Prioritizing drug targets by perturbing biological network response functions
Published by
PLOS Computational Biology
Summary
journal-article
Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers
Published by
Annals of Surgical Oncology
Summary
journal-article
Triple negative breast tumors contain heterogeneous cancer cells expressing distinct KRAS-dependent collective and disseminative invasion programs
Published by
Oncogene
Summary
journal-article
A reciprocal translocation involving Aspergillus nidulans snxAHrb1/Gbp2 and gyfA uncovers a new regulator of the G2–M transition and reveals a role in transcriptional repression for the setBSet2 histone H3-lysine-36 methyltransferase
Published by
Genetics
Summary
journal-article
Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin
Published by
Science Translational Medicine
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journal-article
DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Published by
Clinical Cancer Research
Summary
journal-article
A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics
Published by
Bioorganic Chemistry
Summary
journal-article
Hyperglycemic conditions proliferate triple negative breast cancer cells: role of ornithine decarboxylase
Published by
Breast Cancer Research and Treatment
Summary
journal-article
Engineering a 3D collective cancer invasion model with control over collagen fiber alignment
Published by
Biomaterials
Summary
journal-article
An expanded universe of cancer targets
Published by
Cell
Summary
journal-article
Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia
Published by
Journal of Neuroinflammation
Summary
journal-article
Cancer cells educate natural killer cells to a metastasis-promoting cell state
Published by
Journal of Cell Biology
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journal-article
Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum
Published by
Journal of Biological Chemistry
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journal-article
Elevation of cellular Mg2+ levels by the Mg2+ transporter, Alr1, supports growth of polyamine-deficient Saccharomyces cerevisiae cells
Published by
Journal of Biological Chemistry
Summary
journal-article
DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer
Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies
Published by
PLOS ONE
Summary
journal-article
Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex
Published by
Human Molecular Genetics
Summary
journal-article
Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury