Heterotypic Seeding Generates Mixed Amyloid Polymorphs
Published by
Small Science
Summary
journal-article
Siddhartha Banerjee
About
Postdoctoral Associate in the Department of Chemistry and Chemical Biology at Rutgers University, specializing in the structural analysis of amyloid aggregation in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. My current research focuses on uncovering structural motifs that drive amyloid aggregation. Previously, I explored the structural evolution of early-stage amyloid protein aggregates using advanced techniques like Atomic Force Microscopy (AFM) and nanoscale vibrational spectroscopy (AFM-IR). This work provided insights into the morphology and secondary structure of individual amyloid fibrils. I also investigated how neuronal membranes influence amyloid protein aggregation, leveraging high-resolution time-lapse AFM imaging to capture the aggregation process in real time. Passionate about applying cutting-edge analytical methods to unravel the molecular mechanisms underlying neurodegenerative diseases.
Work
Rutgers, The State University of New Jersey
US
Education
Rutgers, The State University of New Jersey
United States of America
The University of Alabama
United States of America
Postdoctoral Researcher
University of Nebraska Medical Center College of Pharmacy
United States of America
Postdoctoral Research Associate
Indian Association for the Cultivation of Science
India
Research Associate
Indian Association for the Cultivation of Science
India
PhD
Publications
α-Synuclein emulsifies TDP-43 prion-like domain—RNA liquid droplets to promote heterotypic amyloid fibrils
Published by
Communications Biology
Summary
journal-article
Intermediate Antiparallel β Structure in Amyloid β Plaques Revealed by Infrared Spectroscopic Imaging
Published by
ACS Chemical Neuroscience
Summary
journal-article
Intermediate Antiparallel Fibrils in Aβ40 Dutch Mutant Aggregation: Insights from Nanoscale Infrared Spectroscopy
Published by
The Journal of Physical Chemistry B
Summary
journal-article
β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
Published by
International Journal of Molecular Sciences
Summary
journal-article
β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
Published by
International Journal of Molecular Sciences
Summary
journal-article
Nanoscale Infrared Spectroscopy Identifies Parallel to Antiparallel β-Sheet Transformation of Aβ Fibrils
Published by
The Journal of Physical Chemistry Letters
Summary
journal-article
Nanoscale Infrared Spectroscopy Identifies Structural Heterogeneity in Individual Amyloid Fibrils and Prefibrillar Aggregates
Published by
The Journal of Physical Chemistry B
Summary
journal-article
Structural heterogeneity of amyloid aggregates identified by spatially resolved nanoscale infrared spectroscopy
Summary
preprint
Structurally distinct polymorphs of Tau aggregates revealed by nanoscale infrared spectroscopy
Summary
other
Structurally Distinct Polymorphs of Tau Aggregates Revealed by Nanoscale Infrared Spectroscopy
Published by
The Journal of Physical Chemistry Letters
Summary
journal-article
Structurally Distinct Polymorphs of Tau Aggregates Revealed by Nanoscale Infrared Spectroscopy
Published by
The Journal of Physical Chemistry Letters
Summary
journal-article
Cholesterol in Membranes Facilitates Aggregation of Amyloid β Protein at Physiologically Relevant Concentrations
Published by
ACS Chemical Neuroscience
Summary
journal-article
Topographically smooth and stable supported lipid bilayer for high-resolution AFM studies
Published by
Methods
Summary
journal-article
Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers
Published by
International Journal of Molecular Sciences
Summary
journal-article
Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers
Published by
International Journal of Molecular Sciences
Summary
journal-article
Molecular Model for the Surface-Catalyzed Protein Self-Assembly.
Published by
The journal of physical chemistry. B
Summary
journal-article
Assembly of α-synuclein aggregates on phospholipid bilayers
Published by
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Summary
journal-article
Interaction of Amyloidogenic Proteins with Membranes and Molecular Mechanism for the Development of Alzheimer’s disease
Summary
journal-article
Nanoscale Dynamics of Amyloid β-42 Oligomers As Revealed by High-Speed Atomic Force Microscopy
Published by
ACS Nano
Summary
journal-article
Nanoscale dynamics of centromere nucleosomes and the critical roles of CENP-A
Published by
Nucleic Acids Research
Summary
journal-article
A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces
Published by
Scientific Reports
Summary
journal-article
Nanoscale On-Silico Electron Transport via Ferritins
Published by
Langmuir
Summary
journal-article
Discriminating Intercalative Effects of Threading Intercalator Nogalamycin, from Classical Intercalator Daunomycin, Using Single Molecule Atomic Force Spectroscopy
Published by
PLOS ONE
Summary
journal-article
Molecularly resolved label-free sensing of single nucleobase mismatches by interfacial LNA probes
Published by
Nucleic Acids Research
Summary
journal-article
Interactions of Histone Acetyltransferase p300 with the Nuclear Proteins Histone and HMGB1, As Revealed by Single Molecule Atomic Force Spectroscopy
Published by
The Journal of Physical Chemistry B
Summary
journal-article
Nanoscale Mechano–Electronic Behavior of a Metalloprotein as a Variable of Metal Content
Published by
Langmuir
Summary
journal-article
Structural features of human histone acetyltransferase p300 and its complex with p53
Published by
FEBS Letters
Summary
journal-article
Near-Metallic Behavior of Warm Holoferritin Molecules on a Gold(111) Surface
Published by
Langmuir
Summary
journal-article