Karen Liu

Work

King's College London

United Kingdom of Great Britain and Northern Ireland

King's College School
|

Professor of Genetics and Development

United Kingdom of Great Britain and Northern Ireland

King's College London
|

Reader in Signalling and Development

United Kingdom of Great Britain and Northern Ireland

Education

University of California, Berkeley
United States of America

PhD

Columbia College, Columbia University
United States of America

AB

Publications

The NuRD component CHD3 promotes BMP signalling during cranial neural crest cell specification

Published by

EMBO Reports

Summary

journal-article

The power of mouse models in the diagnostic odyssey of patients with rare congenital anomalies

Published by

Mammalian Genome

Summary

journal-article

The primary cilia: Orchestrating cranial neural crest cell development

Published by

Differentiation

Summary

journal-article

Neuroblastoma-associated ALK variants have distinct cellular and biochemical activities

Summary

preprint

Translating multiscale research in rare disease

Published by

Disease Models & Mechanisms

Summary

journal-article

Translating multiscale research in rare disease

Published by

Disease Models & Mechanisms

Summary

journal-article

Ciliary and non-ciliary functions of Rab34 during craniofacial bone development

Published by

Biochemical and Biophysical Research Communications

Summary

journal-article

Ciliary and non-ciliary functions of Rab34 during craniofacial bone development

Published by

Biochemical and Biophysical Research Communications

Summary

journal-article

The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP

Published by

Development (Cambridge, England)

Summary

journal-article

The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP

Published by

Development

Summary

journal-article

Cranial suture lineage and contributions to repair of the mouse skull

Published by

Development

Summary

journal-article

Cranial suture lineage and contributions to repair of the mouse skull

Published by

Development

Summary

journal-article

The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development

Published by

Journal of Anatomy

Summary

journal-article

The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development

Published by

Journal of Anatomy

Summary

journal-article

Beyond genomic studies of congenital heart defects through systematic modelling and phenotyping

Published by

Disease Models & Mechanisms

Summary

journal-article

The primary cilia: Orchestrating cranial neural crest cell development

Published by

Differentiation

Summary

journal-article

GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

Published by

Cell Reports

Summary

journal-article

GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

Published by

Cell Reports

Summary

journal-article

Identification of distinct subpopulations of Gli1‐lineage cells in the mouse mandible

Published by

Journal of Anatomy

Summary

journal-article

Identification of distinct subpopulations of Gli1-lineage cells in the mouse mandible

Published by

Journal of Anatomy

Summary

journal-article

The role of embryonic origins and suture proximity in repair of cranial bone

Summary

preprint

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Published by

Development

Summary

journal-article

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Published by

Development (Cambridge)

Summary

journal-article

Editorial

Published by

Frontiers in Cell and Developmental Biology

Summary

other

Identification of a novel variant of the ciliopathic gene FUZZY associated with craniosynostosis

Published by

European Journal of Human Genetics

Summary

journal-article

Linking neural crest development to neuroblastoma pathology

Published by

Development

Summary

journal-article

Linking neural crest development to neuroblastoma pathology

Published by

Development (Cambridge, England)

Summary

journal-article

Craniofacial dysmorphology in Down Syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Summary

preprint

GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

Summary

preprint

Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche

Published by

Biophysical Journal

Summary

journal-article

Anaplastic lymphoma kinase (alk), a neuroblastoma associated gene, is expressed in neural crest domains during embryonic development of Xenopus

Published by

Gene Expression Patterns

Summary

journal-article

Anaplastic lymphoma kinase (alk), a neuroblastoma associated gene, is expressed in neural crest domains during embryonic development of Xenopus

Published by

Gene Expression Patterns

Summary

journal-article

Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair

Published by

Nature Materials

Summary

journal-article

Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair

Published by

NATURE MATERIALS

Summary

journal-article

Differentiation of human induced pluripotent stem cells to the neural crest lineage

