in vitro models. My current postdoctoral research explores the role of lipoxidation in the diabetic retina with special focus on neurodegeneration and vascular dysfunction. I am also investigating novel treatments for Diabetic retinopathy by gene therapy and novel compounds using in vivo and in vitro functional techniques. During my PhD, I investigated the role of Interleukin-33 (IL-33) and inflammation in Müller cells, and the role it plays in the pathogenesis of retinal degenerative diseases using in vivo models and in vitro models. My PhD titled "The Role of Interleukin-33 in retinal degenerative diseases" was submitted in 2019. Prior to my PhD, I completed a MSc in Biomedical Science from Ulster University, UK with an integrated work experience as a Research Scholar in Eugene and Marilyn Glick Eye Institute, Indiana, USA. I am also a member of the Association for Research in Vision and Ophthalmology (ARVO) since 2017.
Work
Queen's University Belfast
United Kingdom of Great Britain and Northern Ireland
Queen's University Belfast
|Research Fellow
United Kingdom of Great Britain and Northern Ireland
→
Education
Queen's University Belfast
United Kingdom of Great Britain and Northern Ireland
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Publications
Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease
Published by
Diabetologia
Summary
journal-article
Protocol for single-molecule FISH in the developing mouse retinal vasculature
Published by
STAR Protocols
Summary
journal-article
Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2+/− rat model
Published by
Journal of Neuroinflammation
Summary
journal-article
Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model
Published by
Journal of Neuroinflammation
Summary
journal-article
ALDH1A1 gene therapy attenuates acrolein-induced Müller cell dysfunction in diabetic retinopathy
Published by
Investigative Opthalmology and Visual Science
Summary
other
IL-33 regulates Müller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy
Published by
Disease Models & Mechanisms
Summary
journal-article
IL-33 regulates Müller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy
Published by
Disease Models and Mechanisms
Summary
journal-article
IL-33 regulates Muller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy
Published by
Disease Models & Mechanisms
Summary
journal-article
Aldehyde Dehydrogenase and Aldo-Keto Reductase Enzymes: Basic Concepts and Emerging Roles in Diabetic Retinopathy
Published by
Antioxidants
Summary
journal-article
Aldehyde Dehydrogenase and Aldo-Keto Reductase Enzymes: Basic Concepts and Emerging Roles in Diabetic Retinopathy
Published by
Antioxidants
Summary
journal-article
Aldehyde dehydrogenase and aldo-keto reductase enzymes: basic concepts and emerging roles in diabetic retinopathy
Published by
Antioxidants
Summary
journal-article
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
Published by
JCI Insight
Summary
journal-article
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
Published by
JCI insight
Summary
journal-article
Gene therapeutic enhancement of acrolein detoxification mechanisms for the treatment of diabetic retinopathy (DR)
Published by
European Journal of Ophthalmology
Summary
other
Targeting TRP channels for the restoration of microvascular barrier function in diabetic macular oedema
Published by
Diabetic Medicine
Summary
other
Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway
Published by
Biomedicines
Summary
journal-article
Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway
Published by
Biomedicines
Summary
journal-article
Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway
Published by
Biomedicines
Summary
journal-article
The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy
Published by
Frontiers in Endocrinology
Summary
journal-article
The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy
Published by
Frontiers in Endocrinology
Summary
journal-article
VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions
Published by
Investigative ophthalmology & visual science
Summary
journal-article
VEGF-B Is an Autocrine Gliotrophic Factor for Muller Cells under Pathologic Conditions
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article
Ion channels and myogenic activity in retinal arterioles
Published by
Current Topics in Membranes
Summary
journal-article
Ion channels and myogenic activity in retinal arterioles
Published by
Current Topics in Membranes
Summary
book-chapter
Ion channels and myogenic activity in retinal arterioles
Published by
Current Topics in Membranes
Summary
journal-article
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
Published by
Journal of Neuroinflammation
Summary
journal-article
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
Published by
Journal of Neuroinflammation
Summary
journal-article
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
Published by
Journal of Neuroinflammation
Summary
journal-article
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7
Published by
International journal of molecular sciences
Summary
journal-article
Attenuating diabetic vascular and neuronal defects by targeting P2rx7
Published by
International Journal of Molecular Sciences
Summary
journal-article
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7
Published by
International Journal of Molecular Sciences
Summary
journal-article
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7
Published by
International Journal of Molecular Sciences
Summary
journal-article
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7
Published by
International Journal of Molecular Sciences
Summary
journal-article
SIGIRR deficiency accelerates diabetes-induced retinal neurodegeneration
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article
VEGF-B protects Muller cells from hypoxic- and oxidative stress-mediated damage
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article
Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
Published by
Diabetologia
Summary
journal-article
Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
Published by
Diabetologia
Summary
journal-article
Muller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
Published by
Diabetologia
Summary
journal-article
Cytokine Signaling Protein 3 (SOCS3) deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis
Published by
The American Journal of Pathology
Summary
journal-article
Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis
Published by
American Journal of Pathology
Summary
journal-article
Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis
Published by
The American Journal of Pathology
Summary
journal-article
Characterization of a spontaneously immortalized murine Müller glial cell line QMMuC-1
Published by
Investigative Opthalmology and Visual Science
Summary
journal-article
Characterization of a spontaneously immortalized murine müller glial cell line QMMuC-1
Published by
Investigative Ophthalmology and Visual Science
Summary
journal-article
Characterization of a Spontaneously Immortalized Murine Muller Glial Cell Line QMMuC-1
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article
Increased diabetic retinal neuronal degeneration in IL-33(-/-) mice is related to reduced Muller cell-derived neurotrophic factors
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article
Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article
Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina
Published by
Investigative ophthalmology & visual science
Summary
journal-article
Diabetes impairs the aldehyde detoxifying capacity of the retina
Published by
Investigative Ophthalmology and Visual Science
Summary
journal-article
Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article
Deletion of interleukin-33 (IL33) results in persistent Muller cell activation during retinal detachment
Published by
Investigative Ophthalmology & Visual Science
Summary
journal-article