Soumya Mukherjee

About

I am an Assistant Professor in the Department of Neurology at Washington University. I obtained my PhD in Chemistry from the University of Calcutta and specialize in proteomics and mass spectrometry. My current research interests are in understanding the molecular mechanisms in neurodegeneration and the role protein post-translational modifications (PTMs) has to play during disease progression. Specifically I am interested in the 1) cross-talk of PTMs during disease staging, 2) protein aging and 3) altered proteoforms in neurodegenerative diseases. My goals are in translation of these findings using analytical techniques for the development of disease biomarkers.

Work

Washington University at St Louis School of Medicine

Assistant Professor

Jan 2024

→

Present

Washington University in St Louis School of Medicine

Research Instructor

Aug 2022

→

Dec 2023

Utrecht University

Postdoctoral Researcher

Netherlands

Jan 2021

→

Mar 2022

Florey Institute of Neuroscience and Mental Health

Postdoctoral Researcher

Australia

Jul 2017

→

Dec 2020

Education

Indian Association for the Cultivation of Science

India

Jul 2017

→

Dec 2020

Ph.D.

Publications

Post-translational modifications distinguish amyloid-β isoform patterns extracted from vascular deposits and parenchymal plaques

Jan 2025

Summary

preprint

Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s Disease spectrum

Jan 2025

Summary

preprint

Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s disease spectrum

Jan 2025

Published by

Acta Neuropathologica

Summary

journal-article

Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer's disease spectrum.

Jan 2025

Published by

Acta neuropathologica

Summary

journal-article

Quantitative proteomics of tau and Aβ in n detergent fractions from Alzheimer's disease brains

Jan 2023

Published by

Journal of Neurochemistry

Summary

journal-article

Oxonium Ion–Guided Optimization of Ion Mobility–Assisted Glycoproteomics on the timsTOF Pro

Jan 2023

Published by

Molecular and Cellular Proteomics

Summary

journal-article

Oxonium Ion-Guided Optimization of Ion Mobility-Assisted Glycoproteomics on the timsTOF Pro

Jan 2023

Published by

Molecular & Cellular Proteomics

Summary

journal-article

Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains

Jan 2023

Published by

Journal of Neurochemistry

Summary

journal-article

Oxonium Ion–Guided Optimization of Ion Mobility–Assisted Glycoproteomics on the timsTOF Pro

Jan 2023

Published by

Molecular & Cellular Proteomics

Summary

journal-article

Enhanced ion mobility resolution of Abeta isomers from human brain using high-resolution demultiplexing software

Jan 2022

Published by

Analytical and Bioanalytical Chemistry

Summary

journal-article

Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains

Jan 2022

Published by

Journal of Neurochemistry

Summary

journal-article

Enhanced ion mobility resolution of Abeta isomers from human brain using high-resolution demultiplexing software

Jan 2022

Published by

Analytical and Bioanalytical Chemistry

Summary

journal-article

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease

Jan 2021

Published by

Brain Communications

Summary

journal-article

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease

Jan 2021

Published by

Brain Communications

Summary

journal-article

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer's disease

Jan 2021

Published by

Brain Communications

Summary

journal-article

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer's disease

Jan 2021

Published by

Brain Communications

Summary

journal-article

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

Jan 2021

Published by

Frontiers in Immunology

Summary

journal-article

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

Jan 2021

Published by

Frontiers in Immunology

Summary

journal-article

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

Jan 2021

Published by

Frontiers in Immunology

Summary

journal-article

Citrullination of Amyloid-β Peptides in Alzheimer’s Disease

Jan 2021

Published by

ACS Chemical Neuroscience

Summary

journal-article

Citrullination of Amyloid-β Peptides in Alzheimer’s Disease

Jan 2021

Published by

ACS Chemical Neuroscience

Summary

journal-article

Citrullination of Amyloid-β Peptides in Alzheimer's Disease

Jan 2021

Published by

ACS Chemical Neuroscience

Summary

journal-article

Citrullination of Amyloid-β Peptides in Alzheimer's Disease

Jan 2021

Published by

ACS Chemical Neuroscience

Summary

journal-article

Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

Jan 2021

Published by

Medicine in Drug Discovery

Summary

journal-article

Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

Jan 2021

Published by

Medicine in Drug Discovery

Summary

journal-article

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Jan 2019

Published by

Metallomics

Summary

journal-article

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Jan 2019

Published by

Analytical Chemistry

Summary

journal-article

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Jan 2019

Published by

Analytical Chemistry

Summary

journal-article

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Jan 2019

Published by

Analytical Chemistry

Summary

journal-article

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Jan 2019

Published by

Metallomics

Summary

journal-article

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Jan 2018

Published by

Metallomics

Summary

journal-article

Copper induced spin state change of heme–Aβ associated with Alzheimer's disease

Jan 2017

Published by

Dalton Transactions

Summary

journal-article

Copper induced spin state change of heme-Aβ associated with Alzheimer's disease

Jan 2017

Published by

Dalton Transactions

Summary

journal-article

Copper induced spin state change of heme–Aβ associated with Alzheimer's disease Dalton Transactions

