Kim Kampen

About

Kim Kampen is an assistant professor and group leader at the Department of Radiotherapy. During her Ph.D. (2013-2015), Kim worked with Prof. de Bont (University of Groningen) on the role of vascular endothelial growth factors in pediatric acute myeloid leukemia. From June 2015 onwards, she performed postdoctoral research at the Catholic University (KU Leuven, Belgium) with Prof. Kim De Keersmaecker, studying the role of ribosomal gene defects in cancer. She identified the so called “oncoribosomes”, mutant ribosomes that have specific advantageous translational capacities in T-cell leukemia. She received several awards and grants to support and establish her lab, including the KWF Young Investigator Grant 2021, the KNAW early career award 2021, and the FEBS excellence award 2021. Her research is focused on the identification of new molecular mechanisms of serine/glycine synthesis upregulation in cancer, which allows building a patient stratification framework for cancers that can benefit from serine synthesis inhibiting compounds. She repurposed sertraline as (neo)adjuvant therapeutic approach for serine/glycine dependent and/or radioresistant cancers. Besides targeting the cancer cells, sertraline normalizes the immune landscape of tumors by targeting the immune checkpoint galectin-1.

Publications

Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling

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The discovery and early understanding of leukemia

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The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

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EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion

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Identification of new possible targets for leukemia treatment by kinase activity profiling

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Impaired Long-Term Expansion and Self-Renewal Potential of Pediatric Acute Myeloid Leukemia Initiating Cells by PTK787/ZK 222584

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Membrane Proteins: The Key Players of a Cancer Cell

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The DMT1 isoform lacking the iron‐response element regulates normal and malignant hematopoiesis viaNOTCH pathway activation

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FEBS Letters

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Patient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivity.

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Neuro-oncology advances

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Data from Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth

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preprint

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer.

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British journal of cancer

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Iron‐responsive element of Divalent metal transporter 1 (Dmt1) controls Notch‐mediated cell fates

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The FEBS Journal

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Drivers of de novo Serine/Glycine synthesis in acute leukemia

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FEBS Letters

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Data from Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth

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preprint

Linking Serine/Glycine Metabolism to Radiotherapy Resistance

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Cancers

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Linking Serine/Glycine Metabolism to Radiotherapy Resistance

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Cancers

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The ins and outs of serine and glycine metabolism in cancer

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Nature Metabolism

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Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth

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Molecular Cancer Therapeutics

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Hallmarks of ribosomopathies

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Nucleic Acids Research

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Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

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Nature Communications

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Rise of the specialized onco-ribosomes

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Oncotarget

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VEGFC antibody therapy drives differentiation of AML

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Cancer Research

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The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL

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Leukemia

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The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.

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Leukemia

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The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types.

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Oncotarget

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Signaling and molecular basis of bone marrow niche angiogenesis in leukemia.

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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

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Cancer cell

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Can kinomics and proteomics bridge the gap between pediatric cancers and newly designed kinase inhibitors?

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Cell. Mol. Life Sci.

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Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia

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Oncotarget

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EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System.

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Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia.

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Oncotarget

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Acute myeloid leukemia in the vascular niche.

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Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma

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PLoS ONE

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LOW GRADE GLIOMAS.

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Neuro-oncology

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Abstract B4: Growth-factor-driven rescue to receptor tyrosine kinase inhibitors in pediatric low-grade astrocytoma and ependymoma

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Cancer Res

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Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.

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Abstract 5085: Less tumor engraftment after anti-VEGF therapy in pediatric low grade astrocytoma.

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Cancer Res

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Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.

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Molecular cancer research : MCR

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Abstract 2772: Inhibition of EGFR activity reduces AML cell survival via inhibition of downstream Akt and Erk signaling pathways.

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Cancer Res

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The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

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Anti-Cancer Drugs

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journal-article

EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion.

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Neuro-oncology

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Vascular endothelial growth factor signaling in acute myeloid leukemia

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Vascular Endothelial Growth Factor A isoform mRNA expression in pediatric acute myeloid leukemia.

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Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling.

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journal-article

Kim Kampen