Ming Jiang

About

I had trained as a postdoctoral associate in Professor Pierre Chambon's Lab at IGBMC in France from 1999 to 2002, focusing on dissection of nuclear receptor RXRs and PPARs signaling pathways in the development and carcinogenesis in prostate, adipocyte, liver, and skin tissues and organs by an originally established inducible conditional Cre-ERT2/LoxP transgenic mouse model. I moved to Dr. Simon Hayward's Lab in Vanderbilt Prostate Cancer Center at Vanderbilt University Medical Center (VUMC), Nashville, TN, USA in 11/2002. I was promoted as a Research Assistant Professor of Urological Surgery in 2/2007 and then a Research Associate Professor of Medicine at VUMC in 1/2015. I am currently a Research Assistant Professor in Dr. Michael Savona's Lab in the Division of Hematology and Oncology, Department of Medicine at Vanderbilt-Ingram Cancer Center (VICC), VUMC. I am working on hematopoiesis and the biology of myeloid diseases including acute myeloid leukemia (AML), focusing on the research and development of novel oxidative phosphorylation (OxPhos) inhibitors in AML clinical. I am a biomedical research scientist special in cancer biopathology and translational medicine with extensive skills in establishment and characterization of primary culture cells, immortalized cell lines, 3D-organoid culture, patient-derived xenografting (PDX), and tissue recombination-xenografting (TRX) models in prostate, bladder, colorectal, and lung organs.

Work

Vanderbilt University Medical Center
|

Research Assistant Professor

US

Baylor College of Medicine
|

Assistant Professor

US

Vanderbilt University Medical Center
|

Research Assistant Professor

US

University of Kentucky
|

Temporary Professional Non-Administration

US

Vanderbilt University Medical Center
|

Research Associate Professor

US

Nantong University School of Medicine
|

Full Professor & Specially Appointed Professor

China

Vanderbilt University Medical Center
|

Research Assistant Professor

US

Nantong Medical College
|

Lecturer of Anatomy Pathology

China

Nantong Medical College
|

Teaching Assistant of Anatomy Pathology

China

Education

Vanderbilt University Medical Center
United States of America

Postdoctoral Research Fellow

Institut de Genetique et de Biologie Molecualre at Cellulaire (IGBMC)
France

Postdoctoral Researcher (Poste Vert)

Second Military Medical University
China

Postdoctoral Researcher

Shanghai Medical College, Fudan University
China

Ph.D.

Nantong University Medical School
China

M.S.

Nantong University Medical School
China

M.D.

Publications

Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury.

Published by

Nature medicine

Summary

journal-article

Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity

Published by

JCI Insight

Summary

journal-article

Cyclooxygenase-2 in adipose tissue macrophages limits adipose tissue dysfunction in obese mice

Published by

Journal of Clinical Investigation

Summary

journal-article

Triptonide acts as a novel antiprostate cancer agent mainly through inhibition of mTOR signaling pathway

Published by

The Prostate

Summary

journal-article

Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study

Published by

Molecular Carcinogenesis

Summary

journal-article

Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study

Published by

Molecular Carcinogenesis

Summary

journal-article

Inhibition of autophagy aggravated 4-nitrophenol-induced oxidative stress and apoptosis in NHPrE1 human normal prostate epithelial progenitor cells

Published by

Regulatory Toxicology and Pharmacology

Summary

journal-article

Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo

Published by

Oncotarget

Summary

journal-article

Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study

Published by

Molecular Carcinogenesis

Summary

journal-article

Infiltrating T Cells Promote Bladder Cancer Progression via Increasing IL1→Androgen Receptor→HIF1α→VEGFa Signals

Published by

Molecular Cancer Therapeutics

Summary

journal-article

Advances in prostate cancer research models: From transgenic mice to tumor xenografting models

Published by

Asian Journal of Urology

Summary

journal-article

Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

Published by

BMC Cancer

Summary

journal-article

Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two‐phase study

Published by

The FASEB Journal

Summary

journal-article

TR4 nuclear receptor enhances prostate cancer initiation via altering the stem cell population and EMT signals in the PPARG-deleted prostate cells

Published by

Oncoscience

Summary

journal-article

Functions of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gynecologic Disorders