Published by

Advances in Stem Cell Biology: Current Progress in iPSC-derived Cell Types

Summary

book-chapter

Identification of a novel variant of the ciliopathic gene FUZZY associated with craniosynostosis

Published by

European Journal of Human Genetics

Summary

journal-article

Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer

Published by

International Journal of Molecular Sciences

Summary

journal-article

Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer

Published by

International Journal of Molecular Sciences

Summary

journal-article

Defining pathological activities of ALK in neuroblastoma, a neural crest-derived cancer

Published by

International Journal of Molecular Sciences

Summary

journal-article

Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome

Published by

Human Molecular Genetics

Summary

journal-article

Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche

Summary

preprint

Challenges and opportunities at the interface of birth defects, human genetics and developmental biology

Published by

Development

Summary

journal-article

Challenges and opportunities at the interface of birth defects, human genetics and developmental biology

Published by

Development (Cambridge, England)

Summary

journal-article

Editorial

Published by

Frontiers in Physiology

Summary

other

Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature

Published by

Development (Cambridge, England)

Summary

journal-article

Expression of the guanine nucleotide exchange factor, RAPGEF5, during mouse and human embryogenesis

Published by

Gene Expression Patterns

Summary

journal-article

Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature

Published by

Development

Summary

journal-article

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration

Published by

Journal of Visualized Experiments

Summary

journal-article

Induction of neural crest stem cells from Bardet-Biedl Syndrome patient derived hiPSCs

Published by

Frontiers in Molecular Neuroscience

Summary

journal-article

A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations

Published by

BIOMEDICAL MICRODEVICES

Summary

journal-article

G-Alpha Subunit Abundance and Activity Differentially Regulate β-Catenin Signaling

Published by

Molecular and Cellular Biology

Summary

journal-article

Diminution of pharyngeal segmentation and the evolution of the amniotes

Published by

Zoological letters

Summary

journal-article

The osteogenic potential of the neural crest lineage may contribute to craniosynostosis

Published by

Molecular syndromology

Summary

journal-article

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics

Published by

The EMBO journal

Summary

journal-article

ALK and GSK3

Published by

Journal of Experimental Neuroscience

Summary

journal-article

Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

Published by

Nature Communications

Summary

journal-article

RAPGEF5 regulates nuclear translocation of β-catenin

Published by

Developmental Cell

Summary

journal-article

ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells

Published by

Journal of Experimental Neuroscience

Summary

journal-article

The Stem Cell Niche: Interactions between Stem Cells and Their Environment

Published by

Stem Cells International

Summary

journal-article

The Stem Cell Niche

Published by

Stem cells international

Summary

other

Cilia-mediated hedgehog signaling controls form and function in the mammalian larynx

Published by

eLife

Summary

journal-article

Cilia-mediated hedgehog signaling controls form and function in the mammalian larynx

Published by

eLife

Summary

journal-article

Calvarial suture-derived stem cells and their contribution to cranial bone repair

Published by

Frontiers in Physiology

Summary

book-review

Frontal bone insufficiency in Gsk3β mutant mice

Published by

PLoS ONE

Summary

journal-article

Frontal bone insufficiency in Gsk3β mutant mice

Published by

PL o S One

Summary

journal-article

Micrognathia in mouse models of ciliopathies

Published by

Biochemical Society Transactions

Summary

journal-article

Micrognathia in mouse models of ciliopathies

Published by

Biochemical Society Transactions

Summary

journal-article

Small Molecule Inhibition of Transforming Growth Factor Beta Signaling Enables the Endogenous Regenerative Potential of the Mammalian Calvarium

Published by

Tissue Engineering - Part A

Summary

journal-article

Small Molecule Inhibition of Transforming Growth Factor Beta Signaling Enables the Endogenous Regenerative Potential of the Mammalian Calvarium

