Yasuhide Morioka

Work

Shionogi Seiyaku Kabushiki Kaisha

Japan

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Shionogi Seiyaku Kabushiki Kaisha Iyaku Kenkyu Center

Japan

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Education

University of California San Diego
United States of America

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Kyoto Institute of Technology
Japan

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Publications

Incidence of opioid-induced constipation in non-cancer patients using weak opioids for chronic pain in Japan: a cohort study

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Scientific Reports

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Opioid prescription status around surgery, bone metastasis, or death events among patients with breast cancer in Japan: an analysis of the Japanese public health insurance comprehensive claims database (the National Database)

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Japanese Journal of Clinical Oncology

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Effect of add-on naldemedine treatment in patients with cancer and opioid-induced constipation insufficiently responding to magnesium oxide: a pooled, subgroup analysis of two randomized controlled trials

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Japanese Journal of Clinical Oncology

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The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty.

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Scientific reports

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Naldemedine and Magnesium Oxide as First-Line Medications for Opioid-Induced Constipation: A Comparative Database Study in Japanese Patients With Cancer Pain

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Cureus

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High prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: Combined database study and nationwide questionnaire survey in Japan

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Neuropsychopharmacology Reports

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High prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: Combined database study and nationwide questionnaire survey in Japan

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Neuropsychopharmacology Reports

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Real-World Evidence for the Safety and Effectiveness of Naldemedine in the Management of Opioid-Induced Constipation in Patients With Cancer Pain: Post-hoc Subgroup Analysis of Post-marketing Surveillance in Japan

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Cureus

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A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer

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Pain and Therapy

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A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer

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Pain and Therapy

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Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus

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Biological and Pharmaceutical Bulletin

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Opioid prescriptions at the point of surgery, bone metastasis, or death among patients with breast cancer in Japanese acute care hospitals: a claims-based, retrospective, longitudinal study

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Supportive Care in Cancer

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A Survey of the Incidence of Constipation in Patients with Chronic Non-cancer Pain Using Opioid Analgesics in Japan

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Pain and Therapy

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A Survey of the Incidence of Constipation in Patients with Chronic Non-cancer Pain Using Opioid Analgesics in Japan

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Pain and Therapy

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Role of transient receptor potential vanilloid 4 in therapeutic antifibrotic effects of pirfenidone

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American Journal of Physiology-Lung Cellular and Molecular Physiology

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Role of transient receptor potential vanilloid 4 in therapeutic antifibrotic effects of pirfenidone

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American Journal of Physiology-Lung Cellular and Molecular Physiology

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Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis

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PAIN Reports

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Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis

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PAIN Reports

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Selective blockade of transient receptor potential vanilloid 4 reduces cyclophosphamide-induced bladder pain in mice

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European Journal of Pharmacology

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Selective blockade of transient receptor potential vanilloid 4 reduces cyclophosphamide-induced bladder pain in mice

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European Journal of Pharmacology

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Involvement of the Peripheral mu-Opioid Receptor in Tramadol-Induced Constipation in Rodents

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Biological and Pharmaceutical Bulletin

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Pharmacological Profile of Naldemedine, a Peripherally Acting mu-Opioid Receptor Antagonist: Comparison with Naloxone and Naloxegol

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Journal of Pharmacology and Experimental Therapeutics

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Role of transient receptor potential vanilloid 4 in the therapeutic antifibrotic effects of pirfenidone

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European Respiratory Journal

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Analgesic effect of TRPV4 blockade on bladder pain in chronic cystitis mice

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PAIN RESEARCH

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Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors

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PAIN

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Pharmacologic effects of naldemedine, a peripherally acting mu-opioid receptor antagonist, in in vitro and in vivo models of opioid-induced constipation

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Neurogastroenterology and Motility

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Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats

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Brain Research

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Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain

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Brain and Neuroscience Advances

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Pharmacological Profile of Naldemedine, a Peripheral Acting mu-Opioid Receptor Antagonist : Comparison With Naloxone and Naloxegol

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The American Journal of Gastroenterology

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Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats withmonoiodoacetate-induced osteoarthritis

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PAIN

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The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice

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Pharmacology

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Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

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Bioorganic & Medicinal Chemistry

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Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

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Osteoarthritis and Cartilage

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Discovery of novel 2 ',4 '-dimethyl-[4,5 '-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1

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Bioorganic & Medicinal Chemistry Letters

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Discovery of novel 2 ',4 '-dimethyl-[4,5 '-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2

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Bioorganic & Medicinal Chemistry Letters

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Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model

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British Journal of Pharmacology

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S-777469, a Novel Cannabinoid Type 2 Receptor Agonist, Suppresses Itch-Associated Scratching Behavior in Rodents through Inhibition of Itch Signal Transmission

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Pharmacology

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G protein-gated inwardly rectifying potassium (K(IR)3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites

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British Journal of Pharmacology

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Hyaluronan digestion controls DC migration from the skin

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Journal of Clinical Investigation

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Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists

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Bioorganic & Medicinal Chemistry

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Selective CB2 agonists with anti-pruritic activity: Discovery of potent and orally available bicyclic 2-pyridones

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Bioorganic & Medicinal Chemistry

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CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: Reduction of CNS side effects by introducing polar functional groups

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Bioorganic & Medicinal Chemistry Letters

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Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent

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Bioorganic & Medicinal Chemistry Letters

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Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent

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Bioorganic & Medicinal Chemistry Letters

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2-Arylimino-5,6-dihydro-4<i>H</i>-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs

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Bioorganic & Medicinal Chemistry Letters

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Cathelicidin antimicrobial peptides inhibit hyaluronan-induced cytokine release and modulate chronic allergic dermatitis

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Journal of Investigative Dermatology

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2-Arylimino-5,6-dihydro-4<i>H</i>-1,3-thiazines as a new class of cannabinoid receptor agonists.: Part 2:: Orally bioavailable compounds

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Bioorganic & Medicinal Chemistry Letters

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2-arylimino-5,6-dihydro-4<i>H</i>-1,3-thiazines as a new class of cannabinoid receptor agonists.: Part 1:: Discovery of CB<sub>2</sub> receptor selective compounds

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Bioorganic & Medicinal Chemistry Letters

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Group X secretory phospholipase A(2) induces potent productions of various lipid mediators in mouse peritoneal macrophages

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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

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Mouse group X secretory phospholipase A(2) induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A(2) receptor

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Archives of Biochemistry and Biophysics

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Potential role of group X secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis

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FEBS Letters

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Purified group X secretory phospholipase A(2) induced prominent release of arachidonic acid from human myeloid leukemia cells

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Journal of Biological Chemistry

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Determination of uric acid in scalp hair for non-invasive evaluation of uricemic controls in hyperuricemia

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Biological and Pharmaceutical Bulletin

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Colorimetric determination of cystine (disulfide bond) in hair using dithiothreitol

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Biological and Pharmaceutical Bulletin

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Determination of sulfate-conjugated 3 beta-hydroxy bile acid in urine by HPLC with postcolumn fluorescence detection using an immobilized beta-hydroxysteroid dehydrogenase column

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Analytical Sciences

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