Jan 2017

Published by

Dalton Transaction

Summary

journal-article

Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL)

Jan 2017

Published by

Journal of Alzheimer's Disease

Summary

journal-article

Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL)

Jan 2017

Published by

Journal of Alzheimer's Disease

Summary

journal-article

Characterization and identification of dityrosine crosslinked peptides using tandem mass spectrometry

Jan 2017

Published by

Analytical Chemistry

Summary

journal-article

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Jan 2017

Published by

Analytical Chemistry

Summary

journal-article

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Jan 2017

Published by

Analytical Chemistry

Summary

journal-article

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Jan 2017

Published by

Analytical Chemistry

Summary

journal-article

Fe–oxy adducts of heme–Aβ and heme–hIAPP complexes: intermediates in ROS generation

Jan 2016

Published by

Metallomics

Summary

journal-article

Peroxidase to Cytochrome b Type Transition in the Active Site of Heme-Bound Amyloid β Peptides Relevant to Alzheimer’s Disease

Jan 2016

Published by

Inorganic chemistry

Summary

journal-article

Peroxidase to Cytochrome b Type Transition in the Active Site of Heme-Bound Amyloid β Peptides Relevant to Alzheimer's Disease

Jan 2016

Published by

Inorganic Chemistry

Summary

journal-article

Fe-oxy adducts of heme-Aβ and heme-hIAPP complexes: Intermediates in ROS generation

Jan 2016

Published by

Metallomics

Summary

journal-article

Alzheimer's Disease: A Heme-Aβ Perspective

Jan 2015

Published by

Accounts of Chemical Research

Summary

journal-article

Alzheimer’s Disease: A Heme–Aβ Perspective

Jan 2015

Published by

Accounts of chemical research

Summary

journal-article

Alzheimer's Disease: A Heme-Aβ Perspective

Jan 2015

Published by

Accounts of Chemical Research

Summary

journal-article

Kinetics of serotonin oxidation by heme–Aβ relevant to Alzheimer’s disease

Jan 2014

Published by

JBIC Journal of Biological Inorganic Chemistry

Summary

journal-article

Heme bound amylin self-assembled monolayers on an Au electrode: An efficient bio-electrode for O<sub>2</sub> reduction to H<sub>2</sub>O

Jan 2014

Published by

Chemical Communications

Summary

journal-article

Kinetics of serotonin oxidation by heme-Aβ relevant to Alzheimer's disease

Jan 2014

Published by

Journal of Biological Inorganic Chemistry

Summary

journal-article

Kinetics of serotonin oxidation by heme-Aβ relevant to Alzheimer's disease

Jan 2014

Published by

Journal of Biological Inorganic Chemistry

Summary

journal-article

Analogues of oxy-heme Aβ: Reactive intermediates relevant to Alzheimer’s disease

Jan 2013

Published by

Chemical Communications

Summary

journal-article

Apomyoglobin Sequesters Heme from Heme Bound Aβ Peptides

Jan 2013

Published by

Inorganic Chemistry

Summary

journal-article

Apomyoglobin sequesters heme from heme bound Aβ peptides

Jan 2013

Published by

Inorganic Chemistry

Summary

journal-article

Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease

Jan 2013

Published by

Chemical Communications

Summary

journal-article

Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer’s disease

Jan 2013

Published by

Chemical Communications

Summary

journal-article

Heme Bound Amylin: Spectroscopic Characterization, Reactivity, and Relevance to Type 2 Diabetes

Jan 2013

Published by

Inorganic Chemistry

Summary

journal-article

Interaction of NO with Cu and Heme-Bound Aβ Peptides Associated with Alzheimer’s Disease

Jan 2013

Published by

Inorganic Chemistry

Summary

journal-article

Interaction of NO with Cu and heme-bound Aβ peptides associated with Alzheimer's disease

Jan 2013

Published by

Inorganic Chemistry

Summary

journal-article

Interaction of amyloid β peptides with redox active heme cofactor: Relevance to Alzheimer's disease

Jan 2013

Published by

Coordination Chemistry Reviews

Summary

journal-article

Interaction of amyloid β peptides with redox active heme cofactor: Relevance to Alzheimer's disease

Jan 2013

Published by

Coordination Chemistry Reviews

Summary

journal-article

Heme bound amylin: Spectroscopic characterization, reactivity, and relevance to type 2 diabetes

Jan 2013

Published by

Inorganic Chemistry

Summary

journal-article

Self-assembled monolayers of Aβ peptides on Au electrodes: An artificial platform for probing the reactivity of redox active metals and cofactors relevant to Alzheimer's disease

