Mireille ANSALDI
About
Research in our group focuses on different aspect of bacteriophage biology and applications. On one hand, we aim at elucidating host-phage interactions using up to date molecular and imaging approaches. We essentially focus on phage infection and lysogenic conversion to understand how this shapes bacterial genome evolution and influences the host physiology using several bacterial models such as Escherichia coli, Salmonella enterica and Xyllela fastidiosa. Also using virulent phage models such as T5, we aim at elucidating the regulatory interplays between phage and host genes and decipher how the host regulatory network influence (pro)phage gene expression and vice versa. On the other hand, and based on the knowledge acquired on phage biology, we develop phage-based biotechnological tools such as highly specific biosensors that only detect alive bacteria. We are also interested in the use of phage as therapeutic tools in combination or not with antibiotics. The molecular mechanisms underlying phage-antibiotic synergistic effect are studied using T5 as a model system.