Matthew Gentry

About

He began his independent career in 2008 and is now Chair of Biochemistry & Molecular Biology in the College of Medicine at University of Florida. Gentry is a prominent brain metabolism scientist who has made seminal discoveries in the realm of brain glycogen and glucose metabolism and how perturbations in these pathways impact neuro-centric diseases. Dr. Gentry has nearly 20 years of experience working on glycogen storage diseases (GSD). He did research on cell signaling and cell division at Syracuse University for his Ph.D in Molecular Biology (2003) and then worked on the GSD and childhood dementia called Lafora disease as a postdoctoral scholar in the laboratory of Jack Dixon at UC-San Diego where he defined the biochemical properties of the genes mutated in the disease. Building on this foundational biochemistry, he has been continuously funded by NIH since 2007 via a K99/R00, multiple R01 grants, and a recent R35 that focuses on Brain Glycogen – Metabolism, Mechanisms, and Therapeutic Potential. He has also been continuously funded by NSF since receiving a NSF CAREER award in 2013 to study the enzymology of metabolic enzymes. His lab now works on several GSDs and the role of glycogen in cancer, focusing on defining disease mechanisms, pre-clinical drugs and clinical biomarkers. Dr. Gentry was awarded the 2014 NIH IDeA Thomas Maciag Award and the 2018 NINDS Landis Award. He serves on multiple NIH, NSF, and foundation study sections. He is a Journal of Biological Chemistry Editorial Board member and a Council Member for the American Society of Biochemistry and Molecular Biology. He is also a science advisor for the Lafora disease patient advocacy group, Glut1 Deficiency Syndrome Foundation, and Adult Polyglucosan Body Disease Foundation in addition to several for-profit companies.

Work

University of Florida College of Medicine
|

Professor & Chair

US

→

University of Kentucky
|

Professor

US

→

Publications

https://pubmed.ncbi.nlm.nih.gov/37808860/

Summary

preprint

Neuromodulator control of energy reserves in dopaminergic neurons

Summary

preprint

The multifaceted roles of the brain glycogen

Published by

Journal of Neurochemistry

Summary

journal-article

Effect of intracerebroventricular administration of alglucosidase alfa in two mouse models of Lafora disease: Relevance for clinical practice

Published by

Epilepsy Research

Summary

journal-article

Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders

Published by

Science Translational Medicine

Summary

journal-article

Prognostic value of pathogenic variants in Lafora Disease: systematic review and meta-analysis of patient-level data.

Published by

Orphanet journal of rare diseases

Summary

journal-article

Prognostic value of pathogenic variants in Lafora Disease: systematic review and meta-analysis of patient-level data

Published by

Orphanet Journal of Rare Diseases

Summary

journal-article

The multifaceted roles of the brain glycogen.

Published by

Journal of neurochemistry

Summary

journal-article

The multifaceted roles of the brain glycogen

Published by

Journal of Neurochemistry

Summary

journal-article

Spatial Metabolome Lipidome and Glycome from a Single brain Section.

Published by

bioRxiv. 2023 Jul 25:2023.07.22.550155

Summary

preprint

Current avenues of gene therapy in Pompe disease.

Published by

Current opinion in neurology

Summary

journal-article

Current avenues of gene therapy in Pompe disease

Published by

Current Opinion in Neurology

Summary

journal-article

Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis.

Published by

Journal of neurochemistry

Summary

journal-article

Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis.

Published by

Nature communications

Summary

journal-article

Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis

Published by

Nature Communications

Summary

journal-article

<i>In situ</i> microwave fixation provides an instantaneous snapshot of the brain metabolome.

Published by

Cell reports methods

Summary

journal-article

In situ microwave fixation provides an instantaneous snapshot of the brain metabolome

Published by

Cell Reports Methods

Summary

journal-article

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence.

Published by

eLife

Summary

journal-article

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence

Published by

eLife

Summary

journal-article

Cervical spinal cord injury leads to injury and altered metabolism in the lungs.