Jan 2012

Published by

Journal of the American Chemical Society

Summary

journal-article

Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease

Jan 2012

Published by

Chemical Communications

Summary

journal-article

Self-assembled monolayers of Aβ peptides on au electrodes: An artificial platform for probing the reactivity of redox active metals and cofactors relevant to Alzheimer’s disease

Jan 2012

Published by

Journal of the American Chemical Society

Summary

journal-article

Soumya Mukherjee

About

Work

Washington University at St Louis School of Medicine

Washington University in St Louis School of Medicine

Utrecht University

Florey Institute of Neuroscience and Mental Health

Education

Indian Association for the Cultivation of Science

Publications

Post-translational modifications distinguish amyloid-β isoform patterns extracted from vascular deposits and parenchymal plaques

Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s Disease spectrum

Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s disease spectrum

Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer's disease spectrum.

Quantitative proteomics of tau and Aβ in n detergent fractions from Alzheimer's disease brains

Oxonium Ion–Guided Optimization of Ion Mobility–Assisted Glycoproteomics on the timsTOF Pro

Oxonium Ion-Guided Optimization of Ion Mobility-Assisted Glycoproteomics on the timsTOF Pro

Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains

Oxonium Ion–Guided Optimization of Ion Mobility–Assisted Glycoproteomics on the timsTOF Pro

Enhanced ion mobility resolution of Abeta isomers from human brain using high-resolution demultiplexing software

Quantitative proteomics of tau and Aβ in detergent fractions from Alzheimer's disease brains

Enhanced ion mobility resolution of Abeta isomers from human brain using high-resolution demultiplexing software

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer's disease

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer's disease

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

Citrullination of Amyloid-β Peptides in Alzheimer’s Disease

Citrullination of Amyloid-β Peptides in Alzheimer’s Disease

Citrullination of Amyloid-β Peptides in Alzheimer's Disease

Citrullination of Amyloid-β Peptides in Alzheimer's Disease

Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Copper induced spin state change of heme–Aβ associated with Alzheimer's disease

Copper induced spin state change of heme-Aβ associated with Alzheimer's disease

Copper induced spin state change of heme–Aβ associated with Alzheimer's disease Dalton Transactions

Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL)

Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker &amp; Lifestyle Flagship Study of Ageing (AIBL)

Characterization and identification of dityrosine crosslinked peptides using tandem mass spectrometry

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Fe–oxy adducts of heme–Aβ and heme–hIAPP complexes: intermediates in ROS generation

Peroxidase to Cytochrome b Type Transition in the Active Site of Heme-Bound Amyloid β Peptides Relevant to Alzheimer’s Disease

Peroxidase to Cytochrome b Type Transition in the Active Site of Heme-Bound Amyloid β Peptides Relevant to Alzheimer's Disease

Fe-oxy adducts of heme-Aβ and heme-hIAPP complexes: Intermediates in ROS generation

Alzheimer's Disease: A Heme-Aβ Perspective

Alzheimer’s Disease: A Heme–Aβ Perspective

Alzheimer's Disease: A Heme-Aβ Perspective

Kinetics of serotonin oxidation by heme–Aβ relevant to Alzheimer’s disease

Heme bound amylin self-assembled monolayers on an Au electrode: An efficient bio-electrode for O<sub>2</sub> reduction to H<sub>2</sub>O

Kinetics of serotonin oxidation by heme-Aβ relevant to Alzheimer's disease

Kinetics of serotonin oxidation by heme-Aβ relevant to Alzheimer's disease

Analogues of oxy-heme Aβ: Reactive intermediates relevant to Alzheimer’s disease

Apomyoglobin Sequesters Heme from Heme Bound Aβ Peptides

Apomyoglobin sequesters heme from heme bound Aβ peptides

Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease

Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer’s disease

Heme Bound Amylin: Spectroscopic Characterization, Reactivity, and Relevance to Type 2 Diabetes

Interaction of NO with Cu and Heme-Bound Aβ Peptides Associated with Alzheimer’s Disease

Interaction of NO with Cu and heme-bound Aβ peptides associated with Alzheimer's disease

Interaction of amyloid β peptides with redox active heme cofactor: Relevance to Alzheimer's disease

Interaction of amyloid β peptides with redox active heme cofactor: Relevance to Alzheimer's disease

Heme bound amylin: Spectroscopic characterization, reactivity, and relevance to type 2 diabetes

Self-assembled monolayers of Aβ peptides on Au electrodes: An artificial platform for probing the reactivity of redox active metals and cofactors relevant to Alzheimer's disease

Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease

Self-assembled monolayers of Aβ peptides on au electrodes: An artificial platform for probing the reactivity of redox active metals and cofactors relevant to Alzheimer’s disease

Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL)