Highly accomplished and dedicated research scientist with over a decade of experience in Genetics, Bioinformatics, and Neuroscience, specializing in computational biology, statistical analysis, and AI/Machine Learning applications for biosciences. Proven expertise in next-generation sequencing, structural modeling, and drug design, contributing significantly to understanding complex biological systems and advancing therapeutic insights. Seeking to leverage extensive research background and advanced analytical skills in a senior research or development role within the biotechnology or pharmaceutical industry.
Fairfax, VA, USA
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Summary
Conducted molecular and computational research in Fly genetics and Developmental Neuroscience, investigating the role of neural networks in Drosophila development and behavior.
Highlights
Validated UAS RNAi constructs and performed large screens using Cell sorting and Immunohistochemistry (IHC) with live Confocal imaging.
Executed advanced statistical data analysis utilizing R (Bio-conductor module), PYTHON, TMev4, and GeneSpring GX 11 to interpret complex biological datasets.
Performed cloning, isolation experiments, larval dissection, and in vivo loss-of-function/gain-of-function analyses on genes impacting PNS and dendritic arborization.
Identified and validated several p-elements inhibiting behavioral aspects through a high-throughput miRNA screen and behavioral assay.
Not specified, Andhra Pradesh, INDIA
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Summary
Delivered comprehensive lecture series for undergraduate and postgraduate students in Bioinformatics, Drug Designing, and Biostatistics.
Highlights
Developed and delivered engaging lecture series on Bioinformatics and Introduction to Drug Designing for undergraduate students.
Taught advanced Biostatistics and Bioinformatics topics to postgraduate students, enhancing their analytical and computational skills.
Visakhapatnam, Andhra Pradesh, INDIA
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Summary
Coordinated and delivered graduate training and workshops focused on Biostatistics, Epidemiological Genetics, and advanced genetic analysis techniques.
Highlights
Led graduate training and workshops in Biostatistics and Epidemiological Genetics, equipping participants with essential research methodologies.
Conducted computational, statistical, and epidemiological genetic analysis utilizing MDR and LD methods for complex genetic studies.
Performed Gene and Allele frequency and RFLP analysis, contributing to fundamental genetic research and understanding.
Lead Bioinformatics & Computational Biology Researcher
Fairfax, VA, USA
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Summary
Led a bioinformatics research project focused on genome annotation of Mariprofundus ferroxydans pathways, identifying gene contigs for gluconeogenesis.
Highlights
Directed 'Genome Annotation of Mariprofundus ferroxydans pathways' project, identifying gene contigs encoding enzymes in the Gluconeogenesis pathway.
Conducted extensive gene-gene interaction studies for enzymes involved in Gluconeogenesis pathway and Glucose Metabolism.
Implemented data-driven approaches using PERL and PYTHON for robust bioinformatics analysis.
Performed structural modeling of proteins using Swiss-prot PDB-viewer, RASMOL, and PyMOL.
Graduate Research Assistant
Fairfax, VA, USA
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Summary
Conducted research in Breast Cancer Biology, investigating the tumor suppressor role of the KCNRG gene in CLL and MM.
Highlights
Investigated the KCNRG gene's role as a tumor suppressor in CLL and MM, aiming to elucidate its function in B-CLL disease progression.
Executed fundamental molecular biology techniques including gel electrophoresis, PCR, transfection, and E. coli transformation/cultivation.
Contributed to understanding tumorigenicity by analyzing the impact of KCNRG gene loss on B-cell Lymphocytes.
Chennai, Tamil Nadu, INDIA
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Summary
Led a graduate research project on "Infiltrating Ductal Carcinoma: Breast Cancer in Humans," focusing on identifying oncogenes and annotating the genome.
Highlights
Identified oncogenes and putative oncogenic markers in breast cancer using advanced Bioinformatics tools and packages.
Performed comprehensive structural analysis of polypeptide chains and their interactions using Swiss-prot PDB viewer and RASMOL.
Annotated Chromosome 17 contig of NM23 H1 and H2, including regulatory elements, to advance understanding of cancer genomics.
Awarded By
Virginia Academy of Sciences
Received the highest honor bestowed by the Virginia Academy of Sciences for outstanding research contributions.
Awarded By
Dept. Human Genetics & Molecular Genetics, Andhra University
Achieved 7th rank in a highly competitive university entrance examination for Human Genetics & Molecular Genetics.
Published by
PLoS ONE
Summary
Co-authored a publication detailing functional genomic analyses of Drosophila sensory neurons and the post-mitotic roles of transcription factors in dendritic patterning.
PERL, PYTHON, R (Bio-conductor), Statistical Data Analysis, Machine Learning, Artificial Intelligence (AI), Biostatistics, Epidemiological Genetics, MDR (Multifactor Dimensionality Reduction), LD Methods (Linkage Disequilibrium), TMev4, GeneSpring GX 11, HTML.
Next Generation Sequencing (NGS) Data Analysis, Genome Annotation, Gene Ontology (GSEA), Phylogenetic Analysis, Genome Databases, Nucleotide Databases, Protein Databases, Gene-Gene Interaction Studies, RFLP Analysis.
Cell Sorting Techniques, Immunohistochemistry (IHC), Confocal Imaging, Cloning, Isolation Experiments, Larval Dissection, In Vivo Loss-of-Function/Gain-of-Function Analysis, High-throughput miRNA Screen, Behavioral Assays, Gel Electrophoresis, PCR, Transfection, E. coli Transformation, Cell Cultivation.
Structural Modeling, SWISS-MODEL, NCBI's iCn3D, PyMol, RASMOL, AUTODOCK, AUTODOCK-Vina, Drug Designing, Docking Analysis.
Neuronal Dendritic Architecture Analysis, Neuromantic, Neurolucida Packages, Drosophila Genetics, Developmental Neuroscience.
Adobe Photoshop, Dreamweaver, Flash CS4.