Mireille ANSALDI

, , ,.

About

Research in our group focuses on different aspect of bacteriophage biology and applications. On one hand, we aim at elucidating host-phage interactions using up to date molecular and imaging approaches. We essentially focus on phage infection and lysogenic conversion to understand how this shapes bacterial genome evolution and influences the host physiology using several bacterial models such as Escherichia coli, Salmonella enterica and Xyllela fastidiosa. Also using virulent phage models such as T5, we aim at elucidating the regulatory interplays between phage and host genes and decipher how the host regulatory network influence (pro)phage gene expression and vice versa. On the other hand, and based on the knowledge acquired on phage biology, we develop phage-based biotechnological tools such as highly specific biosensors that only detect alive bacteria. We are also interested in the use of phage as therapeutic tools in combination or not with antibiotics. The molecular mechanisms underlying phage-antibiotic synergistic effect are studied using T5 as a model system.

Work

CNRS

, , France

Summary

Public Health Research Institute

Postdoc

, , US

Apr 2000→ Sep 2002

Summary

Education

Aix-Marseille Université

, , France

Oct 1996→ Mar 2000

PhD

Publications

Les virus des bactéries à l’ère de l’Anthropocène : amis ou ennemis de leurs hôtes ?

médecine/sciences

Jan 2025

journal-article

HieVi: Protein Large Language Model for proteome-based phage clustering

Jan 2024

preprint

Antibiotic-Induced Morphological Changes Enhance Phage Propagation: A Mathematical Model of Plaque Formation in Structured Environments

Jan 2024

preprint

The prophage-encoded transcriptional regulator AppY has pleiotropic effects on E. coli physiology

PLOS Genetics

Jan 2023

journal-article

Phage-antibiotic synergy: Cell filamentation is a key driver of successful phage predation

PLOS Pathogens

Jan 2023

journal-article

Genetic Mining of Newly Isolated Salmophages for Phage Therapy

International Journal of Molecular Sciences

Jan 2022

journal-article

Phage-antibiotic synergy: cell filamentation is a key driver of successful phage predation

Jan 2022

preprint

Cover Feature: Probing the Structural Dynamics of a Bacterial Chaperone in Its Native Environment by Nitroxide‐Based EPR Spectroscopy (Chem. Eur. J. 66/2022)

Chemistry – A European Journal

Jan 2022

journal-article

Probing the Structural Dynamics of a Bacterial Chaperone in Its Native Environment by Nitroxide‐Based EPR Spectroscopy

Chemistry – A European Journal

Jan 2022

journal-article

Genetic Mining of Newly Isolated Salmophages for Phage Therapy

International Journal of Molecular Sciences

Jan 2022

journal-article

Genetic mining of newly isolated Salmophages for phage therapy

Jan 2022

preprint

Pleiotropic effects on E. coli physiology of the AraC-like regulator from prophage origin, AppY

Jan 2022

preprint

Novel Virulent Bacteriophages Infecting Mediterranean Isolates of the Plant Pest Xylella fastidiosa and Xanthomonas albilineans

Viruses

Jan 2021

journal-article

Novel Virulent Bacteriophages Infecting Mediterranean Isolates of the Plant Pest Xylella fastidiosa and Xanthomonas albilineans

Viruses

Jan 2021

journal-article

Antibacterial applications of bacteriophages

Virologie

Jan 2020

journal-article

Epigenetic biosensors for bacteriophage detection and phage receptor discrimination

Environmental Microbiology

Jan 2020

journal-article

A century of research on bacteriophages

Virologie

Jan 2020

journal-article

Prophages in Salmonella enterica: a driving force in reshaping the genome and physiology of their bacterial host?

Molecular Microbiology

Jan 2019

journal-article

“French Phage Network”—Third Meeting Report

Viruses

Jan 2018

journal-article

Prophages in Salmonella enterica: a driving force in reshaping the genome and physiology of their bacterial host?

Molecular microbiology

Jan 2018

journal-article

“French Phage Network”—Third Meeting Report

Viruses

Jan 2018

journal-article

Substrate-independent luminescent phage-based biosensor to specifically detect enteric bacteria such as E. coli

Environmental Science and Pollution Research

Jan 2017

journal-article

French phage network—second meeting report

Viruses

Jan 2017

journal-article

“French Phage Network”—Second Meeting Report

Viruses

Jan 2017

journal-article

Semi-autonomous inline water analyzer: design of a common light detector for bacterial, phage, and immunological biosensors

Environmental Science and Pollution Research

Jan 2017

journal-article

Toward inline multiplex biodetection of metals, bacteria, and toxins in water networks: the COMBITOX project

Environmental Science and Pollution Research

Jan 2017

journal-article

Phage-based fluorescent biosensor prototypes to specifically detect enteric bacteria such as E. coli and Salmonella enterica Typhimurium

PLoS ONE

Jan 2015

journal-article

Bacterial genome remodeling through bacteriophage recombination

FEMS Microbiology Letters

Jan 2015

journal-article

The primary pathway for lactate oxidation in Desulfovibrio vulgaris

Frontiers in Microbiology

Jan 2015

journal-article

Transcription termination controls prophage maintenance in Escherichia coli genomes

Proceedings of the National Academy of Sciences of the United States of America

Jan 2013

journal-article

Cell biology perspectives in phage biology

Frontiers in Bioscience - Elite

Jan 2012

journal-article

Cell biology perspectives in phage biology.

