Luca Jovine

Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy

journal-article

Tracking Down the ZP Domain: From the Mammalian Zona Pellucida to the Molluscan Vitelline Envelope

journal-article

The ZP domain is a conserved module for polymerization of extracellular proteins

journal-article

Structural Characterization of Fish Egg Vitelline Envelope Proteins by Mass Spectrometry†

journal-article

Recent aspects of mammalian fertilization research

journal-article

Macromolecular mimicry in protein synthesis: beware of imitations

journal-article

Of crystals, structure factors and diffraction images

journal-article

Molecular beacons meet DNA–protein interactions: bye bye bandshift?

journal-article

ZONA PELLUCIDA DOMAIN PROTEINS

journal-article

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

other

Architecture of the vertebrate egg coat and structural basis of the ZP2 block to polyspermy

other

X-ray of fertilization

journal-article

Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats

journal-article

A simple technique to control macromolecular crystal nucleation efficiently using a standard vapour-diffusion setup

journal-article

Heavier weight on tubby

journal-article

Heavier weight on tubby

journal-article

Structural basis of ZP2-targeted immunocontraception

Jan 2025

preprint

Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia

Communications Biology

Jan 2025

journal-article

Uromodulin velcro sheets and their interaction with uropathogenic E. coli

Jan 2025

preprint

Structural basis of ZP2-targeted female nonhormonal contraception

Proceedings of the National Academy of Sciences

Jan 2025

journal-article

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

eLife

Jan 2024

journal-article

Mutations causing premature termination codons discriminate and generate cellular and clinical variability in HHT

Blood

Jan 2024

journal-article

Specifications of the ACMG/AMP Variant Curation Guidelines for Hereditary Hemorrhagic Telangiectasia Genes—ENG and ACVRL1

Human Mutation

Jan 2024

journal-article

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

eLife

Jan 2024

journal-article

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Jan 2024

preprint

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Jan 2024

preprint

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

eLife

Jan 2024

journal-article

ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

Cell

Jan 2024

journal-article

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

Jan 2023

preprint

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Jan 2023

preprint

Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries

Nature Communications

Jan 2023

journal-article

A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility.

Frontiers in cell and developmental biology

Jan 2022

journal-article

Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.

Nature structural & molecular biology

Jan 2022

journal-article

Complementing machine learning-based structure predictions with native mass spectrometry.

Protein science : a publication of the Protein Society

Jan 2022

journal-article

Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins.

Nature communications

Jan 2022

journal-article

Using machine learning to study protein–protein interactions: From the uromodulin polymer to egg zona pellucida filaments

Molecular Reproduction and Development

Jan 2021

journal-article

Mammalian egg coat modifications and the block to polyspermy

Molecular Reproduction and Development

Jan 2020

journal-article

Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer

bioRxiv

Jan 2020

preprint

Mutational and phenotypic characterisation of hereditary hemorrhagic telangiectasia.

Blood

Jan 2020

journal-article

Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.

The EMBO journal

Jan 2020

journal-article

Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition

IUCrJ

Jan 2019

journal-article

Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein

Scientific Reports

Jan 2019

journal-article

Characterization of a mutation in the zona pellucida module of Endoglin that causes Hereditary Hemorrhagic Telangiectasia

Gene

Jan 2019

journal-article

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Jan 2019

other

Crystal structure of mouse fetuin-B

Jan 2019

other

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Nature Communications

Jan 2019

journal-article

Structure of Zona Pellucida Module Proteins

Curr. Top. Dev. Biol.

Jan 2018

book-chapter

Revisiting embryo assisted hatching approaches: a systematic review of the current protocols

J. Assist. Reprod. Genet.

Jan 2018

journal-article

Structural Basis of Egg Coat-Sperm Recognition at Fertilization.

Jan 2017

journal-article

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.

Jan 2017

journal-article

Crystal structure of the zona pellucida module of human endoglin/CD105

Jan 2017

other

Crystal structure of the ZP-N1 domain of mouse sperm receptor ZP2 at 0.95 A resolution

Jan 2017

other

Crystal structure of human BMP9 at 1.87 A resolution

Jan 2017

other

ZP-N domain of mammalian sperm receptor ZP3 (crystal form II, processed in P21221)

Jan 2017

other

Crystal structure of the orphan region of human endoglin/CD105

Jan 2017

other

A structured interdomain linker directs self-polymerization of human uromodulin

Proceedings of the National Academy of Sciences

Jan 2016

journal-article

Crystal structure of Juno, the mammalian egg receptor for sperm Izumo1

Jan 2016

other

Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes.

