Ramon Arens

Education

Academic Medical Center
Netherlands

→

PhD

Publications

Metabolic profiling of antigen-specific CD8+ T cells by spectral flow cytometry

Published by

Cell Reports Methods

Summary

journal-article

Limited protection against early-life cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells

Summary

preprint

Multiantigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses.

Published by

JCI insight

Summary

journal-article

Delayed vaccine-induced CD8+T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication

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Journal for ImmunoTherapy of Cancer

Summary

journal-article

Immunophenotyping beyond the limits of time.

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Cell Reports Methods

Summary

journal-article

Enhanced HPV16 E6/E7<sup>+</sup> tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides.

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Cancer Immunology, Immunotherapy

Summary

journal-article

OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.

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Cell Reports Medicine

Summary

journal-article

Chronic lymphocytic leukemia presence impairs antigen-specific CD8<sup>+</sup> T-cell responses through epigenetic reprogramming towards short-lived effectors.

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Leukemia

Summary

journal-article

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

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Frontiers in Immunology

Summary

journal-article

Dominant Antiviral CD8+ T Cell Responses Empower Prophylactic Antibody-Eliciting Vaccines Against Cytomegalovirus.

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Frontiers in Immunology

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journal-article

CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.

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Journal for Immunotherapy of Cancer

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journal-article

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model.

Published by

Gut

Summary

journal-article

CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors

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Journal for ImmunoTherapy of Cancer

Summary

journal-article

CRISPR Activation Screening Identifies VGLL3-TEAD1-RUNX1/3 as a Transcriptional Complex for PD-L1 Expression.

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The Journal of Immunology

Summary

journal-article

CRISPR Activation Screening Identifies VGLL3–TEAD1–RUNX1/3 as a Transcriptional Complex for PD-L1 Expression

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The Journal of Immunology

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journal-article

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection.

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Nature Communications

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journal-article

mTORC1 signaling in antigen-presenting cells of the skin restrains CD8<sup>+</sup> T cell priming.

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Cell Reports

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journal-article

mTORC1 signaling in antigen-presenting cells of the skin restrains CD8+ T cell priming

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Cell Reports

Summary

journal-article

Editorial: Immunity to Cytomegalovirus Infections: Challenges and Therapeutic Opportunities.

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Frontiers in Immunology

Summary

journal-article

Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination.

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Vaccine

Summary

journal-article

The curious case of IL‐33 in homeostasis and infection

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European Journal of Immunology

Summary

journal-article

Cytomegalovirus subverts macrophage identity.

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Cell

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journal-article

IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors.

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Journal for Immunotherapy of Cancer

Summary

journal-article

Functional Heterogeneity and Therapeutic Targeting of Tissue-Resident Memory T Cells.

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Cells

Summary

journal-article

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3<sup>*</sup>Leiden Mice via Systemic Inhibition of Regulatory T Cells.

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Frontiers in Cardiovascular Medicine

Summary

journal-article

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

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EMBO Reports

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journal-article

'Reverse evolution' in T cell biology.

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Nature Immunology

Summary

journal-article

The curious case of IL-33 in homeostasis and infection.

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European Journal of Immunology

Summary

journal-article

Memory CD8<sup>+</sup> T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment.

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iScience

Summary

journal-article

Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer.

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Journal for Immunotherapy of Cancer

Summary

journal-article

Interleukin-6-mediated resistance to immunotherapy is linked to impaired myeloid cell function.

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International Journal of Cancer

Summary

journal-article

Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models.

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Journal for Immunotherapy of Cancer

Summary

journal-article

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy.

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Journal for Immunotherapy of Cancer

Summary

journal-article

Tissue-resident memory CD8<sup>+</sup> T cells shape local and systemic secondary T cell responses.

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Nature Immunology

Summary

journal-article

Genetic Screening for Novel Regulators of Immune Checkpoint Molecules.

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Trends in Immunology

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journal-article

Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention.

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Toxicology Reports

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journal-article

Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention

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Toxicology Reports

Summary

journal-article

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.

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Proc Natl Acad Sci USA

Summary

journal-article

CD8+ T Cells Protect During Vein Graft Disease Development.

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Frontiers in Cardiovascular Medicine

Summary

journal-article

Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore.

Published by

Journal of Visualized Experiments

Summary

journal-article

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.

Published by

Nature Reviews Cardiology

Summary

journal-article

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer.

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Oncoimmunology

Summary

journal-article

A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control.

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Oncoimmunology

Summary

journal-article

PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors.

Published by

Journal for Immunotherapy of Cancer

Summary

journal-article

The hallmarks of CMV-specific CD8 T-cell differentiation.

