Susanna Hofmann

Publications

Sex-Specific Restoration of CD4+ T-Cell Receptor Activity Through Exercise Training in Patients Undergoing Hemodialysis

Summary

preprint

NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.

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The EMBO journal

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journal-article

Geschlechtersensible Aspekte von Diabetes mellitus Typ 2

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Die Diabetologie

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Leitbilder und Forschung in der Geschlechtersensiblen Medizin

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Zeitschrift für medizinische Ethik

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Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

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Molecular Metabolism

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Non-invasive optoacoustic imaging visualizes exercise-induced dermal revascularization in obese mice

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preprint

Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration

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Cell Metabolism

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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

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Nature Metabolism

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Fasting‐sensitive SUMO‐switch on Prox1 controls hepatic cholesterol metabolism

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EMBO reports

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GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease

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Cardiovascular Diabetology

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Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response

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Diabetologia

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Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome

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Molecular Metabolism

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GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

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Nature Metabolism

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GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

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Nature Metabolism

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Research in metabolic ageing — a tale of mice versus humans?

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Nature Reviews Endocrinology

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Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice.

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EMBO molecular medicine

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The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.

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Cell metabolism

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Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice.

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Diabetes, obesity & metabolism

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Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission.

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Nature metabolism

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Targeted pharmacological therapy restores β-cell function for diabetes remission.

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Nature metabolism

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Corrigendum to “Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase” (Molecular Metabolism (2018) 7 (155–160), (S2212877817307391) (10.1016/j.molmet.2017.11.003))

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Molecular Metabolism

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Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

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Nature Reviews Endocrinology

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Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

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Cell Metabolism

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Glucagon regulation of energy expenditure

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International Journal of Molecular Sciences

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Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans

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American journal of physiology. Endocrinology and metabolism

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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease

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Molecular Systems Biology

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Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin

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Molecular Metabolism

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A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue

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International Journal of Obesity

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Animal models of obesity and diabetes mellitus

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Nature Reviews Endocrinology

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Circulating HDL levels control hypothalamic astrogliosis via apoA-I

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Journal of Lipid Research

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Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

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Nature Communications

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Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase

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Molecular Metabolism

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Erratum to: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes (Nature Communications, (2018), 9, 1, (4304), 10.1038/s41467-018-06769-y)

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Nature Communications

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Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs

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Molecular Metabolism

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Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells

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Molecular and Cellular Endocrinology

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Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors

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Molecular Metabolism

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Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance

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EBioMedicine

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Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

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Cell Metabolism

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Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

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Molecular Metabolism

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Sex in basic research: Concepts in the cardiovascular field

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Cardiovascular Research

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Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity

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Cell Reports

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High density lipoprotein and metabolic disease: Potential benefits of restoring its functional properties

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Molecular Metabolism

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Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

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Cell

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The good, the bad, and the unknown: Fructose and FGF21

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Molecular Metabolism

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Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice

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EMBO Molecular Medicine

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Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions

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FASEB Journal

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GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet

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Diabetes

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Fibroblast growth factor 21 mediates specific glucagon actions

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Diabetes

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High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice

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Circulation

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P62 Links β-adrenergic input to mitochondrial function and thermogenesis

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Journal of Clinical Investigation

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The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

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Nature Communications

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The role of ghrelin-octanoyl-acyl-transferase in thermoregulation

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Journal of Endocrinological Investigation

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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

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Science Translational Medicine

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Emerging Function of Fat Mass and Obesity-Associated Protein (Fto)

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PLoS Genetics

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Caloric restriction chronically impairs metabolic programming in mice

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Diabetes

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Exercise protects against high-fat diet-induced hypothalamic inflammation

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Physiology and Behavior

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High-fat-diet exposure induces IgG accumulation in hypothalamic microglia

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DMM Disease Models and Mechanisms

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Pharmacological treatment of obesity

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Sleep Loss and Obesity: Intersecting Epidemics

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book-chapter

Acylation type determines Ghrelin's effects on energy homeostasis in rodents

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Endocrinology

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CNS regulation of plasma cholesterol

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Annals of Medicine

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Hepatic deficiency of low density lipoprotein receptorrelated protein-1 reduces high density lipoprotein secretion and plasma levels in mice

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Journal of Biological Chemistry

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High density lipoprotein: It's not just about lipid transport anymore

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Trends in Endocrinology and Metabolism

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Neural regulation of cholesterol metabolism

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Current Opinion in Lipidology

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Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion

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Gastroenterology

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Ghrelin receptor deficiency does not affect diet-induced atherosclerosis in low-density lipoprotein receptor-null mice

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Frontiers in Endocrinology

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Melanocortin signaling in the CNS directly regulates circulating cholesterol

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Nature Neuroscience

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PKCζ-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance

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Cell Metabolism

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Lack of association between adiponectin levels and atherosclerosis in mice

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Arteriosclerosis, Thrombosis, and Vascular Biology

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Dietary sugars: A fat difference

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Journal of Clinical Investigation

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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

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Nature Chemical Biology

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Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice

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Diabetes

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Obesity-associated improvements in metabolic profile through expansion of adipose tissue

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Journal of Clinical Investigation

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The central melanocortin system directly controls peripheral lipid metabolism

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Journal of Clinical Investigation

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Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice

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Journal of Clinical Investigation

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Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries

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Circulation

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The tumour necrosis factor-alpha induced vascular permeability is associated with a reduction of VE-cadherin expression.

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European journal of medical research

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Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C→T:A mutations

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Human Molecular Genetics

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Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse

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Diabetes

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Endothelin-1 Stimulates Steroid Secretion of Human Adrenocortical Cells ex Vivo Via Both ETA and ETB Receptor Subtypes

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The Journal of Clinical Endocrinology & Metabolism

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Susanna Hofmann