Tao Liu

Work

Peking University
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Professor/PI

China

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California Institute for Biomedical Research
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Scientist

US

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The Scripps Research Institute
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Postdoc

US

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Education

The Ohio State University
United States of America

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Ph.D.

Nankai University
China

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B.S.

Publications

Small Molecule Drugs Triggered the Activation of Macrocycle Masked Proteins

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Nano Letters

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Genetic Code Expansion: Recent Developments and Emerging Applications

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Chemical Reviews

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Design and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid

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Nature Communications

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A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo

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Journal of the American Chemical Society

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Designing artificial fluorescent proteins and biosensors by genetically encoding molecular rotor-based amino acids

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Nature Chemistry

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Computation-Guided Discovery of Diazole Monosubstituted Tetrazines as Optimal Bioorthogonal Tools

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Journal of the American Chemical Society

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Site-specific incorporation of reduction-controlled guest amino acids into proteins for cucurbituril recognition

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Chinese Chemical Letters

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Tracking endogenous proteins based on RNA editing-mediated genetic code expansion

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Nature Chemical Biology

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Studying Reversible Protein Post‐translational Modification through Co‐translational Modification

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ChemBioChem

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In memory of Professor Wei Jiang, a rising star in supramolecular chemistry

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Chem

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Reversible control of tetrazine bioorthogonal reactivity by naphthotube-mediated host-guest recognition

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Chem

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Recent Advances in Genetic Code Expansion: From Cell Engineering to Protein Design

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Journal of Molecular Biology

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Innovative CRISPR Screening Promotes Drug Target Identification

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ACS Central Science

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Creation of a Yeast Strain with Co‐Translationally Acylated Nucleosomes

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Angewandte Chemie International Edition

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Efficient generation of locus-specific human CAR-T cells with CRISPR/cCas12a

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STAR Protocols

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Genetic-code-expanded cell-based therapy for treating diabetes in mice

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Nature Chemical Biology

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Genetic-code-expanded cell-based therapy for treating diabetes in mice

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Nature Chemical Biology

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Recent Advances in Genetic Code Expansion Techniques for Protein Phosphorylation Studies

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Journal of Molecular Biology

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Efficient generation of locus-specific human CAR-T cells with CRISPR/cCas12a

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STAR Protocols

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A General Supramolecular Approach to Regulate Protein Functions by Cucurbit[7]uril and Unnatural Amino Acid Recognition

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Angewandte Chemie - International Edition

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Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

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Nature Chemical Biology

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Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

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Nature Chemical Biology

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Recent Advances in Genetic Code Expansion Techniques for Protein Phosphorylation Studies

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Journal of Molecular Biology

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Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates

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Molecular Cell

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Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates

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Molecular Cell

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When Supramolecular Chemistry Meets Chemical Biology: New Strategies to Target Proteins through Host‐Guest Interactions

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ChemBioChem

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When Supramolecular Chemistry Meets Chemical Biology: New Strategies to Target Proteins through Host-Guest Interactions

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ChemBioChem

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A General Supramolecular Approach to Regulate Protein Functions by Cucurbit[7]uril and Unnatural Amino Acid Recognition

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Angewandte Chemie International Edition

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A General Supramolecular Approach to Regulate Protein Functions by Cucurbit[7]uril and Unnatural Amino Acid Recognition

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Angewandte Chemie

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Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols.

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Angewandte Chemie (International ed. in English)

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Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols

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Angewandte Chemie - International Edition

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Optical Control of a CRISPR/Cas9 System for Gene Editing by Using Photolabile crRNA

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Angewandte Chemie International Edition

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Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases

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Signal Transduction and Targeted Therapy

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Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases

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Signal Transduction and Targeted Therapy

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Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates

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Science Advances

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Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates

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Science Advances

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An Orthogonal Tyrosyl-tRNA Synthetase/tRNA Pair from a Thermophilic Bacterium for an Expanded Eukaryotic Genetic Code

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Biochemistry

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An Orthogonal Tyrosyl-tRNA Synthetase/tRNA Pair from a Thermophilic Bacterium for an Expanded Eukaryotic Genetic Code

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Biochemistry

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Site-specific protein modification by genetic encoded disulfide compatible thiols

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Chinese Chemical Letters

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Site-specific protein modification by genetic encoded disulfide compatible thiols

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Chinese Chemical Letters

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Efficient Selection Scheme for Incorporating Noncanonical Amino Acids Into Proteins in Saccharomyces cerevisiae

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Frontiers in Bioengineering and Biotechnology

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Rational design of minimum CRISPR guide RNA by site-specific Cas9–RNA conjugation

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Chemical Communications

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Rational design of minimum CRISPR guide RNA by site-specific Cas9-RNA conjugation

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Chemical Communications

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Thermophilic Pyrrolysyl-tRNA Synthetase Mutants for Enhanced Mammalian Genetic Code Expansion

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ACS Synthetic Biology

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Therapeutic applications of genetic code expansion

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Synthetic and Systems Biotechnology