Published by

Clinical Medicine Insights: Oncology

Summary

journal-article

Functions of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gynecologic Disorders

Published by

Clinical Medicine Insights: Oncology

Summary

journal-article

Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology

Published by

Asian Journal of Andrology

Summary

journal-article

ALCAM/CD166 Is a TGF-β–Responsive Marker and Functional Regulator of Prostate Cancer Metastasis to Bone

Published by

Cancer Research

Summary

journal-article

SPARCL1 suppresses metastasis in prostate cancer

Published by

Molecular Oncology

Summary

journal-article

Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium

Published by

The Prostate

Summary

journal-article

Deficiency in Metabolic Regulators PPARγ and PTEN Cooperates to Drive Keratinizing Squamous Metaplasia in Novel Models of Human Tissue Regeneration

Published by

The American Journal of Pathology

Summary

journal-article

Glandular Stem Cells (GSCs): Stem Cells in Glandular Organs

Published by

Stem Cells Handbook

Summary

book-chapter

The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor

Published by

Molecular and Cellular Biology

Summary

journal-article

PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation

Published by

Cell Death & Disease

Summary

journal-article

Suppressor role of androgen receptor in proliferation of prostate basal epithelial and progenitor cells

Published by

Journal of Endocrinology

Summary

journal-article

PPARγ: A molecular link between systemic metabolic disease and benign prostate hyperplasia

Published by

Differentiation

Summary

journal-article

Interplay between autophagy and metabolism in Ras mutation-induced tumorigenesis

Published by

Asian Journal of Andrology

Summary

journal-article

Altered TGF-β Signaling in a Subpopulation of Human Stromal Cells Promotes Prostatic Carcinogenesis

Published by

Cancer Research

Summary

journal-article

Disruption of PPARγ signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy

Published by

Cell Death & Differentiation

Summary

journal-article

Functional Remodeling of Benign Human Prostatic Tissues In Vivo by Spontaneously Immortalized Progenitor and Intermediate Cells

Published by

Stem Cells

Summary

journal-article

Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis

Published by

Autophagy

Summary

journal-article

Spontaneous immortalization of human dermal microvascular endothelial cells

Published by

World Journal of Stem Cells

Summary

journal-article

Activation of β-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration

Published by

The Prostate

Summary

journal-article

Methodologies in Assaying Prostate Cancer Stem Cells

Published by

Methods in Molecular Biology

Summary

book-chapter

Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells

Published by

Journal of Biological Chemistry

Summary

journal-article

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

Published by

Proceedings of the National Academy of Sciences

Summary

journal-article

Tissue-Specific Consequences of Cyclin D1 Overexpression in Prostate Cancer Progression

Published by

Cancer Research

Summary

journal-article

Malignant Transformation of DMBA/TPA-Induced Papillomas and Nevi in the Skin of Mice Selectively Lacking Retinoid-X-Receptor α in Epidermal Keratinocytes

Published by

Journal of Investigative Dermatology

Summary

journal-article

Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation

Published by

Development

Summary

journal-article

Functional role of RXRs and PPARγ in mature adipocytes

Published by

Prostaglandins, Leukotrienes and Essential Fatty Acids

Summary

journal-article

Approaches to understanding the importance and clinical implications of peroxisome proliferator-activated receptor gamma (PPARγ) signaling in prostate cancer

Published by

Journal of Cellular Biochemistry

Summary

journal-article

Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity

Published by

Proceedings of the National Academy of Sciences

Summary

journal-article

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes

Published by

Proceedings of the National Academy of Sciences

Summary

journal-article

Prognostic role of p27Kip1 and apoptosis in human breast cancer

Published by

British Journal of Cancer

Summary

journal-article

p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis

Published by

International Journal of Cancer

Summary

journal-article

In situ labeling apotosis in breast cancer as related to prognosis

Published by

Chinese Journal of Cancer Research

Summary

journal-article

Identification of spontaneous programmed cell death during development of human breast cancer

Published by

Oncology Reports

Summary

journal-article

Inhibition of apoptosis in human breast cancer as related to prognosis

Published by

Oncology Reports

Summary

journal-article