Jan 2016

journal-article

Crystal structure of the ZP-C domain of mouse ZP2

Jan 2016

other

Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein

Jan 2016

other

The C-terminal region of OVGP1 remodels the zona pellucida and modifies fertility parameters.

Jan 2016

journal-article

The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins.

Jan 2016

journal-article

The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins

Current Biology

Jan 2016

journal-article

Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins

Journal of Structural Biology

Jan 2016

journal-article

The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.

Jan 2015

journal-article

The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

eLife

Jan 2015

journal-article

Deletion of the C-terminal region of OVGP1 affects porcine IVF

Reproduction Abstracts

Jan 2014

journal-article

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation

Acta Crystallogr. D Biol. Crystallogr.

Jan 2013

journal-article

Evolution of the Voltage Sensor Domain of the Voltage-Sensitive Phosphoinositide Phosphatase VSP/TPTE Suggests a Role as a Proton Channel in Eutherian Mammals

Mol. Biol. Evol.

Jan 2012

journal-article

Hedgehog signalling and cancer initiation

FEBS J.

Jan 2012

conference-abstract

A Structural View of Egg Coat Architecture and Function in Fertilization

Biol. Reprod.

Jan 2011

journal-article

The Molecular Basis of Sex: Linking Yeast to Human

Mol. Biol. Evol.

Jan 2011

journal-article

X-ray of fertilization

Mol. Reprod. Dev.

Jan 2011

journal-article

Crystal structure of full-length sperm receptor ZP3 at 2.0 A resolution

Jan 2010

other

Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution

Jan 2010

other

Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3

Cell

Jan 2010

journal-article

ZP-N domain of mammalian sperm receptor ZP3 (crystal form I)

Jan 2008

other

ZP-N domain of mammalian sperm receptor ZP3 (crystal form II)

Jan 2008

other

ZP-N domain of mammalian sperm receptor ZP3 (crystal form III)

Jan 2008

other

Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage

Biochem. Biophys. Res. Commun.

Jan 2008

journal-article

Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats

Nature

Jan 2008

journal-article

Of crystals, structure factors and diffraction images

J. Appl. Crystallogr.

Jan 2008

journal-article

Of crystals, structure factors and diffraction images

Journal of Applied Crystallography

Jan 2008

journal-article

Features that affect secretion and assembly of zona pellucida glycoproteins during mammalian oogenesis.

Jan 2007

journal-article

The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation

BMC Biochem.

Jan 2006

journal-article

Polypeptide encoded by mouse ZP3 exon-7 is necessary and sufficient for binding of mouse sperm in vitro

J. Cell. Physiol.

Jan 2006

journal-article

Tracking down the ZP domain: From the mammalian zona pellucida to the molluscan vitelline envelope

Semin. Reprod. Med.

Jan 2006

journal-article

Zona pellucida domain proteins

Annu. Rev. Biochem.

Jan 2005

journal-article

Recent aspects of mammalian fertilization research

Mol. Cell. Endocrinol.

Jan 2005

journal-article

Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg

J. Biol. Chem.

Jan 2005

journal-article

Egg-sperm interactions at fertilization in mammals

Eur. J. Obstet. Gynecol. Reprod. Biol.

Jan 2004

journal-article

Mouse zona pellucida genes and glycoproteins

Cytogenet. Genome Res.

Jan 2004

journal-article

A duplicated motif controls assembly of zona pellucida domain proteins

Proc. Natl. Acad. Sci. U. S. A.

Jan 2004

journal-article

Structural characterization of fish egg vitelline envelope proteins by mass spectrometry

Biochemistry

Jan 2004

journal-article

Structure, function and evolution of the signal recognition particle

Embo J.

Jan 2003

journal-article

Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle

Mol. Cell

Jan 2002

journal-article

Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear

BMC Cell Biol.

Jan 2002

journal-article

Macromolecular mimicry in protein synthesis: beware of imitations

Trends in Biotechnology

Jan 2002

journal-article

The ZP domain is a conserved module for polymerization of extracellular proteins

Nat. Cell Biol.

Jan 2002

journal-article

Heavier weight on tubby

Trends in Biotechnology

Jan 2001

journal-article

A profile of fertilization in mammals

Nat. Cell Biol.

Jan 2001

journal-article

New molecular beacons for targeting double-stranded DNA under native conditions

Trends Biotechnol.

Jan 2001

journal-article

Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA

Acta Crystallogr. Sect. D-Biol. Crystallogr.

Jan 2000

journal-article

The crystal structure of yeast phenylalanine tRNA at 2.0 angstrom resolution: Cleavage by Mg2+ in 15-year old crystals

J. Mol. Biol.

Jan 2000

journal-article

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region

FEBS Lett.

Jan 2000

journal-article

A simple technique to control macromolecular crystal nucleation efficiently using a standard vapour-diffusion setup

Journal of Applied Crystallography

Jan 2000

journal-article

Crystallization and preliminary X-ray analysis of the conserved domain IV of escherichia coli 4.5S RNA. erratum

Jan 2000

journal-article

The crystal structure of yeast phenylalanine tRNA at 2.0 Å resolution: cleavage by Mg2+ in 15-year old crystals

Journal of Molecular Biology

Jan 2000

journal-article

CRYSTAL STRUCTURE OF YEAST PHENYLALANINE TRANSFER RNA AT 2.0 A RESOLUTION

Jan 2000

other

A simple technique to control macromolecular crystal nucleation efficiently using a standard vapour-diffusion setup

J. Appl. Crystallogr.

Jan 2000

journal-article

Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

Structure

Jan 2000

journal-article

Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy

Structure

Jan 1996

journal-article

HUMAN U1A/U1A PRE-MRNA 3'UTR COMPLEX (THEORETICAL MODEL)

Jan 1996

other

Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy

Structure

Jan 1996

journal-article

Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.

Jan 1993

journal-article

Luca Jovine

Work

Karolinska Institutet

Karolinska Institutet

Karolinska Institutet

Education

Icahn School of Medicine at Mount Sinai

Università degli Studi di Milano

MRC Laboratory of Molecular Biology

Publications

Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy

Tracking Down the ZP Domain: From the Mammalian Zona Pellucida to the Molluscan Vitelline Envelope

The ZP domain is a conserved module for polymerization of extracellular proteins

Structural Characterization of Fish Egg Vitelline Envelope Proteins by Mass Spectrometry†

Recent aspects of mammalian fertilization research

Macromolecular mimicry in protein synthesis: beware of imitations

Of crystals, structure factors and diffraction images

Molecular beacons meet DNA–protein interactions: bye bye bandshift?

ZONA PELLUCIDA DOMAIN PROTEINS

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

Architecture of the vertebrate egg coat and structural basis of the ZP2 block to polyspermy

X-ray of fertilization

Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats

A simple technique to control macromolecular crystal nucleation efficiently using a standard vapour-diffusion setup

Heavier weight on tubby

Heavier weight on tubby

Structural basis of ZP2-targeted immunocontraception

Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia

Uromodulin velcro sheets and their interaction with uropathogenic E. coli

Structural basis of ZP2-targeted female nonhormonal contraception

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Mutations causing premature termination codons discriminate and generate cellular and clinical variability in HHT

Specifications of the ACMG/AMP Variant Curation Guidelines for Hereditary Hemorrhagic Telangiectasia Genes—ENG and ACVRL1

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries

A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility.

Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.

Complementing machine learning-based structure predictions with native mass spectrometry.

Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins.

Using machine learning to study protein–protein interactions: From the uromodulin polymer to egg zona pellucida filaments

Mammalian egg coat modifications and the block to polyspermy

Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer

Mutational and phenotypic characterisation of hereditary hemorrhagic telangiectasia.

Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.

Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition

Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein

Characterization of a mutation in the zona pellucida module of Endoglin that causes Hereditary Hemorrhagic Telangiectasia

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Crystal structure of mouse fetuin-B

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Structure of Zona Pellucida Module Proteins

Revisiting embryo assisted hatching approaches: a systematic review of the current protocols

Structural Basis of Egg Coat-Sperm Recognition at Fertilization.

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.

Crystal structure of the zona pellucida module of human endoglin/CD105

Crystal structure of the ZP-N1 domain of mouse sperm receptor ZP2 at 0.95 A resolution

Crystal structure of human BMP9 at 1.87 A resolution

ZP-N domain of mammalian sperm receptor ZP3 (crystal form II, processed in P21221)

Crystal structure of the orphan region of human endoglin/CD105

A structured interdomain linker directs self-polymerization of human uromodulin

Crystal structure of Juno, the mammalian egg receptor for sperm Izumo1

Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes.

Crystal structure of the ZP-C domain of mouse ZP2

Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein

The C-terminal region of OVGP1 remodels the zona pellucida and modifies fertility parameters.

The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins.

The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins

Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins

The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.

The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

Deletion of the C-terminal region of OVGP1 affects porcine IVF

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation

Evolution of the Voltage Sensor Domain of the Voltage-Sensitive Phosphoinositide Phosphatase VSP/TPTE Suggests a Role as a Proton Channel in Eutherian Mammals

Hedgehog signalling and cancer initiation