Amanda Merner, Ph.D.

Research Scientist & Instructor in Neuroethics and Affective Neuroscience
Boston, US.

About

Highly accomplished Ph.D. in Psychology with specialized expertise in Affective Neuroscience and Neuroethics, currently serving as a Research Scientist and Instructor at Massachusetts General Hospital and Harvard Medical School. Leads and contributes to externally funded mixed-methods studies focused on neuroethics, deep brain stimulation, and psychiatric genomics, consistently driving impactful research outcomes and securing significant grant support.

Work

Massachusetts General Hospital, Harvard Medical School
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Research Scientist, Instructor

Boston, Massachusetts, US

Summary

Leads and instructs on cutting-edge research in neuroethics and affective neuroscience within a leading academic medical center and prestigious university.

Highlights

Conducting advanced research in neurosurgery and bioethics, contributing to the Harvard Medical School's Department of Neurosurgery initiatives.

Instructing graduate-level courses, fostering the next generation of researchers in neuroethics and related fields.

Actively supported on multiple R01 NIH-funded projects, demonstrating consistent involvement in high-impact, externally recognized research.

Harvard Medical School
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Senior Scientist, Brain Bioethics Lab

Boston, Massachusetts, US

Summary

Directed advanced scientific research within the Brain Bioethics Lab, contributing to global health and social medicine initiatives.

Highlights

Spearheaded research as a Senior Scientist within the Brain Bioethics Lab, focusing on ethical considerations in neuroscience and global health.

Managed and contributed to multiple externally funded projects, including NIH R01MH133657, R01MH128676, R01MH114854, and R01NS119622, ensuring project milestones were met.

Collaborated with Principal Investigator Gabriel Lazaro-Muñoz, Ph.D., J.D., MBE, on complex bioethical research, enhancing project scope and impact.

Harvard Medical School
|

Postdoctoral Research Fellow

Boston, Massachusetts, US

Summary

Conducted advanced postdoctoral research in bioethics and global health, contributing to major externally funded projects.

Highlights

Executed critical research as a Postdoctoral Research Fellow in the Center for Bioethics and Department of Global Health and Social Medicine.

Provided key research support and analysis for multiple NIH R01 grants (R01MH133657, R01MH128676, R01MH114854, R01NS119622).

Collaborated closely with Principal Investigator Gabriel Lazaro-Muñoz, Ph.D., J.D., MBE, to advance research in neuroethics and related fields.

Cleveland Clinic
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Graduate Student Researcher

Cleveland, Ohio, US

Summary

Conducted impactful research within the Neurological Institute, contributing to externally funded projects under a leading investigator.

Highlights

Contributed to significant research initiatives at the Neurological Institute, focusing on advanced neurological studies.

Supported externally funded projects including RC1NS068086, R01MH114853, and R01MH123407, demonstrating expertise in grant-funded research environments.

Collaborated effectively with Principal Investigator Cynthia Kubu, Ph.D., to achieve research objectives and expand project scope.

Case Western Reserve University
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Graduate Student Researcher, Affective Neuroscience Lab

Cleveland, Ohio, US

Summary

Conducted in-depth research in affective neuroscience, contributing to key studies under the guidance of a distinguished Principal Investigator.

Highlights

Performed comprehensive research in the Affective Neuroscience Lab, specializing in complex psychological and neurological studies.

Worked directly with Principal Investigator Heath Demaree, Ph.D., gaining expertise in advanced research methodologies and data interpretation.

Managed research protocols and data collection efforts, ensuring high standards of scientific rigor and ethical compliance.

Case Western Reserve University
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Graduate Student Lab Associate, Skill Learning and Performance Lab

Cleveland, Ohio, US

Summary

Supported research in skill learning and performance, contributing to studies on cognitive processes and human capabilities.

Highlights

Assisted in research within the Skill Learning and Performance Lab, focusing on the acquisition and optimization of human skills.

Collaborated with Principal Investigator Brooke Macnamara, Ph.D., on experimental design, data analysis, and literature review.

