Guillaume Thibault

About

Guillaume Thibault PhD is a biochemist/cell biologist with 20 years of experience in cellular stress responses and quality control. He obtained his Ph.D. under the supervision of Prof Walid Houry from the Department of Biochemistry, University of Toronto, Canada. He was then a postdoc in Dr Davis Ng’s laboratory at Temasek Life Sciences Laboratory, Singapore. He joined the School of Biological Sciences (SBS) at Nanyang Technological University (NTU) to set up his research programme focusing on cellular stress and lipid homeostasis with funding from the prestigious Elite Nanyang Assistant Professorship Award and was subsequently promoted to Associate Professor (tenured). He secured more than S$ 3.3M in external funding as a principal investigator at SBS, NTU. He has published 33 papers and has an h-index of 19. He holds a joint appointment as co-Principal Investigator at the Mechanobiology Institute, National University of Singapore and as Adjunct Principal Investigator, Institute of Molecular and Cell Biology, A*STAR. He is also the founding President of the Society for Cell Biology Singapore (SCBS).

Work

Nanyang Technological University
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Associate Professor

Singapore

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Nanyang Technological University
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Associate Professor

Singapore

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National University of Singapore Mechanobiology Institute
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Co-Principal Investigator

Singapore

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National University of Singapore Mechanobiology Institute
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Co-Principal Investigator

Singapore

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Institute of Molecular and Cell Biology
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Adjunct Principal Investigator

Singapore

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Institute of Molecular and Cell Biology
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Adjunct Principal Investigator

Singapore

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Nanyang Technological University School of Biological Sciences
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Assistant Professor

Singapore

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Nanyang Technological University School of Biological Sciences
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Assistant Professor

Singapore

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Temasek Life Sciences Laboratory Ltd
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Research Fellow

Singapore

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Temasek Life Sciences Laboratory Ltd
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Research Fellow

Singapore

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Education

University of Toronto
Canada

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Ph.D. Biochemistry

University of Toronto
Canada

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Ph.D. Biochemistry

UQAM Faculté des Sciences
Canada

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B.Sc. Biochemistry

UQAM Faculté des Sciences
Canada

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B.Sc. Biochemistry

Publications

Enhanced nanoscale molecular dynamics mapping in live cells by galvo-accelerated single-molecule displacement analysis

Published by

Optica

Summary

journal-article

Choline intake during pregnancy influences maternal cognitive function and hippocampal gene expression in late adulthood

Published by

Nutritional Neuroscience

Summary

journal-article

Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age

Summary

preprint

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing

Summary

preprint

PlantConnectome: A knowledge graph database encompassing >71,000 plant articles

Published by

The Plant Cell

Summary

journal-article

Yeast Knowledge Graphs Database for Exploring Saccharomyces Cerevisiae and Schizosaccharomyces Pombe

Published by

Journal of Molecular Biology

Summary

journal-article

Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation

Summary

preprint

Yeast Knowledge Graphs Database for Exploring Saccharomyces Cerevisiae and Schizosaccharomyces Pombe

Published by

Journal of Molecular Biology

Summary

journal-article

Choline intake during pregnancy influences maternal cognitive function and hippocampal gene expression in late adulthood

Published by

Nutritional Neuroscience

Summary

journal-article

Yeast Knowledge Graphs Database for Exploring Saccharomyces Cerevisiae and Schizosaccharomyces Pombe

Published by

Journal of Molecular Biology

Summary

journal-article

Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age

Summary

preprint

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing

Summary

preprint

PlantConnectome: A knowledge graph database encompassing >71,000 plant articles

Published by

The Plant Cell

Summary

journal-article

Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation

Summary

preprint

Enhanced nanoscale molecular dynamics mapping in live cells by galvo-accelerated single-molecule displacement analysis

Published by

Optica

Summary

journal-article

Yeast Knowledge Graphs Database for Exploring Saccharomyces Cerevisiae and Schizosaccharomyces Pombe

Published by

Journal of Molecular Biology

Summary

journal-article

Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

Published by

eLife

Summary

journal-article

Yeast Knowledge Graphs Database for ExploringSaccharomyces cerevisiaeandSchizosaccharomyces pombe

Summary

preprint

Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

Published by

eLife

Summary

journal-article

A single-cell atlas of E. faecalis wound infection reveals novel bacterial-host immunomodulatory mechanisms

Summary

preprint

Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

Summary

preprint

Harnessing full-text publications for deep insights into C. elegans and Drosophila biomaps

