Wei Hsu

About

Research Program: Morphogenetic Signaling Network in Development and Disease The long-standing interest of my lab is to elucidate the mechanisms that support embryonic morphogenesis, tissue homeostasis, disease pathogenesis, and organ repair and regeneration. Focusing initially on Wnt as one of the most prevalent signaling pathways in developmental biology, we investigate how Wnt signaling and its crosstalk with other pathways control pluripotency, fate specification, and differentiation in stem cells and homeostasis in mature cells. We have recently studied epigenetics, post-translational modification, ciliogenesis, mitochondrial regulation, nucleoskeleton-cytoskeleton, and cross-tissue interaction, causally linked to human diseases. Current projects focus on craniofacial and skeletal development, congenital birth defects and aging diseases, and tissue regeneration. We aim to use this basic knowledge to develop innovative disease prevention and therapy.

Work

Harvard University
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Professor

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Harvard Stem Cell Institute
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Affiliate Faculty

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The Forsyth Institute
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Senior Member of Staff

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Harvard University
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Member of Faculty of Medicine

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University of Rochester School of Medicine and Dentistry
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Dean's Professor

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Columbia University College of Physicians and Surgeons
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Associate Research Scientist/Research Assistant Professor

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Education

Columbia University College of Physicians and Surgeons
United States of America

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Postdoctoral Fellow

Icahn School of Medicine at Mount Sinai
United States of America

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Ph.D.

Publications

SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis

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Communications Biology

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Analysis of skeletal stem cells by renal capsule transplantation and ex vivo culture systems

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Frontiers in Physiology

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miRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling

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eLife

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Determining Bone-forming Ability and Frequency of Skeletal Stem Cells by Kidney Capsule Transplantation and Limiting Dilution Assay

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BIO-PROTOCOL

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Skeletal Stem Cell Isolation from Cranial Suture Mesenchyme and Maintenance of Stemness in Culture

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BIO-PROTOCOL

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SENP2 restrains the generation of pathogenic Th17 cells in inflammatory bowel disease

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preprint

GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis

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Science Advances

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Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.

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Proceedings of the National Academy of Sciences of the United States of America

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Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.

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Development (Cambridge, England)

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journal-article

MicroRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling

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preprint

BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis

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Science Translational Medicine

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The function of Wls in ovarian development.

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Molecular and cellular endocrinology

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The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development

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Developmental Dynamics

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Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models.

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Biochemical and biophysical research communications

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Motoneuron Wnts regulate neuromuscular junction development.

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eLife

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Rap1b is an effector of Axin2 regulating crosstalk of signaling pathways during skeletal development

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Journal of Bone and Mineral Research

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Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis.

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Developmental dynamics : an official publication of the American Association of Anatomists

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Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development

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Scientific Reports

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Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration

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Nature Communications

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Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.

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Development (Cambridge, England)

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BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway

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Osteoarthritis and Cartilage

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BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway

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Osteoarthritis and Cartilage

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BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin

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PLoS Genetics

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CDC42 inhibition suppresses progression of incipient intestinal tumors

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Cancer Research

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Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration

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PLoS Genetics

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Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice

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Bone

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Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis

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Journal of Investigative Dermatology

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Gpr177 Deficiency Impairs Mammary Development and Prohibits Wnt-Induced Tumorigenesis

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PLoS ONE

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Gpr177 regulates pulmonary vasculature development

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Development (Cambridge)

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Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development

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Journal of Bone and Mineral Research

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Intra-epithelial requirement of canonical Wnt signaling for tooth morphogenesis

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Journal of Biological Chemistry

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Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice

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Journal of Biological Chemistry

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Axin1 prevents salmonella invasiveness and inflammatory response in intestinal epithelial cells

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PLoS ONE

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Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

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Journal of Bone and Mineral Research

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Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress

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Diabetes

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Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development

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Developmental Dynamics

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SUMO-specific protease 2 in Mdm2-mediated regulation of p53

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Cell Death and Differentiation

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The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus

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Developmental Biology

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Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis

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Developmental Dynamics

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Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis

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Developmental Dynamics

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Derivation of mouse Trophoblast stem cells from Blastocysts

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Journal of Visualized Experiments

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Derivation of mouse trophoblast stem cells from blastocysts.

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Journal of visualized experiments : JoVE

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Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells

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Developmental Dynamics

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Science signaling podcast: 25 May 2010

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Science Signaling

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The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development

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Science Signaling

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Β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis

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BMC Developmental Biology

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Axin2 controls bone remodeling through the β-catenin-BMP signaling pathway in adult mice

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Journal of Cell Science

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Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

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Proceedings of the National Academy of Sciences of the United States of America

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Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

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Proceedings of the National Academy of Sciences of the United States of America

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Co-opted JNK/SAPK signaling in Wnt/β-catenin-induced tumorgenesis

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Neoplasia

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SUMO-specific protease 2 is essential for modulating p53-mdm2 in development of trophoblast stem cell niches and lineages

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PLoS Biology

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Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of β-catenin in proliferation and differentiation

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Developmental Biology

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Impaired neural development caused by inducible expression of Axin in transgenic mice

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Mechanisms of Development

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Development of a unique system for spatiotemporal and lineage-specific gene expression in mice

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Proceedings of the National Academy of Sciences of the United States of America

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The role of Axin2 in calvarial morphogenesis and craniosynostosis

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Development

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Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice

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Journal of Cell Biology

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Domains of Axin and Disheveled required for interaction and function in Wnt signaling

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Biochemical and Biophysical Research Communications

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Identification of a domain of axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

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Journal of Biological Chemistry

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The mouse Fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

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Cell

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Fos and jun repress transcription activation by NF-IL6 through association at the basic zipper region

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Molecular and Cellular Biology

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NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1

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Molecular and Cellular Biology

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Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells

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Molecular and Cellular Biology

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Nuclear signaling by interleukin-6

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Current Opinion in Immunology

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NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A

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Journal of Virology

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