Contributed to studies that explored high-level mental processes and their impact on performance outcomes.

Neuroqualia
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Graduate Student Researcher, The Human Affectome Project

Truro, Nova Scotia, Canada

Summary

Engaged in specialized research for The Human Affectome Project, analyzing complex emotional and cognitive data.

Highlights

Conducted detailed research for The Human Affectome Project, focusing on the intricate interplay of human emotion and cognition.

Worked under the guidance of Principal Investigator Edward Pace-Schott, Ph.D., contributing to the project's scientific objectives.

Analyzed complex datasets related to affective states, enhancing understanding of emotional processing and its neurological underpinnings.

Research Institute on Addictions
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Senior Research Analyst, Project Amethyst

Buffalo, New York, US

Summary

Managed and analyzed data for Project Amethyst, contributing to critical addiction research supported by external funding.

Highlights

Served as Senior Research Analyst for Project Amethyst, overseeing data collection and analysis for addiction research initiatives.

Contributed to externally funded projects (R01AA023179, R01AA024628, R01AA022080), demonstrating expertise in grant-funded research.

Collaborated with Principal Investigators Paul Stasiewicz, Ph.D., on study design and interpretation of findings related to addiction.

Research Institute on Addictions
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Research Assistant, Applied Psychophysiology Lab

Buffalo, New York, US

Summary

Provided essential research support for the Applied Psychophysiology Lab, contributing to externally funded studies on addiction.

Highlights

Assisted in research activities within the Applied Psychophysiology Lab, focusing on psychophysiological responses related to addiction.

Supported externally funded projects (R21AA017113, K23AA021768), gaining experience in grant management and research execution.

Worked under Principal Investigator Rebecca J. Houston, Ph.D., contributing to data collection, participant recruitment, and preliminary analysis.

Research Institute on Addiction
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Senior Research Analyst, Growing Up Healthy Study

Buffalo, New York, US

Summary

Conducted advanced data analysis for the 'Growing Up Healthy Study,' contributing to externally funded research on developmental health.

Highlights

Analyzed complex datasets for the 'Growing Up Healthy Study,' focusing on longitudinal developmental health outcomes.

Provided critical support for externally funded projects (R01DA019632, R01DA041231), ensuring data integrity and research progress.

Collaborated with Principal Investigator Rina Das Eiden, Ph.D., on interpreting findings and preparing research reports.

University at Buffalo
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Summer Undergraduate Research Assistant, Comparative Bioacoustics Laboratory

Buffalo, New York, US

Summary

Assisted in research at the Comparative Bioacoustics Laboratory, gaining foundational experience in scientific inquiry.

Highlights

Supported research in the Comparative Bioacoustics Laboratory, contributing to studies on animal communication and sensory processing.

Worked under Principal Investigator Michael Dent, Ph.D., gaining hands-on experience in experimental procedures and data collection.

Developed foundational research skills in a laboratory setting, preparing for advanced academic pursuits.

Education

Case Western Reserve University
Cleveland, Ohio, United States of America

Doctor of Philosophy (Ph.D.)

Psychology

Courses

Area of Specialization: Affective Neuroscience

Advisors: Heath Demaree, Ph.D., Cynthia S. Kubu, Ph.D.

Case Western Reserve University
Cleveland, Ohio, United States of America

Master of Arts (M.A.)

Psychology

Courses

Advisor: Heath Demaree, Ph.D.

The State University of New York at Buffalo
Buffalo, New York, United States of America

Bachelor of Science (B.S.)

Psychology

The State University of New York at Buffalo
Buffalo, New York, United States of America

Bachelor of Arts (B.A.)

Social Science Interdisciplinary, Cognitive Science Track

Courses

Focus Areas: High-level Mental Processes; Neuroscience

Awards

Best paper presentation

Awarded By

American Association of Neurological Surgeons Conference

Recognized for outstanding paper presentation at a national conference.

CWRU Distinguished Young Alumni Award

Awarded By

Case Western Reserve University

Awarded for significant achievements as a young alumnus.

