Hongying Shen

About

Hongying (Hoy) Shen is an assistant professor at Cellular & Molecular Physiology at Yale School of Medicine and Systems Biology Institute at Yale West Campus. Dr. Shen studies cellular metabolism, with a particular interest to harness the power of cutting-edge metabolomics to study metabolic pathways underlying human diseases, which would ultimately offer new directions for diagnostics and therapeutics. Prior to joining Yale, Hoy completed postdoctoral training with Dr. Vamsi Mootha at Massachusetts General Hospital (2019), where she developed metabolomics strategy to discover an uncharacterized enzyme CLYBL as a detoxification enzyme that protects vitamin B12. Hoy received her Ph.D. at Yale (2013), where she studied membrane trafficking with Dr. Pietro De Camilli (Yale Cell Biology and Neuroscience) and B.S. in chemistry from Nanjing University in China (2006). Hoy was awarded the NIH Pathway to the independence award (K99) from NIGMS, Chan Zuckerberg Initiative Neurodegeneration Pilot Awards (2020), Lois E. and Franklin H. Top, Jr., Scholar Award (2021), and Klingenstein-Simons Fellowship Award in Neurosciences (2021).

Work

Yale University School of Medicine
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Assistant Professor

US

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Publications

An in vivo screen identifies NAT10 as a master regulator of brain metastasis

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Science Advances

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journal-article

Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters

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Biomolecules

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journal-article

Enhanced access to the human phosphoproteome with genetically encoded phosphothreonine.

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Nature communications

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journal-article

Systems biochemistry to "deorphanize" human mitochondrial proteome.

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Molecular cell

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Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.

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Nature communications

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journal-article

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

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preprint

Salvage of Ribose from Uridine or RNA Supports Glycolysis when Glucose is Limiting

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preprint

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

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Journal of Cell Biology

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journal-article

VPS13D bridges the ER to mitochondria and peroxisomes via Miro.

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The Journal of cell biology

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journal-article

An IRON-clad Connection between Aging Organelles

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Cell

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journal-article

Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair.

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Science (New York, N.Y.)

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journal-article

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.

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Cell metabolism

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journal-article

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.

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Cell

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journal-article

A genetically encoded tool for manipulation of NADP+/NADPH in living cells.

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Nature chemical biology

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journal-article

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast.

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Molecular & cellular proteomics : MCP

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journal-article

Coupling between endocytosis and sphingosine kinase 1 recruitment.

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Nature cell biology

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journal-article

Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.

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Journal of cell science

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A multiple hypothesis based method for particle tracking and its extension for cell segmentation.

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Information processing in medical imaging : proceedings of the ... conference

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journal-article

SnapShot: membrane curvature sensors and generators.

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Cell

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journal-article

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.

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Proceedings of the National Academy of Sciences of the United States of America

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Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.

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Neuron

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An expectation maximization based method for subcellular particle tracking using multi-angle TIRF microscopy.

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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

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journal-article

Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.

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Molecular biology of the cell

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journal-article

Tracking clathrin coated pits with a multiple hypothesis based method.

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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

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journal-article

Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits.

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Developmental cell

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journal-article