Frontiers in bioscience (Elite edition)

Jan 2012

journal-article

DnaJ (Hsp40 protein) binding to folded substrate impacts KplE1 prophage excision efficiency

Journal of Biological Chemistry

Jan 2012

journal-article

Insights into the functions of a prophage recombination directionality factor

Viruses

Jan 2012

journal-article

Insights into the Functions of a Prophage Recombination Directionality Factor

Viruses

Jan 2012

journal-article

Chaperone-assisted excisive recombination, a solitary role for DnaJ (Hsp40) chaperone in lysogeny escape

Journal of Biological Chemistry

Jan 2011

journal-article

The anaerobe-specific orange protein complex of Desulfovibrio vulgaris hildenborough is encoded by two divergent operons coregulated by σ⁵⁴ and a cognate transcriptional regulator

Journal of Bacteriology

Jan 2011

journal-article

The cyst-dividing bacterium ramlibacter tataouinensis TTB310 genome reveals a well-stocked toolbox for adaptation to a desert environment

PLoS ONE

Jan 2011

journal-article

Protein binding sites involved in the assembly of the KplE1 prophage intasome

Virology

Jan 2010

journal-article

Tight regulation of the intS Gene of the KplE1 prophage: A new paradigm for integrase gene regulation

PLoS Genetics

Jan 2010

journal-article

P2CS: A two-component system resource for prokaryotic signal transduction research

BMC Genomics

Jan 2009

journal-article

Aerobic TMAO respiration in Escherichia coli

Molecular Microbiology

Jan 2007

journal-article

Control and regulation of KplE1 prophage site-specific recombination: A new recombination module analyzed

Journal of Biological Chemistry

Jan 2007

journal-article

Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor

Journal of Biological Chemistry

Jan 2005

journal-article

Diversifying Selection at the Bacillus Quorum-Sensing Locus and Determinants of Modification Specificity during Synthesis of the ComX Pheromone

Journal of Bacteriology

Jan 2004

journal-article

Genes regulated by TorR, the trimethylamine oxide response regulator of Shewanella oneidensis

Journal of Bacteriology

Jan 2004

journal-article

TorI, a response regulator inhibitor of phage origin in Escherichia coli

Proceedings of the National Academy of Sciences of the United States of America

Jan 2004

journal-article

Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants.

Molecular microbiology

Jan 2002

journal-article

Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants

Molecular Microbiology

Jan 2002

journal-article

Rapid dephosphorylation of the TorR response regulator by the TorS unorthodox sensor in Escherichia coli.

Journal of bacteriology

Jan 2001

journal-article

Rapid dephosphorylation of the TorR response regulator by the TorS unorthodox sensor in Escherichia coli

Journal of Bacteriology

Jan 2001

journal-article

The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.

Journal of bacteriology

Jan 2000

journal-article

The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli

Journal of Bacteriology

Jan 2000

journal-article

TorC apocytochrome negatively autoregulates the trimethylamine N-oxide (TMAO) reductase operon in Escherichia coli.

Molecular microbiology

Jan 1999

journal-article

TorC apocytochrome negatively autoregulates the trimethylamine N-oxide (TMAO) reductase operon in Escherichia coli

Molecular Microbiology

Jan 1999

journal-article

Transphosphorylation of the TorR response regulator requires the three phosphorylation sites of the TorS unorthodox sensor in Escherichia coli.

Journal of molecular biology

Jan 1997

journal-article

Transphosphorylation of the TorR response regulator requires the three phosphorylation sites of the TorS unorthodox sensor in Escherichia coli

Journal of Molecular Biology

Jan 1997

journal-article

Site-specific mutagenesis by using an accurate recombinant polymerase chain reaction method.

Analytical biochemistry

Jan 1996

journal-article

Site-specific mutagenesis by using an accurate recombinant polymerase chain reaction method

Analytical Biochemistry

Jan 1996

journal-article

Binding of the TorR regulator to cis-acting direct repeats activates tor operon expression.

Molecular microbiology

Jan 1995

journal-article

Binding of the TorR regulator to cis‐acting direct repeats activates tor operon expression

Molecular Microbiology

Jan 1995

journal-article

Mireille ANSALDI

About

Work

CNRS

Public Health Research Institute

Education

Aix-Marseille Université

Publications

Les virus des bactéries à l’ère de l’Anthropocène : amis ou ennemis de leurs hôtes ?

