Highly accomplished Ph.D. in Biochemistry and Molecular Biology with over a decade of experience in structural, cell, and molecular biology, specializing in drug discovery and development for cancer, neurological disorders, and diabetes. Expert in protein engineering, high-throughput assays, and analytical characterization, with a proven track record of advancing targeted therapies from lab to clinical application and authoring over 10 peer-reviewed publications.
Los Angeles, CA, US
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Summary
Leading drug discovery and development initiatives, leveraging expertise in structural, cell, and molecular biology to advance oncology and metabolic disorder therapies from preclinical stages to clinical application.
Highlights
Spearhead drug discovery and development efforts for diverse diseases, including cancer and diabetes, integrating structural, cell, and molecular biology approaches.
Evaluated novel small molecules as oncology drug candidates, targeting cancer-related pathways to advance therapeutic pipelines.
Applied advanced protein engineering and a wide variety of biophysics methods, including Biacore SPR, ITC, Fluorescence Polarization, TSA, and NanoBRET, to characterize drug-target interactions.
Utilized cellular and animal model approaches for investigating cancer targets, driving translational development from lab to clinical application.
Los Angeles, CA, US
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Summary
Identified and functionally characterized cancer targets, driving preclinical and clinical development of potential targeted therapeutic approaches with a focus on acute myeloid leukemia.
Highlights
Identified and functionally characterized novel cancer targets, contributing to preclinical and clinical development of targeted therapeutic approaches for acute myeloid leukemia.
Conducted comprehensive cell biology and animal model studies to investigate cancer targets and disease mechanisms.
Performed advanced data analysis to identify key cancer genes, informing therapeutic strategy and target validation.
Dortmund, North Rhine-Westphalia, Germany
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Summary
Investigated novel bioactive small molecule compounds, identifying their molecular targets and mechanisms of action through diverse molecular, cell, biochemical, and biophysical methods.
Highlights
Investigated novel bioactive small molecule compounds, successfully identifying molecular targets and modes of action for drug discovery.
Utilized a wide array of molecular biological, cell biology, high-throughput assays (including cell painting), biochemical, and biophysical methods to characterize compounds.
Managed multiple projects, demonstrating strong self-organization and time management in complex research environments.
Designed and executed experiments on novel cluster investigation using cell painting high-throughput assays, validating findings with diverse cellular and molecular biology methods.
Collaborated effectively within interdisciplinary and multicultural teams to investigate new PROTACs binding to DCAF11.
Mentored and led trainees, PhD, and master students, fostering scientific development and project success.
Presented scientific results internally and externally, contributing to knowledge dissemination and collaborative efforts.
Düsseldorf, North Rhine-Westphalia, Germany
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Summary
Investigated molecular mechanisms and structural properties of signaling pathways relevant to Noonan Syndrome and other diseases, utilizing independent experimental design and advanced biophysical techniques.
Highlights
Investigated molecular mechanisms and structural properties of signaling pathways relevant to Noonan Syndrome and other diseases.
Independently planned, executed, and evaluated complex molecular biological, biochemical, and biophysical experiments (ITC, fluorescence polarization, SPR, stopped-flow).
Designed and conducted Ras GTPase-effector activation mechanism studies, from cloning and purification to biophysical assays and computational analysis.
Purified Kinase proteins from Baculovirus insect cells and performed various biophysical assays including enzymatic assay, ITC, Biacore SPR, and Cryo EM.
Clemson, SC, US
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Summary
Investigated molecular mechanisms and structural properties of proteins using advanced fluorescence techniques, including single molecule FRET, in collaboration with international laboratories.
Highlights
Investigated molecular mechanisms and structural properties of proteins using advanced fluorescence techniques.
Conducted a benchmark study and collaborated with 20 international labs using Single molecule FRET to understand structural properties.
Designed and independently conducted experiments to elucidate the structural properties of diverse biological systems.
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M.S.
Biochemistry and Chemistry
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B.S.
Chemistry
Awarded By
6th International Congress of Biochemistry and Molecular Biology
Awarded for outstanding poster presentation at the 6th International Congress of Biochemistry and Molecular Biology in Isfahan, Iran.
Awarded By
NRW Research School
Received a prestigious scholarship from the European Rare Disease, NRW Research School in Germany.
Awarded By
Clemson University
Recognized as an honor student for academic excellence at Clemson University.
Awarded By
Clemson University
Awarded a scholarship for academic achievement at Clemson University.
Awarded By
Sharif University of Technology
Achieved the top rank among organic chemistry students at Sharif University of Technology in Tehran, Iran.
Awarded By
Forschungszentrum Jülich
Awarded a scholarship as a visiting student at Forschungszentrum Jülich in Germany.
Awarded By
Isfahan University of Technology
Achieved the third rank among Bachelor students in the Chemistry department at Isfahan University of Technology, Iran.
Published by
Journal of Medicinal Chemistry
Summary
Soheila Rezaei Adariani, Daya Agne, Sandra Koska, Annina Burhop, Herbert Waldmann, Slava Zeigler. Journal of Medicinal Chemistry, 67, no. 15 (2024): 13252-13270.
