Loss of ovarian hormones modulates the nucleic acid content of circulating extracellular vesicles and skeletal muscle metabolism in response to acute exercise
Summary
preprint
Sira Karvinen
About
I am a PhD (exercise physiology) and Docent (molecular physiology) and work currently as an Academy Research Fellow at the Gerontology Research Center at the Faculty of Sport and Health Sciences at the university of Jyväskylä, Finland. I am fascinated to discover the molecular and physiological mechanisms underlying healthy aging and longevity. I run my own research project (EEVaS) concentrating on extracellular vesicles, exercise and aging.
Work
Gerontology Research Center
|Academy Research Fellow
Finland
→
Gerontology Research Center
|Academy of Finland Postdoctoral Researcher
Finland
→
University of Minnesota
|Postdoctoral Researcher
US
→
University of Jyväskylä
|PhD student
Finland
→
Education
University of Jyväskylä
Finland
→
PhD
University of Jyväskylä
Finland
→
M.Sc
Publications
The acute exercise response of peripheral blood mononuclear cells and their bioenergetic function in women with high and low systemic estradiol levels
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Physiological Reports
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Interaction of the C2C12 myotube contractions and glucose availability on transcriptome and extracellular vesicle microRNAs
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American Journal of Physiology-Cell Physiology
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Branched-chain amino acid supplementation and voluntary running have distinct effects on the serum metabolome of rats with high or low intrinsic aerobic capacity
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Frontiers in Nutrition
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Estrogen deficiency reduces maximal running capacity and affects serotonin levels differently in the hippocampus and nucleus accumbens in response to acute exercise
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Extracellular vesicles and high-density lipoproteins: Exercise and estrogen-responsive small RNA carriers
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Journal of Extracellular Vesicles
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Menopausal transition alters female skeletal muscle transcriptome
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Extracellular vesicles and high-density lipoproteins: Exercise and estrogen-responsive small RNA carriers
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Total and regional body adiposity increases during menopause-evidence from a follow-up study.
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Aging cell
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Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes.
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Metabolites
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Metabolic health, menopause, and physical activity—a 4-year follow-up study
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International Journal of Obesity
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Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
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GeroScience
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Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
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GeroScience
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Estradiol deficiency and skeletal muscle apoptosis: Possible contribution of microRNAs
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Experimental Gerontology
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Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering
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International Journal of Environmental Research and Public Health
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MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise
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Frontiers in Physiology
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Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women.
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Journal of clinical medicine
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Beneficial effects of running and milk protein supplements on Sirtuins and risk factors of metabolic disorders in rats with low aerobic capacity
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Metabolism Open
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Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women: Cross-sectional and longitudinal evidence
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Frontiers in Endocrinology
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17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle
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Cell Metabolism
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Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice
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PLoS ONE
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Estrogenic regulation of skeletal muscle proteome: a study of premenopausal women and postmenopausal MZ cotwins discordant for hormonal therapy
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Aging Cell
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Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins
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Experimental Gerontology
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Voluntary running aids to maintain high body temperature in rats bred for high aerobic capacity
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Frontiers in Physiology
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Physical activity in adulthood: Genes and mortality
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Scientific Reports
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Lipid droplet-associated proteins in high-fat fed mice with the effects of voluntary running and diet change
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Metabolism: Clinical and Experimental
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High-fat feeding induces angiogenesis in skeletal muscle and activates angiogenic pathways in capillaries
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Angiogenesis
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Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle
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Nutrition and Metabolism
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Rats Bred for Low Aerobic Capacity Become Promptly Fatigued and Have Slow Metabolic Recovery after Stimulated, Maximal Muscle Contractions
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PLoS ONE
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Effects of diet-induced obesity and voluntary wheel running on the microstructure of the murine distal femur
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Nutrition and Metabolism
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Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine
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Biochemical and Biophysical Research Communications
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Effects of diet-induced obesity and voluntary wheel running on bone properties in young male C57BL/6J mice.
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Calcified tissue international
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