United Kingdom of Great Britain and Northern Ireland
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Imperial College London
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Group Leader
United Kingdom of Great Britain and Northern Ireland
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Imperial College London
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Edmond and Lily Safra Research Fellow
United Kingdom of Great Britain and Northern Ireland
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Imperial College London
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Advanced Research Fellow
United Kingdom of Great Britain and Northern Ireland
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University of California San Diego
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Assistant Project Scientist
US
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Massachusetts Institute of Technology
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Postdoctoral Associate
US
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University College London
United Kingdom of Great Britain and Northern Ireland
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Education
University College London
United Kingdom of Great Britain and Northern Ireland
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Ph.D.
University of Bath
United Kingdom of Great Britain and Northern Ireland
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MBiochem
Publications
Artificial intelligence for neurodegenerative experimental models
Published by
Alzheimer's and Dementia
Summary
journal-article
DAF-FM detection of nitric oxide in embryonic cortical neurons
Published by
Protocol exchange
Summary
journal-article
CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders
Published by
Cell Reports: Methods
Summary
journal-article
Enhanced differentiation of neural progenitor cells in Alzheimer’s disease into vulnerable immature neurons
Published by
iScience
Summary
journal-article
Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways
Published by
PLOS Genetics
Summary
journal-article
Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways
Published by
PLoS Genetics
Summary
journal-article
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders
Published by
Cell Systems
Summary
journal-article
CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks
Published by
Nature Communications
Summary
journal-article
CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks
Published by
Nature Communications
Summary
journal-article
Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes
Published by
Nature Genetics
Summary
journal-article
Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes
Published by
Nature Genetics
Summary
journal-article
Spatial mapping of Alzheimer’s disease across genetic subtypes
Published by
Nature Genetics
Summary
journal-article
Spatial mapping of Alzheimer's disease across genetic subtypes
Published by
Nature Genetics
Summary
journal-article
CHAS, A DECONVOLUTION TOOL, INFERS CELL TYPE-SPECIFIC SIGNATURES IN BULK BRAIN HISTONE ACETYLATION STUDIES OF BRAIN DISORDERS
Published by
European Neuropsychopharmacology
Summary
conference-paper
FANS Unfixed: Isolation and Proteomic Analysis of Mouse Cell Type-Specific Brain Nuclei
Published by
Journal of Proteome Research
Summary
journal-article
FANS unfixed: isolation and proteomic analysis of mouse cell type-specific brain nuclei
Published by
Journal of Proteome Research
Summary
journal-article
Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways
Summary
preprint
Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways
Summary
other
The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
Summary
journal-article
The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
Summary
preprint
Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types
Published by
Advances in neurobiology
Summary
journal-article
Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease
Published by
Frontiers in Immunology
Summary
journal-article
Artificial intelligence for neurodegenerative experimental models
Published by
Alzheimer's & Dementia
Summary
journal-article
Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome
Published by
eLife
Summary
journal-article
Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome
Published by
eLife
Summary
journal-article
Somatic mosaicism reveals clonal distributions of neocortical development
Published by
Nature
Summary
journal-article
CUT&Tag recovers up to half of ENCODE ChIP-seq peaks
Summary
online-resource
CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks
Summary
preprint
Label-free three-photon imaging of intact human cerebral organoids: tracking early events in brain development and deficits in Rett Syndrome
Summary
journal-article
Label-free three-photon imaging of intact human cerebral organoids: tracking early events in brain development and deficits in Rett Syndrome
Summary
preprint
CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders
Summary
journal-article
CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders
Summary
preprint
Nuclei isolation of multiple brain cell types for omics interrogation
Published by
Nature Protocols
Summary
journal-article
Nuclei isolation of multiple brain cell types for omics interrogation
Published by
Nature Protocols
Summary
journal-article
Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration
Published by
Molecular Systems Biology
Summary
journal-article
Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration
Published by
Molecular Systems Biology
Summary
journal-article
Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development
Summary
preprint
Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development
Summary
journal-article
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease
Published by
Nature Communications
Summary
journal-article
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
Summary
preprint
Brain cell type-specific enhancer-promoter interactome maps and disease-risk association
Published by
Science
Summary
journal-article
Brain cell type–specific enhancer–promoter interactome maps and disease - risk association
Published by
Science
Summary
journal-article
Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk association
Summary
journal-article
Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk association
Summary
other
Immune memory in the brain
Published by
Nature
Summary
journal-article
Immune memory in the brain
Published by
Nature
Summary
journal-article
A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development
Published by
Cell Reports
Summary
journal-article
A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development
Published by
Cell Reports
Summary
journal-article
Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling
Published by
Nature Neuroscience
Summary
journal-article
Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling
Published by
Nature Neuroscience
Summary
journal-article
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior
Published by
Nature Neuroscience
Summary
journal-article
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior
Published by
Nature Neuroscience
Summary
journal-article
S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration
Published by
Proceedings of the National Academy of Sciences of USA
Summary
journal-article
S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration
Published by
Proceedings of the National Academy of Sciences
Summary
journal-article
Decoding the S-nitroso proteome in a mouse model of Alzheimer's by SNOTRAP and mass spectrometry - clues for altered signaling pathways
Published by
ACS National Meeting Book of Abstracts
Summary
conference-paper
Activity-induced DNA breaks govern the expression of neuronal early-response genes
Published by
Cell
Summary
journal-article
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
Published by
Cell
Summary
journal-article
HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex
Published by
Neuroepigenetics
Summary
journal-article
HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex
Published by
Neuroepigenetics
Summary
journal-article
S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration
Published by
Proceedings of the National Academy of Sciences of USA
Summary
journal-article
HDAC Inhibitors as Novel Therapeutics in Aging and Alzheimer's Disease
Published by
EPIGENETIC REGULATION IN THE NERVOUS SYSTEM: BASIC MECHANISMS AND CLINICAL IMPACT
Summary
book-chapter
The Top3β way to untangle RNA
Published by
Nature Neuroscience
Summary
journal-article
List of Contributors
Published by
Epigenetic Regulation in the Nervous System
Summary
other
HDAC Inhibitors as Novel Therapeutics in Aging and Alzheimer’s Disease
Published by
Epigenetic Regulation in the Nervous System
Summary
other
The Top3β way to untangle RNA
Published by
Nat Neurosci
Summary
journal-article
List of Contributors
Summary
book-chapter
Nitric oxide-mediated epigenetic mechanisms in developing neurons
Published by
Cell Cycle
Summary
journal-article
Nitric Oxide-mediated epigenetic mechanisms in developing neurons
Published by
Cell Cycle
Summary
journal-article
S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons
Published by
Nature
Summary
journal-article
<i>S</i>-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons
Published by
Nature
Summary
journal-article
DAF-FM detection of nitric oxide in embryonic cortical neurons
Published by
Protocol Exchange
Summary
journal-article
Dorsal hippocampal α7 and α4β2 nicotinic receptors and memory
Published by
Brain Research
Summary
journal-article
Dorsal hippocampal α7 and α4β2 nicotinic receptors and memory