HieVi: Protein Large Language Model for proteome-based phage clustering

Antibiotic-Induced Morphological Changes Enhance Phage Propagation: A Mathematical Model of Plaque Formation in Structured Environments

The prophage-encoded transcriptional regulator AppY has pleiotropic effects on E. coli physiology

Phage-antibiotic synergy: Cell filamentation is a key driver of successful phage predation

Genetic Mining of Newly Isolated Salmophages for Phage Therapy

Phage-antibiotic synergy: cell filamentation is a key driver of successful phage predation

Cover Feature: Probing the Structural Dynamics of a Bacterial Chaperone in Its Native Environment by Nitroxide‐Based EPR Spectroscopy (Chem. Eur. J. 66/2022)

Probing the Structural Dynamics of a Bacterial Chaperone in Its Native Environment by Nitroxide‐Based EPR Spectroscopy

Genetic Mining of Newly Isolated Salmophages for Phage Therapy

Genetic mining of newly isolated Salmophages for phage therapy

Pleiotropic effects on E. coli physiology of the AraC-like regulator from prophage origin, AppY

Novel Virulent Bacteriophages Infecting Mediterranean Isolates of the Plant Pest Xylella fastidiosa and Xanthomonas albilineans

Novel Virulent Bacteriophages Infecting Mediterranean Isolates of the Plant Pest Xylella fastidiosa and Xanthomonas albilineans

Antibacterial applications of bacteriophages

Epigenetic biosensors for bacteriophage detection and phage receptor discrimination

A century of research on bacteriophages

Prophages in Salmonella enterica: a driving force in reshaping the genome and physiology of their bacterial host?

“French Phage Network”—Third Meeting Report

Prophages in Salmonella enterica: a driving force in reshaping the genome and physiology of their bacterial host?

“French Phage Network”—Third Meeting Report

Substrate-independent luminescent phage-based biosensor to specifically detect enteric bacteria such as E. coli

French phage network—second meeting report

“French Phage Network”—Second Meeting Report

Semi-autonomous inline water analyzer: design of a common light detector for bacterial, phage, and immunological biosensors

Toward inline multiplex biodetection of metals, bacteria, and toxins in water networks: the COMBITOX project

Phage-based fluorescent biosensor prototypes to specifically detect enteric bacteria such as E. coli and Salmonella enterica Typhimurium

Bacterial genome remodeling through bacteriophage recombination

The primary pathway for lactate oxidation in Desulfovibrio vulgaris

Transcription termination controls prophage maintenance in Escherichia coli genomes

Cell biology perspectives in phage biology

Cell biology perspectives in phage biology.

DnaJ (Hsp40 protein) binding to folded substrate impacts KplE1 prophage excision efficiency

Insights into the functions of a prophage recombination directionality factor

Insights into the Functions of a Prophage Recombination Directionality Factor

Chaperone-assisted excisive recombination, a solitary role for DnaJ (Hsp40) chaperone in lysogeny escape

The anaerobe-specific orange protein complex of Desulfovibrio vulgaris hildenborough is encoded by two divergent operons coregulated by σ54 and a cognate transcriptional regulator

The cyst-dividing bacterium ramlibacter tataouinensis TTB310 genome reveals a well-stocked toolbox for adaptation to a desert environment

Protein binding sites involved in the assembly of the KplE1 prophage intasome

Tight regulation of the intS Gene of the KplE1 prophage: A new paradigm for integrase gene regulation

P2CS: A two-component system resource for prokaryotic signal transduction research

Aerobic TMAO respiration in Escherichia coli

Control and regulation of KplE1 prophage site-specific recombination: A new recombination module analyzed

Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor

Diversifying Selection at the Bacillus Quorum-Sensing Locus and Determinants of Modification Specificity during Synthesis of the ComX Pheromone

Genes regulated by TorR, the trimethylamine oxide response regulator of Shewanella oneidensis

TorI, a response regulator inhibitor of phage origin in Escherichia coli

Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants.

Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants

Rapid dephosphorylation of the TorR response regulator by the TorS unorthodox sensor in Escherichia coli.

Rapid dephosphorylation of the TorR response regulator by the TorS unorthodox sensor in Escherichia coli

The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.

The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli

TorC apocytochrome negatively autoregulates the trimethylamine N-oxide (TMAO) reductase operon in Escherichia coli.

TorC apocytochrome negatively autoregulates the trimethylamine N-oxide (TMAO) reductase operon in Escherichia coli

Transphosphorylation of the TorR response regulator requires the three phosphorylation sites of the TorS unorthodox sensor in Escherichia coli.

Transphosphorylation of the TorR response regulator requires the three phosphorylation sites of the TorS unorthodox sensor in Escherichia coli

Site-specific mutagenesis by using an accurate recombinant polymerase chain reaction method.

Site-specific mutagenesis by using an accurate recombinant polymerase chain reaction method

Binding of the TorR regulator to cis-acting direct repeats activates tor operon expression.

Binding of the TorR regulator to cis‐acting direct repeats activates tor operon expression

The anaerobe-specific orange protein complex of Desulfovibrio vulgaris hildenborough is encoded by two divergent operons coregulated by σ⁵⁴ and a cognate transcriptional regulator