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Medical Microbiology and Immunology

Summary

journal-article

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8<sup>+</sup> T cells in the bone marrow.

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European Journal of Immunology

Summary

journal-article

Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection.

Published by

Journal for Immunotherapy of Cancer

Summary

journal-article

TRMmaintenance is regulated by tissue damage via P2RX7.

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Science Immunology

Summary

journal-article

T RM maintenance is regulated by tissue damage via P2RX7

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Science Immunology

Summary

journal-article

<i>Cytofast</i>: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations.

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Computational and Structural Biotechnology Journal

Summary

journal-article

Cytomegalovirus infection and progressive differentiation of effector-memory T cells.

Published by

F1000Research

Summary

journal-article

Impact of congenital cytomegalovirus infection on transcriptomes from archived dried blood spots in relation to long-term clinical outcome.

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PloS One

Summary

journal-article

OX40 Stimulation Enhances Protective Immune Responses Induced After Vaccination With Attenuated Malaria Parasites.

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Frontiers in Cellular and Infection Microbiology

Summary

journal-article

FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines.

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Oncotarget

Summary

journal-article

The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis.

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International Journal of Cardiology

Summary

journal-article

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells.

Published by

The Journal of Experimental Medicine

Summary

journal-article

Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.

Published by

Frontiers in Immunology

Summary

journal-article

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose.

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Frontiers in Immunology

Summary

journal-article

Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection.

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Trends in Microbiology

Summary

journal-article

Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells.

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Kidney International

Summary

journal-article

CMV immune evasion and manipulation of the immune system with aging.

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GeroScience

Summary

journal-article

CD4<sup>+</sup> T Cell and NK Cell Interplay Key to Regression of MHC Class I<sup>low</sup> Tumors upon TLR7/8 Agonist Therapy.

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Cancer Immunology Research

Summary

journal-article

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

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Atherosclerosis

Summary

journal-article

Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation.

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Scientific Reports

Summary

journal-article

Enforced OX40 Stimulation Empowers Booster Vaccines to Induce Effective CD4<sup>+</sup> and CD8<sup>+</sup> T Cell Responses against Mouse Cytomegalovirus Infection.

Published by

Frontiers in Immunology

Summary

journal-article

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors.

Published by

PLoS Pathogens

Summary

journal-article

Wnt Signaling as Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy.

Published by

Transplantation

Summary

journal-article

The importance of correctly timing cancer immunotherapy.

Published by

Expert Opinion on Biological Therapy

Summary

journal-article

The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection.

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PLoS Pathogens

Summary

journal-article

Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination.

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Frontiers in Immunology

Summary

journal-article

Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells.

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Cancer Research

Summary

journal-article

Viral Persistence Induces Antibody Inflation without Altering Antibody Avidity.

Published by

Journal of Virology

Summary

journal-article

Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses.

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Science Translational Medicine

Summary

journal-article

Vaccines for established cancer: overcoming the challenges posed by immune evasion.

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Nature Reviews Cancer

Summary

journal-article

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity.

Published by

Immunity

Summary

journal-article

Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection.

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The Journal of General Virology

Summary

journal-article

The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells.

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The Journal of Immunology

Summary

journal-article

The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells

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The Journal of Immunology

Summary

journal-article

Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model.

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Arthritis Research & Therapy

Summary

journal-article

The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.

Published by

eLife

Summary

journal-article

Cytomegalovirus- and Epstein-Barr Virus-Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study.

Published by

The Journal of Infectious Diseases

Summary

journal-article

New approaches in vaccine-based immunotherapy for human papillomavirus-induced cancer.

Published by

Current Opinion in Immunology

Summary

journal-article

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.

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Cancer Immunology Research

Summary

journal-article

5(th) International Workshop on CMV and Immunosenescence - A shadow of cytomegalovirus infection on immunological memory.

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European Journal of Immunology

Summary

journal-article

Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.

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PLoS Pathogens

Summary

journal-article

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.

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Arthritis Research & Therapy

Summary

journal-article

Therapeutic cancer vaccines.

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The Journal of Clinical Investigation

Summary

journal-article

Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death.

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Clinical Cancer Research

Summary

journal-article

T Cell factor 1 represses CD8+ effector T cell formation and function.

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The Journal of Immunology

Summary

journal-article

The activation of the adaptive immune system: cross-talk between antigen-presenting cells, T cells and B cells.

Published by

Immunology Letters

Summary

journal-article

Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice.

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PloS One

Summary

journal-article

New advances in CMV and immunosenescence.

Published by

Experimental Gerontology

Summary

journal-article

Viral inoculum dose impacts memory T-cell inflation.