Published by

Brain communications

Summary

journal-article

Cervical spinal cord injury leads to injury and altered metabolism in the lungs

Published by

Brain Communications

Summary

journal-article

MetaVision3D: Automated Framework for the Generation of Spatial Metabolome Atlas in 3D

Published by

bioRxiv

Summary

other

Prognostic value of pathogenic variants in Lafora Disease: systematic review and meta-analysis of patient-level data

Published by

Research Square

Summary

other

RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities

Published by

Heliyon

Summary

journal-article

Spatial Metabolome Lipidome and Glycome from a Single brain Section

Published by

bioRxiv

Summary

other

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

Published by

bioRxiv

Summary

other

Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer

Published by

Cell Death and Disease

Summary

journal-article

Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer.

Published by

Cell death & disease

Summary

journal-article

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

Published by

bioRxiv

Summary

preprint

RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities

Summary

online-resource

Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model.

Published by

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Summary

journal-article

Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model

Published by

Neurotherapeutics

Summary

journal-article

The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors.

Published by

The Journal of biological chemistry

Summary

journal-article

Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency.

Published by

Science translational medicine

Summary

journal-article

Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency

Published by

Science Translational Medicine

Summary

journal-article

Differential activity of glucan phosphatase starch EXcess4 orthologs from agronomic crops

Published by

Biocatalysis and Agricultural Biotechnology

Summary

journal-article

Differential activity of glucan phosphatase starch EXcess4 orthologs from agronomic crops

Published by

Biocatalysis and Agricultural Biotechnology

Summary

journal-article

In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues.

Published by

EMBO molecular medicine

Summary

journal-article

In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues

Published by

EMBO Molecular Medicine

Summary

journal-article

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer.

Published by

International journal of molecular sciences

Summary

journal-article

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer

Published by

International Journal of Molecular Sciences

Summary

journal-article

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer

Published by

International Journal of Molecular Sciences

Summary

journal-article

The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

Published by

Journal of Biological Chemistry

Summary

journal-article

Two Diseases—One Preclinical Treatment Targeting Glycogen Synthesis

Published by

Neurotherapeutics

Summary

journal-article

Two Diseases—One Preclinical Treatment Targeting Glycogen Synthesis

Published by

Neurotherapeutics

Summary

journal-article

Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer.

Published by

Cell death and differentiation

Summary

journal-article

Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer

Published by

Cell Death and Differentiation

Summary

journal-article

High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity.

Published by

Advances in cancer research

Summary

journal-article

High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity

Published by

Advances in Cancer Research

Summary

book-chapter

A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate

Published by

bioRxiv

Summary

other

In Situ Microwave Fixation to Define the Terminal Rodent Brain Metabolome

Published by

bioRxiv

Summary

other

Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor

Published by

Neuroscience Letters

Summary

journal-article

In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains

Published by

Alzheimer's and Dementia

Summary

journal-article

Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor.

Published by

Neuroscience letters

Summary

journal-article

Lactate supports a metabolic-epigenetic link in macrophage polarization.

Published by

Science advances

Summary

journal-article

Lactate supports a metabolic-epigenetic link in macrophage polarization

Published by

Science Advances

Summary

journal-article

Emerging roles of N-linked glycosylation in brain physiology and disorders.

Published by

Trends in endocrinology and metabolism: TEM

Summary

journal-article

Emerging roles of N-linked glycosylation in brain physiology and disorders

Published by

Trends in Endocrinology and Metabolism

Summary

journal-article

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease.

Published by

Cell death & disease

Summary

journal-article

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Published by

Cell Death and Disease

Summary

journal-article

An empirical pipeline for personalized diagnosis of Lafora disease mutations.

Published by

iScience

Summary

journal-article

An empirical pipeline for personalized diagnosis of Lafora disease mutations

Published by

iScience

Summary

journal-article

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.

Published by

Molecular neurodegeneration

Summary

journal-article

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

Published by

Molecular Neurodegeneration

Summary

journal-article

Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease.