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Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids

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Journal of the American Chemical Society

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Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids

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Journal of the American Chemical Society

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Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors

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Journal of the American Chemical Society

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Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors

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Journal of the American Chemical Society

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Therapeutic applications of genetic code expansion

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Synthetic and Systems Biotechnology

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Therapeutic applications of genetic code expansion,基因密码子扩展技术在生物医药领域的应用

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Scientia Sinica Chimica

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Construction and Screening of a Lentiviral Secretome Library

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Cell Chemical Biology

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Construction and Screening of a Lentiviral Secretome Library

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Cell Chemical Biology

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Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria

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Nature Chemical Biology

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Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria

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Nature Chemical Biology

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Enhancing protein stability with extended disulfide bonds

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Proceedings of the National Academy of Sciences of the United States of America

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Enhancing protein stability with extended disulfide bonds

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Proceedings of the National Academy of Sciences of the United States of America

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Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones

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Acs Chemical Biology

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Rational design of dual agonist-antibody fusions as long-acting therapeutic hormones

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ACS Chemical Biology

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Recombinant thiopeptides containing noncanonical amino acids

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Proceedings of the National Academy of Sciences of the United States of America

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Recombinant thiopeptides containing noncanonical amino acids

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Proceedings of the National Academy of Sciences of the United States of America

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Homogeneously modified immunoglobulin domains for therapeutic application

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Current Opinion in Chemical Biology

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Homogeneously modified immunoglobulin domains for therapeutic application

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Current Opinion in Chemical Biology

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Homogeneously modified immunoglobulin domains for therapeutic application

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Current Opinion in Chemical Biology

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An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold

Published by

Angewandte Chemie-International Edition

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An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold

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Angewandte Chemie - International Edition

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An Immunosuppressive Antibody-Drug Conjugate

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Journal of the American Chemical Society

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An immunosuppressive antibody-drug conjugate

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Journal of the American Chemical Society

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Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists

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Proceedings of the National Academy of Sciences of the United States of America

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Genetic Incorporation of epsilon-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones

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Acs Chemical Biology

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Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones

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ACS Chemical Biology

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Rational Design of Antibody Protease Inhibitors

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Journal of the American Chemical Society

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Rational design of antibody protease inhibitors

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Journal of the American Chemical Society

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F1000Prime Recommendation

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other

Rational Design of CXCR4 Specific Antibodies with Elongated CDRs

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Journal of the American Chemical Society

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Rational design of CXCR4 specific antibodies with elongated CDRs

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Journal of the American Chemical Society

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Structure-Based Optimization of a Peptidyl Inhibitor against Calcineurin-Nuclear Factor of Activated T Cell (NFAT) Interaction

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Journal of Medicinal Chemistry

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Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction

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Journal of Medicinal Chemistry

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Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs

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Acs Chemical Biology

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Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs

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ACS Chemical Biology

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Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction

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Acs Chemical Biology

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Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction

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ACS Chemical Biology

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High-Throughput Screening of One-Bead-One-Compound Libraries: Identification of Cyclic Peptidyl Inhibitors against Calcineurin/NFAT Interaction

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Acs Combinatorial Science

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High-throughput screening of one-bead-one-compound libraries: Identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction

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ACS Combinatorial Science

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Discovery of cyclic peptides that bind HIV-1 capsid

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Abstracts of Papers of the American Chemical Society

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Discovery of cyclic peptides that bind HIV-1 capsid

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Abstracts of Papers of the American Chemical Society

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High throughput screening of cyclic peptides library to identify inhibitors against calcineurin/NFAT interaction

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Abstracts of Papers of the American Chemical Society

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High throughput screening of cyclic peptides library to identify inhibitors against calcineurin/NFAT interaction

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Abstracts of Papers of the American Chemical Society

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Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1

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Journal of Medicinal Chemistry

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Membrane permeable cyclic peptidyl inhibitors against human peptidylprolyl isomer ase pin1

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Journal of Medicinal Chemistry

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IDENTIFICATION OF POTENT CYCLIC PEPTIDYL PIN1 INHIBITORS FROM A COMBINATORIAL LIBRARY

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Biopolymers

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IDENTIFICATION OF POTENT CYCLIC PEPTIDYL PIN1 INHIBITORS FROM A COMBINATORIAL LIBRARY

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Biopolymers

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Synthesis and screening of a cyclic peptide library: Discovery of small-molecule ligands against human prolactin receptor

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Bioorganic & Medicinal Chemistry

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Synthesis and screening of a cyclic peptide library: Discovery of small-molecule ligands against human prolactin receptor

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Bioorganic and Medicinal Chemistry

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Non-viral gene delivery carrier of probe type host molecule - Interactions between DNA and beta-cyclodextrin derivative complexes (I)

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Chinese Science Bulletin

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Molecular binding behavior of pyridine-2,6-dicarboxamide-bridged bis(beta-cyclodextrin) with oligopeptides: Switchable molecular binding mode

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Bioconjugate Chemistry

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