National Taiwan University
Taipei, Taipei, Taiwan
→
Ph.D.
Microbiology
THE WENG LAB
Parasitology; Vector control; Vector-Borne Diseases; Synthetic Biology
R849 No.1 Jen Ai Road section 1 Taipei 100 Taiwan R.O.C., Ph: 886-2-23123456 ext. 288261; Email: scweng@ntu.edu.tw.About
Education
National Taiwan University
Taipei, Taipei, Taiwan
→
M.S.
Microbiology
National Dong-Hwa University
Hualien, Hualien, Taiwan
→
B.S.
Life Science
Academic and Professional Experience
National Taiwan University
|Assistant Professor
Taipei, Taipei, Taiwan
→
Summary
Leads pioneering research in tropical medicine and parasitology, focusing on developing novel genetic tools for mosquito control and advancing public health outcomes.
Highlights
Pioneer novel, effective technologies for mosquito population control, significantly enhancing public health outcomes by reducing the spread of mosquito-borne diseases.
Investigate the connection between sex-determining and sex-differentiation pathways in Aedes mosquitoes, aiming to uncover new key regulators involved in these processes.
Leverage prior experience in molecular virology to explore the viral life cycle and identify host factors specifically expressed in female mosquitoes, primary vectors of dengue virus.
Develop targeted control strategies aimed at reducing disease transmission while minimizing fitness costs in male mosquitoes that do not transmit diseases.
University of California San Diego
|Postdoctoral Scholar
San Diego, California, US
→
Summary
Developed high-throughput genetic sexing systems and conditional gene expression tools for advanced mosquito control strategies.
Highlights
Pioneered the development of high-throughput genetic sexing systems, successfully separating sexes in Aedes and Anopheles mosquitoes for targeted control strategies.
Engineered a conditional Nix expression system, effectively converting female mosquitoes to males under specific laboratory conditions.
Identified and targeted female-specific muscle genes to inhibit flight ability, a novel approach for female mosquito elimination in vector control.
Investigated sperm development essential genes to advance mosquito population suppression through sterile insect technique, contributing to public health initiatives.
Led numerous postdoctoral projects focused on developing advanced genetic tools, critically addressing pivotal challenges in mosquito-borne disease control.
National Taiwan University
|Postdoctoral Fellow
Taipei, Taipei, Taiwan
→
Summary
Conducted advanced research in tropical medicine and parasitology, focusing on vector control strategies and molecular mechanisms.
Highlights
Contributed significantly to cutting-edge research in tropical medicine and parasitology, enhancing understanding of vector-borne diseases.
National Taiwan University
|Research Assistant
Taipei, Taipei, Taiwan
→
Summary
Provided technical and research support for projects in tropical medicine and parasitology, ensuring efficient laboratory operations and data integrity.
Highlights
Executed comprehensive laboratory experiments, supporting research in tropical medicine and parasitology, and ensuring data integrity for publications.
Managed and maintained critical laboratory resources, including equipment and reagent inventories, optimizing research workflow efficiency.
Assisted in data collection, analysis, and preparation of research findings, contributing to multiple scientific publications.
Awards
Yushan Young Fellow
Ministry of Education
2030 Cross-Generation Emerging Young Scholar
National Science and Technology Council
Talent Recruitment Research Grant
National Taiwan University
World Mosquito Day campaign
Gene Drive Network
優秀論文競賽 特優 (Excellent Paper Award)
財團法人中華民國寄生蟲防治會 (Chinese Society of Parasitology)
醫學院微生物學研究所研究生成果優秀獎學金 (Outstanding Graduate Student Research Achievement Scholarship)
臺灣大學 (National Taiwan University)
范秉真教授研究論文獎 (Professor Bing-Zhen Fan Research Paper Award)
台灣寄生蟲學會 (Taiwan Society of Parasitology)
研究生優秀著作獎 (Outstanding Graduate Work Award)
臺灣大學 (National Taiwan University)
學生論文比賽 特優 (Student Paper Competition Excellence Award)
陳瑩霖教授暨寄生蟲防治會 (Professor Ying-Lin Chen and Parasitology Society)
Publications
Dual functions of the Aedes aegypti ecdysone receptor in dengue virus replication and reproduction control
Parasites & Vectors
A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito.
Cell
Morphological specializations of mosquito CO2-sensing olfactory receptor neurons.
Proc. Natl. Acad. Sci. U.S.A.
Establishing a dominant early larval sex selection strain in the Asian malaria vector Anopheles stephensi. First author.
Infectious Diseases of Poverty
Advances and challenges in synthetic biology for mosquito control. First author.
Trends in Parasitology
Efficient sex separation by exploiting differential alternative splicing of a dominant marker in Aedes aegypti. First author.
PLOS GENETICS
Co-infection of dengue and Zika viruses mutually enhances viral replication in the mosquito Aedes aegypti. First author.
Parasites & Vectors
The chaperone BiP promotes dengue virus replication and mosquito vitellogenesis in Aedes aegypti.
Insect Biochemistry and Molecular Biology
SUMOylation Is Essential for Dengue Virus Replication and Transmission in the Mosquito Aedes aegypti. First author.
Frontiers in Microbiology
A flavivirus-inducible gene expression system that modulates broad-spectrum antiviral activity against dengue and Zika viruses. First author.
Insect Biochemistry and Molecular Biology
Blood glucose promotes dengue virus infection in the mosquito Aedes aegypti. First author.
Parasites & Vectors
A Thioester-Containing Protein Controls Dengue Virus Infection in Aedes aegypti Through Modulating Immune Response. First author.
Frontiers in Immunology
A Simplified Method for Blood Feeding, Oral Infection, and Saliva Collection of the Dengue Vector Mosquitoes. First author.
PLoS One
The Unfolded Protein Response Modulates the Autophagy-Mediated Egg Production in the Mosquito Aedes aegypti. First author.
Insect Molecular Biology
DNA Topoisomerase IIIβ Promotes Cyst Generation by Inducing Cyst Wall Protein Gene Expression in Giardia lamblia.
Open Biology
Transcription Factor Elf3 Modulates Vasopressin-Induced Aquaporin-2 Gene Expression in Kidney Collecting Duct Cells.
Frontiers in Physiology
A Salivary Protein of Aedes aegypti Promotes dengue-2 Virus Replication and Transmission.
Insect Biochemistry and Molecular Biology
Novel phthalocyanines activated by dim light for mosquito larva- and cell-inactivation with inference for their potential as broad-spectrum photodynamic insecticides.
PLoS One
The Non-Canonical Notch Signaling Is Essential for the Control of Fertility in Aedes aegypti.
PLOS Neglected Tropical Diseases
A case of human infection with Anisakis simplex in Taiwan.
Gastrointestinal Endoscopy
Frizzled 2 is a key component in the regulation of TOR signaling-mediated egg production in the mosquito Aedes aegypti. First author.
Insect Biochemistry and Molecular Biology
DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lamblia.
PLOS Neglected Tropical Diseases
Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy.
Journal of Virology
Lab Members
Research Assistant
|Ho-An Chen
→
PhD student at NTU
|Yu-Chen Lee
→
Sep 2025 → Jan 2026, Research Assistant
PhD student at NTU
|Yu-Xian Zhou
→
Principal Investigator
|Shih-Che Weng
→