Published by

Brain : a journal of neurology

Summary

journal-article

Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease

Published by

Brain

Summary

journal-article

The 6th International Lafora Epilepsy Workshop: Advances in the search for a cure

Published by

Epilepsy & Behavior

Summary

journal-article

The 6th International Lafora Epilepsy Workshop: Advances in the search for a cure

Published by

Epilepsy and Behavior

Summary

journal-article

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.

Published by

Cell metabolism

Summary

journal-article

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

Published by

Cell Metabolism

Summary

journal-article

Generation and characterization of a laforin nanobody inhibitor.

Published by

Clinical biochemistry

Summary

journal-article

Generation and characterization of a laforin nanobody inhibitor

Published by

Clinical Biochemistry

Summary

journal-article

Generation and characterization of a laforin nanobody inhibitor

Published by

Clinical Biochemistry

Summary

journal-article

Serotonergic therapy in epilepsy.

Published by

Current opinion in neurology

Summary

journal-article

Serotonergic therapy in epilepsy

Published by

Current Opinion in Neurology

Summary

journal-article

251st ENMC international workshop: Polyglucosan storage myopathies 13–15 December 2019, Hoofddorp, the Netherlands

Published by

Neuromuscular Disorders

Summary

conference-paper

An empirical pipeline for personalized diagnosis of Lafora disease mutations

Published by

bioRxiv

Summary

other

Generation and characterization of a laforin nanobody inhibitor

Published by

bioRxiv

Summary

other

Hippocampal Disruptions of Synaptic and Astrocyte Metabolism are Primary Events of Early Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease

Published by

SSRN

Summary

other

In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains.

Published by

Alzheimer's & dementia : the journal of the Alzheimer's Association

Summary

journal-article

Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides

Published by

Human Molecular Genetics

Summary

journal-article

Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging.

Published by

Journal of lipid research

Summary

journal-article

Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging

Published by

Journal of Lipid Research

Summary

journal-article

Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging

Published by

Journal of Lipid Research

Summary

journal-article

Polyglucosan body structure in Lafora disease.

Published by

Carbohydrate polymers

Summary

journal-article

Polyglucosan body structure in Lafora disease

Published by

Carbohydrate Polymers

Summary

journal-article

Polyglucosan body structure in Lafora disease

Published by

Carbohydrate Polymers

Summary

journal-article

Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides.

Published by

Human molecular genetics

Summary

journal-article

The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation.

Published by

Annals of translational medicine

Summary

journal-article

APOE alters glucose flux through central carbon pathways in astrocytes.

Published by

Neurobiology of disease

Summary

journal-article

APOE alters glucose flux through central carbon pathways in astrocytes

Published by

Neurobiology of Disease

Summary

journal-article

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.

Published by

Epilepsy & behavior : E&B

Summary

journal-article

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic

Published by

Epilepsy and Behavior

Summary

conference-paper

Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis.

Published by

Journal of clinical medicine

Summary

journal-article

Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis

Published by

Journal of Clinical Medicine

Summary

journal-article

Clear cell adenocarcinoma of the urinary bladder is a glycogen-rich tumor with poorer prognosis

Published by

Journal of Clinical Medicine

Summary

journal-article

APOΕ4 lowers energy expenditure and impairs glucose oxidation by increasing flux through aerobic glycolysis

Published by

bioRxiv

Summary

other

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

Published by

Carbohydrate Polymers

Summary

journal-article

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

Published by

Carbohydrate Polymers

Summary

journal-article

Antibody-Mediated Enzyme Therapeutics and Applications in Glycogen Storage Diseases

Published by

Trends in Molecular Medicine

Summary

journal-article

Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers

Published by

Cell Metabolism

Summary

journal-article

Central Nervous System Delivery and Biodistribution Analysis of an Antibody-Enzyme Fusion for the Treatment of Lafora Disease.

Published by

Molecular pharmaceutics

Summary

journal-article

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry.

Published by

Carbohydrate polymers

Summary

journal-article

Central Nervous System Delivery and Biodistribution Analysis of an Antibody-Enzyme Fusion for the Treatment of Lafora Disease

Published by

Molecular Pharmaceutics

Summary

journal-article

Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion.