Published by

Tissue Engineering Part A

Summary

journal-article

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery

Published by

Nature Genetics

Summary

journal-article

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery

Published by

Nature Genetics

Summary

journal-article

Craniofacial Ciliopathies and the Interpretation of Hedgehog Signal Transduction

Published by

PLOS Genetics

Summary

journal-article

Craniofacial Ciliopathies and the Interpretation of Hedgehog Signal Transduction

Published by

PLoS Genetics

Summary

journal-article

Craniofacial Ciliopathies and the Interpretation of Hedgehog Signal Transduction

Published by

PL o S Genetics

Summary

other

Congenital tracheal defects: embryonic development and animal models

Published by

AIMS Genetics

Summary

journal-article

A novel ciliopathic skull defect arising from excess neural crest

Published by

Developmental Biology

Summary

journal-article

A novel ciliopathic skull defect arising from excess neural crest

Published by

Developmental Biology

Summary

journal-article

Animal models of craniofacial anomalies

Published by

Developmental Biology

Summary

journal-article

Animal models of craniofacial anomalies

Published by

Developmental Biology

Summary

other

Engineering FKBP-based destabilizing domains to build sophisticated protein regulation systems

Published by

PLoS ONE

Summary

journal-article

Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.

Published by

PLOS One

Summary

journal-article

Hedgehog activity controls opening of the primary mouth

Published by

Developmental Biology

Summary

journal-article

Hedgehog activity controls opening of the primary mouth

Published by

Developmental Biology

Summary

journal-article

Cranial neural crest cells form corridors prefiguring sensory neuroblast migration

Published by

Development (Cambridge): for advances in developmental biology and stem cells

Summary

journal-article

Fuz Mutant Mice Reveal Shared Mechanisms between Ciliopathies and FGF-Related Syndromes

Published by

Developmental Cell

Summary

journal-article

Common skeletal features in rare diseases

Published by

Rare Diseases

Summary

journal-article

Cranial neural crest cells form corridors prefiguring sensory neuroblast migration

Published by

Development (Cambridge)

Summary

journal-article

Fuz Mutant Mice Reveal Shared Mechanisms between Ciliopathies and FGF-Related Syndromes

Published by

Developmental Cell

Summary

journal-article

A lineage of myeloid cells independent of myb and hematopoietic stem cells

Published by

Science

Summary

journal-article

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Published by

Science

Summary

journal-article

Association of AXIN2 with non-syndromic oral clefts in multiple populations

Published by

Journal of Dental Research

Summary

journal-article

Association of AXIN2 with Non-syndromic Oral Clefts in Multiple Populations

Published by

Journal of Dental Research

Summary

journal-article

Future directions: Molecular approaches provide insights into palatal clefting and repair

Published by

Cleft Lip and Palate: Epidemiology, Aetiology and Treatment

Summary

book

Future directions

Published by

Frontiers of Oral Biology

Summary

book-chapter

Novel reporter alleles of GSK-3α and GSK-3β

Published by

PLoS ONE

Summary

journal-article

Novel Reporter Alleles of GSK-3α and GSK-3β

Published by

PLoS ONE

Summary

journal-article

Xenopus: An ideal system for chemical genetics

Published by

Genesis

Summary

journal-article

Novel Reporter Alleles of GSK-3 alpha and GSK-3 beta

Published by

PL o S One

Summary

journal-article

Xenopus: An ideal system for chemical genetics

Published by

GENESIS

Summary

journal-article

A lineage of myeloid cells independent of Myb and hematopoietic stem cells

Published by

Science

Summary

journal-article

Electroporation of craniofacial mesenchyme.

Published by

Journal of visualized experiments : JoVE

Summary

journal-article

Role of GSK-3β in the Osteogenic Differentiation of Palatal Mesenchyme

Published by

PL o S One

Summary

journal-article

Electroporation of craniofacial mesenchyme

Published by

Journal of Visualized Experiments

Summary

journal-article

Electroporation of craniofacial mesenchyme.