Published by
Journal of Medicinal Chemistry
Summary
Axel Pahl, Jie Liu, Sohan Patil, Soheila Rezaei Adariani, Slava Zeigler, Herbert Waldmann. Journal of Medicinal Chemistry, 67, no. 11 (2024): 8862-8876.
Published by
Journal of Nature Communication
Summary
Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Soheila Rezaei Adariani, Lara Dötsch, Petra Janning, Georg E. Winter, and Herbert Waldmann. Journal of Nature Communication, 14, no. 1 (2023): 7908.
Published by
Cells
Summary
Silke Pudewell, Jana Lissy, Hossein Nakhaeizadeh, Mohamed S. Taha, Mohammad Akbarzadeh, Soheila Rezaei Adariani, Mohammad Reza Ahmadian. Cells, 11, no. 3 (2022): 508.
Published by
Journal of Biological Chemistry
Summary
Soheila Rezaei Adariani, Neda S. Kazemein Jasemi, Christoph Wittch, Ehsan Amin, Claus A.M. Seidel, Radovan Dvorsky, Mohammad R. Ahmadian. Journal of Biological Chemistry, 296 (2021).
Published by
American Journal of Human Genetics
Summary
Capri, Y., Elisabetta Flex, Oliver H. F. Krumbach, Giovanna Carpentieri, Serena Cecchetti, Christina Lißewski, Soheila Rezaei Adariani, Martin Zenker. American Journal of Human Genetics, 104, no. 6 (2019): 1223-1232.
Published by
Journal of Nature Methods
Summary
Hellenkamp, Björn, Sonja Schmid, Olga Doroshenko, Oleg Opanasyuk, Ralf Kühnemuth, Soheila Rezaei Adariani, Thorsten Hugel. Journal of Nature Methods, 15, no. 9 (2018): 669-676.
Published by
Journal of Nature Communications
Summary
Yanez Orozco, Inna S., Frank A. Mindlin, Junyan Ma, Bo Wang, Brie Levesque, Matheu Spencer, Soheila Rezaei Adariani, George Hamilton, Feng Ding, Mark E. Bowen & Hugo Sanabria. Journal of Nature Communications, 9, no. 1 (2018): 3724.
Published by
Biochemical Society Transactions
Summary
Soheila Rezaei Adariani, Marcel Buchholzer, Mohammad Akbarzadeh, Saeideh Nakhaei-Rad, Radovan Dvorsky, Mohammad Reza Ahmadian. Biochemical Society Transactions, 46, no. 6 (2018): 1393-1406.
Published by
Biochemistry and Molecular Biology
Summary
Saeideh Nakhaei-Rad, Fereshteh Haghighi, Parivash Nouri, Soheila Rezaei Adariani, Jana Lissy, Neda S. Kazemein Jasemi, Radovan Dvorsky & Mohammad Reza Ahmadian. Biochemistry and Molecular Biology, 53, no. 2 (2018): 130-156.
Published by
Journal of Biological Chemistry
Summary
Dolino, Drew M.*, Soheila Rezaei Adariani*, Sana A Shaikh, Vasanthi Jayaraman, Hugo Sanabria. Journal of Biological Chemistry, 291, no. 31 (2016): 16175-16185. *equal contribution.
Project Planning, Time Management, Interdisciplinary Collaboration, Team Leadership.
Scientific Presentation, Peer-Reviewed Publications, Data Interpretation, Report Generation.
Mammalian Cell Culture, Plate- and flask-based assay, Blood Sample Preparation, High Throughput Assays, Cell Painting, Transfection/Transduction, Microscopy, Immunofluorescence, Immunoprecipitation, Proteomics, Western Blot, Flow Cytometry, ELISA, Seahorse Cell Mito Stress, Reporter Gene Assay, Analysis of Membrane Potential, MitoSOX Red Assay, Drug Development (Small Molecules & Peptides), Incucyte, Plate Reader.
Animal Handling, Tumor Implantation, Drug Dosing (IP, IV, Oral), Tissue Harvesting, Survival Studies.
Surface Plasmon Resonance (SPR), Biacore, IsoThermal Calorimetry (ITC), Stopped-flow, Fluorescence Spectroscopy, Fluorescence Polarization, FRET, TCSPC, Confocal Microscopy, FCS, Single Molecule Detection, NanoBRET, Hamilton Liquid Handler.
RNA/DNA Isolation, Site-Directed Mutation, Cloning, RT-PCR, qPCR, PCR.
Cloning, Expression (E Coli, mammalian cell, Insect Cell), Chromatography Purification (FPLC, AKTA & NGC), Analytical HPLC, SDS Page, Western Blot, Enzymatic Kinetic Assay, Bioconjugation (Click Chemistry & Crosslinkers).
R, Pymol, Figi, Clone Manager, Bioedit, Snap Gene, CorelDraw, Illustrator, CellProfiller, Grafit, Endnote, Structure Modeling, Biological Data Mining and Analysis, GraphPad Prism, Maestro Schrödinger, Ms-Office.