Published by

Cell metabolism

Summary

journal-article

Antibody-Mediated Enzyme Therapeutics and Applications in Glycogen Storage Diseases

Published by

Trends in Molecular Medicine

Summary

journal-article

Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion

Published by

Cell Metabolism

Summary

journal-article

Clinical Features, Survival and Prognostic Factors of Glycogen-Rich Clear Cell Carcinoma (GRCC) of the Breast in the U.S. Population.

Published by

Journal of clinical medicine

Summary

journal-article

Clinical features, survival and prognostic factors of glycogen-rich clear cell carcinoma (GRCC) of the breast in the U.S. population

Published by

Journal of Clinical Medicine

Summary

journal-article

Clinical Features, Survival and Prognostic Factors of Glycogen-Rich Clear Cell Carcinoma (GRCC) of the Breast in the U.S. Population

Published by

Journal of Clinical Medicine

Summary

journal-article

Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future.

Published by

Advances in neurobiology

Summary

journal-article

Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future

Published by

Advances in Neurobiology

Summary

book-chapter

The 4th International Lafora Epilepsy Workshop: Shifting paradigms, paths to treatment, and hope for patients

Published by

Epilepsy & Behavior

Summary

journal-article

The 4th International Lafora Epilepsy Workshop: Shifting paradigms, paths to treatment, and hope for patients

Published by

Epilepsy and Behavior

Summary

conference-paper

Central nervous system delivery and biodistribution analysis of an antibody-enzyme fusion for the treatment of lafora disease

Published by

bioRxiv

Summary

other

Compartmentalized glycogenolysis regulates lung cancer transcription

Published by

bioRxiv

Summary

other

Rapid and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates using gas chromatography mass spectrometry

Published by

bioRxiv

Summary

other

Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion

Published by

bioRxiv

Summary

other

Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers.

Published by

Cell metabolism

Summary

journal-article

Oligomerization and carbohydrate binding of glucan phosphatases.

Published by

Analytical biochemistry

Summary

journal-article

Oligomerization and carbohydrate binding of glucan phosphatases

Published by

Analytical Biochemistry

Summary

journal-article

A novel EPM2A mutation yields a slow progression form of Lafora disease

Published by

Epilepsy Research

Summary

journal-article

A novel EPM2A mutation yields a slow progression form of Lafora disease

Published by

Epilepsy Research

Summary

journal-article

Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'-<i>O</i>-phosphotransferase type IIa.

Published by

MedChemComm

Summary

journal-article

Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3′-O-phosphotransferase type IIa

Published by

MedChemComm

Summary

journal-article

Lafora disease offers a unique window into neuronal glycogen metabolism

Published by

Journal of Biological Chemistry

Summary

journal-article

The 3rd International Lafora Epilepsy Workshop: Evidence for a cure

Published by

Epilepsy and Behavior

Summary

conference-paper

The UBA domain of SnRK1 promotes activation and maintains catalytic activity

Published by

Biochemical and Biophysical Research Communications

Summary

journal-article

The unique evolution of the carbohydrate-binding module CBM20 in laforin

Published by

FEBS Letters

Summary

journal-article

Oligomerization and carbohydrate binding of glucan phosphatases

Published by

Analytical Biochemistry

Summary

journal-article

What’s in a name?

Published by

eLife

Summary

journal-article

What’s in a name?