Published by

BMC Genomics

Summary

journal-article

Harnessing full-text publications for deep insights intoC. elegansandDrosophilaconnectomes

Summary

preprint

Harnessing full-text publications for deep insights intoC. elegansandDrosophilaconnectomes

Summary

preprint

Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

Published by

eLife

Summary

journal-article

Yeast Knowledge Graphs Database for ExploringSaccharomyces cerevisiaeandSchizosaccharomyces pombe

Summary

preprint

PlantConnectome: knowledge graph encompassing >70,000 plant articles

Summary

preprint

PlantConnectome: knowledge graph encompassing >70,000 plant articles

Summary

preprint

Endoplasmic reticulum stress and lipids in health and diseases

Published by

Progress in Lipid Research

Summary

journal-article

Decoding the complexity of delayed wound healing followingEnterococcus faecalisinfection

Summary

preprint

Enabling open‐ended questions in team‐based learning using automated marking: Impact on student achievement, learning and engagement

Published by

Journal of Computer Assisted Learning

Summary

journal-article

Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism

Published by

Cell Reports

Summary

journal-article

A new combinatorial megaplasmid library assembly method designed to screen for minimal pathways by using SCRaMbLE

Summary

journal-article

The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

Published by

Nature Communications

Summary

journal-article

Human PERK rescues unfolded protein response-deficient yeast cells

Published by

microPublication Biology

Summary

journal-article

Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex

Published by

Nature Communications

Summary

journal-article

A high-throughput genetic screening protocol to measure lipid bilayer stress-induced unfolded protein response in Saccharomyces cerevisiae

Published by

STAR Protocols

Summary

journal-article

Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex

Published by

Nature Communications

Summary

journal-article

The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis

Published by

Journal of Cell Science

Summary

journal-article

Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Published by

Journal of Cell Biology

Summary

journal-article

Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis

Summary

preprint

Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes

Published by

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Summary

journal-article

Deuterated Polyunsaturated Fatty Acids Reduce Oxidative Stress and Extend the Lifespan of C. elegans

Published by

Frontiers in Physiology

Summary

journal-article

Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance.

Published by

Frontiers in cell and developmental biology

Summary

journal-article

ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Summary

other

Moving beyond the current limits of data analysis in longevity and healthy lifespan studies

Published by

Drug Discovery Today

Summary

journal-article

A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis.

Published by

Cell reports

Summary

journal-article

Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins

Published by

Scientific Reports

Summary

journal-article

Dropping in on lipid droplets: insights into cellular stress and cancer

Published by

Bioscience Reports

Summary

journal-article

Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

Published by

Journal of Cell Science

Summary

journal-article

Glucose increases the lifespan of post-reproductive C. elegans independently of FOXO

Summary

other

Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress

Summary

other

From the unfolded protein response to metabolic diseases – lipids under the spotlight

Published by

Journal of Cell Science

Summary

journal-article

Dropping in on lipid droplets: insights into cellular stress and cancer

Published by

Bioscience Reports

Summary

journal-article

A subset of UPR-induced transmembrane proteins are prematurely degraded during lipid perturbation

Summary

preprint

Endoplasmic Reticulum Stress Response in Yeast and Humans

Published by

Bioscience Reports

Summary

journal-article

F1000Prime Recommendation

Summary

book-review

Futile Protein Folding Cycles in the ER Are Terminated by the Unfolded Protein O-Mannosylation Pathway

Published by

Science

Summary

journal-article

The endoplasmic reticulum-associated degradation pathways of budding yeast

Published by

Cold Spring Harbor Perspectives in Biology

Summary

journal-article

Role of the N-terminal domain of the chaperone ClpX in the recognition and degradation of lambda phage protein O

Published by

Journal of Physical Chemistry B

Summary

other

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

Published by

Molecular Cell

Summary

journal-article

A screen for mutants requiring activation of the unfolded protein response for viability

Published by

Methods in Enzymology

Summary

journal-article

Linkage between the bacterial acid stress and stringent responses: The structure of the inducible lysine decarboxylase

Published by

EMBO Journal

Summary

journal-article

Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity

Published by

Journal of Biological Chemistry

Summary

journal-article

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

The AAA+ superfamily of functionally diverse proteins

Published by

Genome Biology

Summary

journal-article

Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Large nucleotide-dependent movement of the N-terminal domain of the ClpX chaperone

Published by

EMBO Journal

Summary

journal-article

The N-terminal zinc binding domain of ClpX is a dimerization domain that modulates the chaperone function.

Published by

The Journal of biological chemistry

Summary

journal-article