Nathan Jones

About

A highly motivated scientist with strong interpersonal skills and a demonstrated ability to effectively lead and integrate information from various disciplines in a collaborative environment. A dedicated researcher with seven years of experience and expertise in molecular pharmacology and chemical neuroscience excelling in: - Experimental design - Assay development - Optimization, - LC-MS/MS, - Pharmacokinetics, - Pharmacodynamics - Comprehensive data analysis - Data visualization I have a strong background in testing, analyzing, and validating novel therapeutic compounds. I am passionate about developing effective therapeutics and am committed to continuing this work, aiming to create innovative treatments that improve patient outcomes and enhance quality of life. As a dedicated researcher with seven years of experience in molecular pharmacology and chemical neuroscience, My expertise and research with rapid-acting antidepressants focused on the pharmacokinetic and pharmacodynamic profiling of compounds like psilocybin, where my work contributed novel findings on the interaction between drug-induced stress responses and anxiolytic efficacy. Furthermore, this work led to the testing of 7 alternative compounds, which resulted in the first direct pharmacokinetic evidence and validation for psilacetin as an alternative to psilocybin. I also performed a comparative study in collaboration with an industry partner, Psilera, to characterize the pharmacokinetic and pharmacodynamic profiles for different routes of administration. I am driven by a passion for advancing research that paves the way for innovative and effective treatments in mental health.

Work

Mayo Clinic in Rochester, Minnesota

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Post Doctoral Research Fellow

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University of Wisconsin School of Medicine and Public Health

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Research Assistant/Ph.D. Student

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University of South Dakota

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Undergraduate Research Assistant

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SUNY Buffalo State University

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Undergraduate Research Assistant

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South Dakota Biomedical Research Infrastructure Network

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Undergraduate Research Assistant/Intern

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Education

University of Wisconsin–Madison

United States of America
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Ph.D. in Molecular and Cellular Pharmacology

University of South Dakota

United States of America
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Physiology, Cell and Molecular (B.S.)

University of South Dakota

United States of America
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Anthropology (B.S.)

Publications

Acute carbamoylated erythropoietin reduces social stress-induced anxiety and depression-related behaviors

Neuropharmacology

journal-article

Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT)

European Journal of Pharmaceutical Sciences

journal-article

Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT)

European Journal of Pharmaceutical Sciences

journal-article

In Vivo Validation of Psilacetin as a Prodrug Yielding Modestly Lower Peripheral Psilocin Exposure than Psilocybin

Frontiers in Psychiatry

journal-article

Transient Elevation of Plasma Glucocorticoids Supports Psilocybin-Induced Anxiolysis in Mice

ACS Pharmacology & Translational Science

journal-article

Catalysts for change: the cellular neurobiology of psychedelics

Molecular Biology of the Cell

journal-article

Delayed Anxiolytic-Like Effects of Psilocybin in Male Mice Are Supported by Acute Glucocorticoid Release

preprint

A Traditional Medicine's Deep Time History and Rethinking Depression

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dissertation-thesis