Kim Kampen

About

Kim Kampen is an assistant professor and group leader at the Department of Radiotherapy. During her Ph.D. (2013-2015), Kim worked with Prof. de Bont (University of Groningen) on the role of vascular endothelial growth factors in pediatric acute myeloid leukemia. From June 2015 onwards, she performed postdoctoral research at the Catholic University (KU Leuven, Belgium) with Prof. Kim De Keersmaecker, studying the role of ribosomal gene defects in cancer. She identified the so called “oncoribosomes”, mutant ribosomes that have specific advantageous translational capacities in T-cell leukemia. She received several awards and grants to support and establish her lab, including the KWF Young Investigator Grant 2021, the KNAW early career award 2021, and the FEBS excellence award 2021. Her research is focused on the identification of new molecular mechanisms of serine/glycine synthesis upregulation in cancer, which allows building a patient stratification framework for cancers that can benefit from serine synthesis inhibiting compounds. She repurposed sertraline as (neo)adjuvant therapeutic approach for serine/glycine dependent and/or radioresistant cancers. Besides targeting the cancer cells, sertraline normalizes the immune landscape of tumors by targeting the immune checkpoint galectin-1.

Publications

Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling

journal-article

The discovery and early understanding of leukemia

journal-article

The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

journal-article

EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion

journal-article

Identification of new possible targets for leukemia treatment by kinase activity profiling

journal-article

Impaired Long-Term Expansion and Self-Renewal Potential of Pediatric Acute Myeloid Leukemia Initiating Cells by PTK787/ZK 222584

journal-article

Membrane Proteins: The Key Players of a Cancer Cell

journal-article

The DMT1 isoform lacking the iron‐response element regulates normal and malignant hematopoiesis viaNOTCH pathway activation

FEBS Letters

journal-article

Patient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivity.

Neuro-oncology advances

journal-article

Data from Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth

preprint

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer.

British journal of cancer

journal-article

Iron‐responsive element of Divalent metal transporter 1 (Dmt1) controls Notch‐mediated cell fates

The FEBS Journal

journal-article

Drivers of de novo Serine/Glycine synthesis in acute leukemia

FEBS Letters

journal-article

Data from Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth

preprint

Linking Serine/Glycine Metabolism to Radiotherapy Resistance

Cancers

journal-article

Linking Serine/Glycine Metabolism to Radiotherapy Resistance

Cancers

journal-article

The ins and outs of serine and glycine metabolism in cancer

Nature Metabolism

journal-article

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth

Molecular Cancer Therapeutics

journal-article

Hallmarks of ribosomopathies

Nucleic Acids Research

journal-article

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

Nature Communications

journal-article

Rise of the specialized onco-ribosomes

Oncotarget

journal-article

VEGFC antibody therapy drives differentiation of AML

Cancer Research

journal-article

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL

Leukemia

journal-article

The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.

Leukemia

journal-article

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types.

Oncotarget

journal-article

Signaling and molecular basis of bone marrow niche angiogenesis in leukemia.

journal-article

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

Cancer cell

journal-article

Can kinomics and proteomics bridge the gap between pediatric cancers and newly designed kinase inhibitors?

Cell. Mol. Life Sci.

journal-article

Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia

Oncotarget

journal-article

EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System.

journal-article

Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia.

Oncotarget

journal-article

Acute myeloid leukemia in the vascular niche.

journal-article

Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma

PLoS ONE

journal-article

LOW GRADE GLIOMAS.

Neuro-oncology

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Abstract B4: Growth-factor-driven rescue to receptor tyrosine kinase inhibitors in pediatric low-grade astrocytoma and ependymoma

Cancer Res

journal-article

Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.

journal-article

Abstract 5085: Less tumor engraftment after anti-VEGF therapy in pediatric low grade astrocytoma.

Cancer Res

journal-article

Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.

Molecular cancer research : MCR

journal-article

Abstract 2772: Inhibition of EGFR activity reduces AML cell survival via inhibition of downstream Akt and Erk signaling pathways.

Cancer Res

journal-article

The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

Anti-Cancer Drugs

journal-article

EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion.

Neuro-oncology

journal-article

Vascular endothelial growth factor signaling in acute myeloid leukemia

journal-article

Vascular Endothelial Growth Factor A isoform mRNA expression in pediatric acute myeloid leukemia.

journal-article

Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling.

journal-article