Human Stem Cell-Derived β-cells Expressing An Optimized CD155 Reduce Cytotoxic Immune Cell Function for Application in Type 1 Diabetes
Summary
preprint
Matthew Brown
About
Work
University of Florida
|Biological Scientist II - UF Diabetes Institute
US
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Education
University of Florida
United States of America
→
MD/PhD
University of Florida
United States of America
→
Bachelors of Interdisciplinary Studies - Biochemistry & Molecular Biology
Publications
Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes
Published by
Diabetologia
Summary
journal-article
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
Published by
Diabetologia
Summary
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Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
Published by
Diabetes
Summary
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Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells
Published by
The Journal of Immunology
Summary
journal-article
Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cells
Published by
Frontiers in Immunology
Summary
journal-article
Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy
Published by
Frontiers in immunology
Summary
journal-article
The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes
Published by
Frontiers in immunology
Summary
journal-article
192-LB: Human CD4+CD25+CD226- Regulatory T Cells Demonstrate High Purity and Lineage Stability following In Vitro Expansion for Adoptive Cell Therapy
Published by
Diabetes
Summary
journal-article