Eva L. Pancoast Memorial Fellowship

Awarded By

Case Western Reserve University

Received a fellowship with a value of $2,500.

Ruth Moon Barber Award

Awarded By

Case Western Reserve University

Awarded for academic excellence with a value of $1,000.

Jane Kessler Award for Commitment to Scholarship in the Field of Disabilities

Awarded By

Case Western Reserve University

Recognized for dedication to scholarship in the field of disabilities.

Think Big Leadership Award

Awarded By

Case Western Reserve University

Nominated for leadership in innovative thinking.

The Joseph F. Fagan, III Award for Research Excellence

Awarded By

Case Western Reserve University

Received an award for research excellence with a value of $200.

CWRU GSC Professional Development Funds

Awarded By

Case Western Reserve University

Awarded professional development funds of $300.

Lenore A Kola Graduate Student Community Service Award

Awarded By

Case Western Reserve University

Nominated for outstanding community service as a graduate student.

The Joseph F. Fagan, III Award for Research Excellence

Awarded By

Case Western Reserve University

Received an award for research excellence with a value of $200.

APSSC Travel Grant Award

Awarded By

Association for Psychological Science Student Caucus

Received a travel grant of $450.

Psi Chi Honor Society

Awarded By

Psi Chi

Inducted into the international honor society in psychology.

Provost Scholarship

Awarded By

The State University of New York at Buffalo

Received a significant scholarship totaling $40,000.

Publications

Merner, A.R. & Lázaro-Muñoz, G. (Under Review) Neuromodulation in Psychiatry: How to Earn Patient and Physician Trust

Published by

Under Review

Summary

Explores strategies to build trust between patients, physicians, and neuromodulation therapies in psychiatry, addressing critical ethical and practical considerations.

Merner, A.R., Frazier, T.W., Ford, P.J., Lapin, B., Wilt, J., Racine, E., Gase, N., Leslie, E. Machado, A., Vitek, J., & Kubu, C.S. (2024). A Patient-Centered Perspective on Changes in Personal Characteristics after Deep Brain Stimulation.

Published by

JAMA Network Open

Summary

Explored patient-centered perspectives on personality changes following deep brain stimulation, providing critical insights into patient experiences and quality of life.

Merner, A.R., Trotter, P.M., Ginn, L.A, Bach, J., Freedberg, K.J., Soda, T., Storch, E.A., Pereira, S., & Lazaro-Muñoz, G. (2024). Psychiatric polygenic risk scores: Experience, hope for utility, and concerns among child and adolescent psychiatrists.

Published by

Psychiatry Research

Summary

Investigated the perspectives of child and adolescent psychiatrists on the utility, concerns, and experiences with psychiatric polygenic risk scores.

Merner, A.R. (May, 2022). A symptom-level network approach to exploring changes in depression before and after deep brain stimulation surgery.

Published by

American Society for Stereotactic and Functional Neurosurgery

Summary

Presented an invited talk on applying network analysis to understand depression changes pre- and post-DBS surgery, highlighting symptom-level interactions.

Merner, A.R. (2020). Managing productivity in the time of COVID-19.

Published by

APS Observer

Summary

Authored an article offering insights and strategies for maintaining research productivity during the COVID-19 pandemic.

Skills

Qualitative Software

NVivo, RQDA, QDA Miner, Dedoose.

Qualitative Methods

Natural Language Processing (NLP), Content Analysis, Thematic Analysis, Text Data Mining, Web Scraping, Large Language Models (LLM).

Research Expertise

Neuroethics, Affective Neuroscience, Deep Brain Stimulation (DBS), Psychiatric Genomics, Mixed-Methods Research, Grant Writing & Management, Stakeholder Engagement, Clinical Research, Experimental Design, Data Interpretation, Scientific Writing, Regulatory Compliance.

Teaching & Mentorship

Course Instruction, Curriculum Development, Student Mentoring, Research Supervision, Academic Pedagogy.

Statistical Software

R/R Studio, Mplus, SAS, Stan, SPSS, AMOS, JASP.