Published by

Journal of Visualized Experiments

Summary

journal-article

Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme

Published by

PLoS ONE

Summary

journal-article

Mesodermal Wnt signaling organizes the neural plate via Meis3

Published by

Development

Summary

journal-article

Xenopus

Published by

Current Biology

Summary

other

Mesodermal Wnt signaling organizes the neural plate via Meis3

Published by

Development

Summary

journal-article

Xenopus

Published by

Current Biology

Summary

journal-article

Mesodermal Wnt signaling organizes the neural plate via Meis3

Published by

Development (Cambridge): for advances in developmental biology and stem cells

Summary

journal-article

Neural crest origin of olfactory ensheathing glia

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Neural crest origin of olfactory ensheathing glia

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

New directions in craniofacial morphogenesis

Published by

Developmental Biology

Summary

journal-article

New directions in craniofacial morphogenesis

Published by

Developmental Biology

Summary

journal-article

New directions in craniofacial morphogenesis

Published by

Developmental Biology

Summary

journal-article

New roles for Gsk-3 beta and Wnts during skull vault osteogenesis

Published by

Genetics Research

Summary

journal-article

Xenopus

Published by

Current Biology

Summary

journal-article

Cranial Osteogenesis and Suture Morphology in Xenopus laevis: A Unique Model System for Studying Craniofacial Development

Published by

Plos One

Summary

journal-article

Cranial osteogenesis and suture morphology in Xenopus laevis: A unique model system for studying craniofacial development

Published by

PLoS ONE

Summary

journal-article

Cranial Osteogenesis and Suture Morphology in Xenopus laevis: A Unique Model System for Studying Craniofacial Development

Published by

PL o S One

Summary

journal-article

Dazap2 is required for FGF-mediated posterior neural patterning, independent of Wnt and Cdx function

Published by

Developmental Biology

Summary

journal-article

Dazap2 is required for FGF-mediated posterior neural patterning, independent of Wnt and Cdx function

Published by

Developmental Biology

Summary

journal-article

Dazap2 is required for FGF-mediated posterior neural patterning, independent of Wnt and Cdx function

Published by

Developmental Biology

Summary

journal-article

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development

Published by

Nature Cell Biology

Summary

journal-article

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development

Published by

Nature Cell Biology

Summary

journal-article

Tissue engineering in cleft palate and other congenital malformations

Published by

Pediatric Research

Summary

journal-article

Tissue turnover in the Xenopus laevis skull during metamorphosis

Published by

Journal of the American College of Surgeons

Summary

journal-article

Chemical rescue of cleft palate and midline defects in conditional GSK-3 beta mice

Published by

Nature

Summary

journal-article

Chemical rescue of cleft palate and midline defects in conditional GSK-3β mice

Published by

Nature

Summary

journal-article

Chemical rescue of cleft palate and midline defects in conditional GSK-3 beta mice

Published by

NATURE

Summary

journal-article

Discussion

Published by

Journal of Craniofacial Surgery

Summary

journal-article

Signaling via GSK-3 is required during midline skeletogenesis

Published by

Developmental Biology

Summary

journal-article

Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein

Published by

Development

Summary

journal-article

Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein

Published by

Development

Summary

journal-article

Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein

Published by

Development (Cambridge): for advances in developmental biology and stem cells

Summary

journal-article

Probing Wnt signaling using small molecule regulation of protein stability and localization.

Published by

Developmental Biology

Summary

journal-article

Cloning and characterization of Xenopus Id4 reveals differing roles for Id genes

Published by

Developmental Biology

Summary

journal-article

Cloning and characterization of Xenopus Id4 reveals differing roles for Id genes

Published by

Developmental Biology

Summary

journal-article

Cloning and characterization of Xenopus Id4 reveals differing roles for Id genes

Published by

Developmental Biology

Summary

journal-article

Use of large-scale expression cloning screens in the Xenopus laevis tadpole to identify gene function

Published by

Developmental Biology

Summary

journal-article

Use of large-scale expression cloning screens in the Xenopus laevis tadpole to identify gene function

Published by

Developmental Biology

Summary

journal-article

Use of large-scale expression cloning screens in the Xenopus laevis tadpole to identify gene function

Published by

Developmental Biology

Summary

journal-article