Published by

eLife

Summary

journal-article

Reexamining Chronic Toxoplasma gondii Infection: Surprising Activity for a “Dormant” Parasite

Published by

Current Clinical Microbiology Reports

Summary

journal-article

Structural biology of glucan phosphatases from humans to plants

Published by

Current Opinion in Structural Biology

Summary

journal-article

Structural biology of glucan phosphatases from humans to plants

Published by

Current Opinion in Structural Biology

Summary

journal-article

Assessing the biological activity of the glucan phosphatase laforin

Published by

Methods in Molecular Biology

Summary

book-chapter

Plant α-glucan phosphatases SEX4 and LSF2 display different affinity for amylopectin and amylose

Published by

FEBS Letters

Summary

journal-article

Structural mechanisms of plant glucan phosphatases in starch metabolism

Published by

FEBS Journal

Summary

journal-article

Unique carbohydrate binding platforms employed by the glucan phosphatases

Published by

Cellular and Molecular Life Sciences

Summary

journal-article

Mechanistic insights into glucan phosphatase activity against polyglucan substrates

Published by

Journal of Biological Chemistry

Summary

journal-article

Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease

Published by

Molecular Cell

Summary

journal-article

Phosphoglucan-bound structure of starch phosphatase Starch Excess4 reveals the mechanism for C6 specificity

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Expression, purification and characterization of soluble red rooster laforin as a fusion protein in Escherichia coli

Published by

BMC Biochemistry

Summary

journal-article

HUWE1 Is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold

Published by

Molecular and Cellular Biology

Summary

journal-article

A malachite green-based assay to assess glucan phosphatase activity

Published by

Analytical Biochemistry

Summary

journal-article

Dimerization of the Glucan Phosphatase Laforin Requires the Participation of Cysteine 329

Published by

PLoS ONE

Summary

journal-article

Laforin, a protein with many faces: Glucan phosphatase, adapter protein, et al.ii

Published by

FEBS Journal

Summary

journal-article

Structure of the Arabidopsis glucan phosphatase LIKE SEX FOUR2 reveals a unique mechanism for starch dephosphorylation

Published by

Plant Cell

Summary

journal-article

A bioassay for Lafora disease and laforin glucan phosphatase activity

Published by

Clinical Biochemistry

Summary

journal-article

Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity

Published by

Human Molecular Genetics

Summary

journal-article

Deciphering the role of malin in the lafora progressive myoclonus epilepsy

Published by

IUBMB Life

Summary

journal-article

Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level

Published by

BMC Evolutionary Biology

Summary

journal-article

Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity

Published by

PLoS ONE

Summary

journal-article

Laforin,,a dual-specificity phosphatase involved in Lafora disease,is phosphorylated at Ser <sup>25</sup> by AMP-activated protein kinase

Published by

Biochemical Journal

Summary

journal-article

The phosphoglucan phosphatase like sex four2 dephosphorylates starch at the C3-position in Arabidopsis

Published by

Plant Cell

Summary

journal-article

Structural basis for the glucan phosphatase activity of Starch Excess4

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Adenovirus protein E4orf4 induces premature APC<sup>Cdc20</sup> activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanism

Published by

Journal of Virology

Summary

journal-article

Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry

Published by

Biochemistry

Summary

journal-article

Lafora disease: insights into neurodegeneration from plant metabolism

Published by

Trends in Biochemical Sciences

Summary

journal-article

Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism

Published by

BMC Evolutionary Biology

Summary

journal-article

STARCH-EXCESS4 is a laforin-like phosphoglucan phosphatase required for starch degradation in Arabidopsis thaliana

Published by

Plant Cell

Summary

journal-article

Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)

Published by

Journal of Biological Chemistry

Summary

journal-article

The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease

Published by

Journal of Cell Biology

Summary

journal-article

A conserved phosphatase cascade that regulates nuclear membrane biogenesis

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease

Published by

Genes and Development

Summary

journal-article

An in vivo assay to quantify stable protein phosphatase 2A (PP2A) heterotrimeric species

Published by

Methods in Molecular Biology

Summary

book

Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates

Published by

Journal of Biological Chemistry

Summary

journal-article

A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers

Published by

Eukaryotic Cell

Summary

journal-article

Insights into Lafora disease: Malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Phosphorylation-dependent regulation of septin dynamics during the cell cycle

Published by

Developmental Cell

Summary

journal-article

Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle

Published by

Molecular Biology of the Cell

Summary

journal-article

Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation

Published by

Molecular and Cellular Biology

Summary

journal-article

Matthew Gentry