Statistical Methods

Frequentist Hypothesis Testing, Bayesian Analysis, Univariate and Multivariate Analyses, Linear and Nonlinear Modeling, Structural Equation Modeling (SEM), Dynamic Structural Equation Modeling (DSEM), Multilevel Modeling, Survival Analysis, Network Modeling, Dynamic Systems Modeling, Dyadic Modeling.

Physiological Methods

EKG (Electrocardiography), HRV (Heart Rate Variability), EDA (Electrodermal Activity), EEG (Electroencephalography), ERP (Event-Related Potentials), ERN (Error-Related Negativity), MRI (Magnetic Resonance Imaging), fMRI (functional Magnetic Resonance Imaging).

Psychophysiological Software

Biograph Infiniti, Neuroscan, Mindware, Curry, Biopac, Neuroquant.

Survey Software

REDCap, Qualtrics.

Stimulus Presentation Software

SuperLab, E-Prime, Psychopy.

Projects

Promoting Access and Uptake of Implantable Neuromodulation Devices (NIH R01) (Submitted for Funding)

Summary

Conduct mixed-methods study to examine and model factors contributing to disparities related to access to deep brain stimulation and gain insights from patients and clinicians regarding potential solutions to these disparities.

Genomic Tests for Substance Use Disorders in Clinical Care: Examining Challenges and Opportunities (NIH R01DA062848)

Summary

Examine the views, concerns, expectations, decision-making factors, and proposals of various stakeholders regarding the use of genetic tests for opioid use disorder (OUD) in medical settings, using a mixed-method approach.

Spaulding-Harvard Traumatic Brain Injury Model System (Department of Health and Human Services)

Summary

This study will examine perspectives of patients with traumatic brain injury, their caregivers, and physicians on what is considered a “favorable” and “unfavorable” long-term outcome from TBI.

Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research (NIH R01)

Summary

Conduct in-depth interviews with former participants in experimental DBS, their care partners, and their local physicians as well as researchers, device manufacturers, insurance providers, and key administrative personnel (i.e., representatives of academic medical centers, FDA, public and private research sponsors) regarding challenges and opportunities for post-trial device access, clinical care, and psychosocial support, as well as the scientific possibilities of extended device access and longitudinal follow up.

Exploring Patient-Preferred Terminology for Deep Brain Stimulation (DBS) (University of Florida, Norman Fixel Institute)

Summary

Conduct stakeholder interviews with patients with Parkinson's disease who received DBS, patients who declined DBS, and members of the general public to examine terminology used to describe DBS and determine how this terminology can act as a barrier or facilitator to exploring DBS as a treatment option. Results will be presented to experts at the annual DBS Think Tank for a large-scale focus group exploring how to improve and align terminology to describe DBS to patients.

Caregiver Perspectives on Changes Following Responsive Neurostimulation for Lennox-Gastaut Syndrome (NIH Supplement) (Submitted for Funding)

Summary

Conduct mixed-methods study to systematically identify and assess caregiver perspectives on the impacts of responsive neurostimulation (RNS) in the functioning and quality of life of patients living with LGS and their families; findings will inform the development of a patient- and caregiver-centered outcome framework for evaluating neurostimulation interventions in LGS patients.

Polygenic Risk Scores in Child and Adolescent Psychiatry: Ethical, Clinical, and Legal Implications (NIH R01)

Summary

Conduct a mixed-methods study to promote responsible use of psychiatric PRS in children and adolescents. Goals: 1) give voice to stakeholders (i.e., patients, parents/caregivers, clinicians) by examining their perspectives regarding whether psychiatric PRS should be used and, if so, how; and 2) examine the legal and regulatory landscape to identify what privacy and genetic discrimination safeguards may be necessary.

Neural Underpinnings of Personality Change in Neurodegenerative Disorders (Cleveland Clinic Imaging Institute)

Summary

Investigate differences in the type of personality characteristics patients and family members value most, perceived changes in those characteristics, and potential neural underpinnings of these changes, in five different groups of patients with neurodegenerative disorders.

Amanda Merner, Ph.D.