Kristen O'Connell

Evaluation of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spine structure in a translationally relevant AD mouse model

Jan 2025

preprint

An in vitro neurogenetics platform for precision disease modeling in the mouse

Science Advances

Jan 2024

journal-article

RNA Strain-Match: A tool for matching single-nucleus, single-cell, or bulk RNA-sequencing alignment data to its corresponding genotype

Jan 2023

preprint

Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model

Jan 2023

preprint

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

International Journal of Obesity

Jan 2023

journal-article

High Sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

Jan 2022

preprint

Hypothalamic gene network dysfunction is associated with cognitive decline and body weight loss in Alzheimer’s disease mice

Jan 2022

preprint

Life-long Dietary Restrictions have Negligible or Damaging Effects on Late-life Cognitive Performance: A Key Role for Genetics in Outcomes

Jan 2022

preprint

Anin vitroneurogenetics platform for precision disease modeling in the mouse

Jan 2022

preprint

High-fat diet induced loss of GABAergic inhibition decouples intrinsic and synaptic excitability in AgRP neurons

Jan 2021

other

Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice

Learning & Memory

Jan 2020

journal-article

Genetic background modifies CNS‐mediated sensorimotor decline in the AD‐BXD mouse model of genetic diversity in Alzheimer's disease

Genes, Brain and Behavior

Jan 2019

journal-article

Genetic background modifies CNS-mediated sensorimotor decline in the AD-BXD mouse population

Jan 2019

other

Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine.

Neuron

Jan 2018

journal-article

Cell-Type-Specific Changes in Intrinsic Excitability in the Subiculum following Learning and Exposure to Novel Environmental Contexts.

eNeuro

Jan 2018

journal-article

Human dental stem cell derived transgene-free iPSCs generate functional neurons via embryoid body-mediated and direct induction methods.

Journal of tissue engineering and regenerative medicine

Jan 2018

journal-article

Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice.

Scientific reports

Jan 2015

journal-article

Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus

Journal of Neuroscience

Jan 2014

journal-article

The C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel function.

Jan 2012

journal-article

Localization-dependent activity of the Kv2.1 delayed-rectifier K+ channel

Proceedings of the National Academy of Sciences

Jan 2010

journal-article

Localization and mobility of the delayed-rectifer K+ channel Kv2.1 in adult cardiomyocytes

AJP: Heart and Circulatory Physiology

Jan 2007

journal-article

A cytoskeletal-based perimeter fence selectively corrals a sub-population of cell surface Kv2.1 channels

Journal of Cell Science

Jan 2007

journal-article

Kv2.1 potassium channels are retained within dynamic cell surface microdomains that are defined by a perimeter fence.

Jan 2006

journal-article

Targeting of voltage-gated potassium channel isoforms to distinct cell surface microdomains.

Jan 2005

journal-article

Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling.

Jan 2004

journal-article

Localization of ion channels to lipid Raft domains within the cardiovascular system.

Jan 2004

journal-article

Targeting of ion channels to membrane microdomains: localization of KV channels to lipid rafts

Trends in Pharmacological Sciences

Jan 2004

journal-article

Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1.

Jan 2002

journal-article

Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes.

Jan 2002

journal-article

Ca2+ release through ryanodine receptors regulates skeletal muscle L-type Ca2+ channel expression.

Jan 2001

journal-article

Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes.

Jan 2000

journal-article