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European Journal of Immunology

Summary

journal-article

Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung.

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PLoS Pathogens

Summary

journal-article

An unexpected intriguing effect of Toll-like receptor regulator RP105 (CD180) on atherosclerosis formation with alterations on B-cell activation.

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Arteriosclerosis, Thrombosis, and Vascular Biology

Summary

journal-article

Local immunomodulation for cancer therapy: Providing treatment where needed.

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Oncoimmunology

Summary

journal-article

The distinct role of T cell costimulation in antiviral immunity.

Published by

Current Opinion in Virology

Summary

journal-article

Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects.

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Clinical Cancer Research

Summary

journal-article

Lysine acetyltransferase PCAF is a key regulator of arteriogenesis.

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Arteriosclerosis, Thrombosis, and Vascular Biology

Summary

journal-article

CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.

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Journal of Virology

Summary

journal-article

Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer.

Published by

Seminars in Immunology

Summary

journal-article

Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.

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The Journal of Immunology

Summary

journal-article

T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development.

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International Journal of Cardiology

Summary

journal-article

Predicting the efficacy of cancer vaccines by evaluating T-cell responses.

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Oncoimmunology

Summary

journal-article

Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors.

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The Journal of Immunology

Summary

journal-article

Polyfunctional CD4+ T cell responses to immunodominant epitopes correlate with disease activity of virulent Salmonella.

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PloS One

Summary

journal-article

Local targets for immune therapy to cancer: tumor draining lymph nodes and tumor microenvironment.

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International Journal of Cancer

Summary

journal-article

The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions.

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Nature Communications

Summary

journal-article

Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets.

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Immunity

Summary

journal-article

CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.

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The Journal of Immunology

Summary

journal-article

Memory T cell inflation: understanding cause and effect.

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Trends in Immunology

Summary

journal-article

Rational design of vaccines: learning from immune evasion mechanisms of persistent viruses and tumors.

Published by

Advances in Immunology

Summary

journal-article

Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression.

Published by

Blood

Summary

journal-article

Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.

Published by

Nature Immunology

Summary

journal-article

Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells.

Published by

Nature Immunology

Summary

journal-article

Dissecting the requirements for maintenance of the CMV-specific memory T-cell pool.

Published by

Viral Immunology

Summary

journal-article

Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells.

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The Journal of Experimental Medicine

Summary

journal-article

B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.

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The Journal of Immunology

Summary

journal-article

Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody.

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Clinical Cancer Research

Summary

journal-article

Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.

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The Journal of Immunology

Summary

journal-article

Immunotherapy for persistent viral infections and associated disease.

Published by

Trends in Immunology

Summary

journal-article

The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice.

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The Journal of Clinical Investigation

Summary

journal-article

B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence.

Published by

Journal of Virology

Summary

journal-article

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells.

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Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Plasticity in programming of effector and memory CD8 T-cell formation.

Published by

Immunological Reviews

Summary

journal-article

Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient.

Published by

Science

Summary

journal-article

Protective CD8 T cell memory is impaired during chronic CD70-driven costimulation.

Published by

The Journal of immunology

Summary

journal-article

Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.

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The Journal of Immunology

Summary

journal-article

Dissecting T cell lineage relationships by cellular barcoding.

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The Journal of Experimental Medicine

Summary

journal-article

Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response.

Published by

The Journal of Immunology

Summary

journal-article

CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.

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International Immunology

Summary

journal-article

IL-12 deficiency transiently improves viral clearance during the late phase of respiratory tract infection with influenza A virus in mice.

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Antiviral Research

Summary

journal-article

Dissection of cytotoxic and helper T cell responses.

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Cellular and Molecular Life Sciences : CMLS

Summary

journal-article

Properties of murine (CD8+)CD27- T cells.

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European Journal of Immunology

Summary

journal-article

Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation.

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The Journal of Immunology

Summary

journal-article

Immune activation modulates hematopoiesis through interactions between CD27 and CD70.

Published by

Nature Immunology

Summary

journal-article

Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus.

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Immunology

Summary

journal-article

Signaling through CD70 regulates B cell activation and IgG production.

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The Journal of Immunology

Summary

journal-article

Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation.

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The Journal of Experimental Medicine

Summary

journal-article

B cells are crucial for both development and maintenance of the splenic marginal zone.

Published by

The Journal of Immunology

Summary

journal-article

Expression of the murine CD27 ligand CD70 in vitro and in vivo.

Published by

The Journal of Immunology

Summary

journal-article

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.

Published by

Nature Immunology

Summary

journal-article

Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.

Published by

Immunity

Summary

journal-article