Martin Taylor

Work

The University of Edinburgh
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Professor

United Kingdom of Great Britain and Northern Ireland

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European Bioinformatics Institute
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Senior Research Associate

United Kingdom of Great Britain and Northern Ireland

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University of Oxford
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Research Associate

United Kingdom of Great Britain and Northern Ireland

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Education

University of Edinburgh
United Kingdom of Great Britain and Northern Ireland

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Ph.D.

University of Liverpool
United Kingdom of Great Britain and Northern Ireland

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B.Sc.

Publications

Genetic background sets the trajectory of cancer evolution

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other

Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis

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preprint

Genetic background sets the trajectory of cancer evolution

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preprint

Strand-resolved mutagenicity of DNA damage and repair

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Nature

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journal-article

Single-mitosis dissection of acute and chronic DNA mutagenesis and repair

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Nature Genetics

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journal-article

DNA lesion bypass and the stochastic dynamics of transcription-coupled repair

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Proceedings of the National Academy of Sciences

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journal-article

The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation

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Genome Biology

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journal-article

In vivo modeling of patient genetic heterogeneity identifies new ways to target cholangiocarcinoma

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Cancer Research

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journal-article

Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

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Nature

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journal-article

Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome

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Genome Research

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journal-article

Detecting oncogenic selection through biased allele retention in The Cancer Genome Atlas

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preprint

Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum

Published by

Genes & Development

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journal-article

Evolutionary dependencies show paths to cancer development

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Nature Genetics

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journal-article

Functional annotation of human long noncoding RNAs via molecular phenotyping

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Genome Research

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journal-article

Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum

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Genes & Development

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journal-article

Pervasive lesion segregation shapes cancer genome evolution

Published by

Nature

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journal-article

Identification of a Nonsense-Mediated Decay pathway at the Endoplasmic Reticulum

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preprint

Comparative transcriptomics of primary cells in vertebrates

Published by

Genome Research

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journal-article

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

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PLOS Genetics

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journal-article

Manipulation of Dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.

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Disease models & mechanisms

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journal-article

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.

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Nucleic acids research

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journal-article

Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers.

Published by

Genome biology

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journal-article

Bidirectional transcription marks accessible chromatin and is not specific to enhancers

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preprint

Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types

Published by

PLOS Genetics

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journal-article

Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq.

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journal-article

Lagging-strand replication shapes the mutational landscape of the genome.

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journal-article

Exome Sequencing to Detect Rare Variants Associated With General Cognitive Ability: A Pilot Study.

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journal-article

The frequent evolutionary birth and death of functional promoters in mouse and human.

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journal-article

Homozygous loss-of-function variants in European cosmopolitan and isolate populations.

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journal-article

FRA2A is a CGG repeat expansion associated with silencing of AFF3.

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journal-article

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.

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journal-article

A CGG-Repeat Expansion Mutation in ZNF713 Causes FRA7A: Association with Autistic Spectrum Disorder in two Families.

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journal-article

Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism.

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journal-article

Quantification of epigenetic biomarkers: an evaluation of established and emerging methods for DNA methylation analysis.

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journal-article

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

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journal-article

Loss of ALDH18A1 function is associated with a cellular lipid droplet phenotype suggesting a link between autosomal recessive cutis laxa type 3A and Warburg Micro syndrome.

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journal-article

Variant detection sensitivity and biases in whole genome and exome sequencing.

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SuRFing the genomics wave: an R package for prioritising SNPs by functionality.

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Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

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journal-article

An atlas of active enhancers across human cell types and tissues.

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journal-article

A promoter-level mammalian expression atlas.

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journal-article

Application of next generation qPCR and sequencing platforms to mRNA biomarker analysis.

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journal-article

Quantifying single nucleotide variant detection sensitivity in exome sequencing.

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journal-article

Evolution of the human-specific microRNA miR-941.

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journal-article

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.

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journal-article

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

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journal-article

Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex

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journal-article

CEP152 is a genome maintenance protein disrupted in Seckel syndrome

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journal-article

The (non)malignancy of cancerous amino acidic substitutions

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journal-article

High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues

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journal-article

Dynamic and Physical Clustering of Gene Expression during Epidermal Barrier Formation in Differentiating Keratinocytes

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journal-article

MOLECULAR BIOLOGY The Structure of Change

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journal-article

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

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journal-article

Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii DNA in bronchoalveolar lavage fluid of HIV-infected patients (vol 63, pg 154, 2008)

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journal-article

Rapidly evolving human promoter regions

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journal-article

Singleton SNPs in the human genome and implications for genome-wide association studies

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journal-article

Expression of the fras1/frem Gene Family During Zebrafish Development and Fin Morphogenesis

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journal-article

Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii DNA in bronchoalveolar lavage fluid of HIV-infected patients

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journal-article

Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes: Authors' Reply.

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journal-article

Management, presentation and interpretation of genome scans using GSCANDB

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journal-article

Identification of common genetic variation that modulates alternative splicing

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journal-article

Genome-wide genetic association of complex traits in heterogeneous stock mice.

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journal-article

Genomic anatomy of the Tyrp1 (brown) deletion complex

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journal-article

Heterotachy in mammalian promoter evolution

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journal-article

Problems of developing molecular diagnostic tests for opportunistic pathogens: The example of Pneumocystis jirovecii

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conference-paper

A high-resolution single nucleotide polymorphism genetic map of the mouse genome.

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journal-article

Genome-wide analysis of mammalian promoter architecture and evolution

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journal-article

Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs

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journal-article

The transcriptional landscape of the mammalian genome

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journal-article

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

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journal-article

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

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Occurrence and consequences of coding sequence insertions and deletions in mammalian genomes

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journal-article

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis

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journal-article

Sequence characterization of teleost fish melanocortin receptors

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book-chapter

Sequence characterization of teleost fish melanocortin receptors.

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journal-article

Evolutionary constraints on the disrupted in schizophrenia locus

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journal-article

Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins

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journal-article

The structure and evolution of the melanocortin and MCH receptors in fish and mammals

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journal-article

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

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journal-article

Sushi gets serious: the draft genome sequence of the pufferfish Fugu rubripes.

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journal-article

The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectrics.

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journal-article

Functional characterisation of DISC1, a candidate susceptibility gene for major psychiatric illness

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conference-paper

More biology from the sequence.

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journal-article

Characterization and comparative analysis of the EGLN gene family

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journal-article

The meso-genomic era.

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journal-article

Genomic sequence allalysis of Fugu rubripes CFTR and flanking genes in a 60 kb region conserving synteny with 800 kb of human chromosome 7

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journal-article

Isolation and characterization of the mouse translin-associated protein X (Trax) gene

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journal-article

Characterisation of DISC-1: A gene disrupted by a translocation associated with schizophrenia.

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journal-article

Disruption of two novel genes by a translocation co-segregating with schizophrenia

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journal-article