C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models.
Published by
The Journal of clinical investigation
Summary
journal-article
Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief.
Published by
ACS pharmacology & translational science
Summary
journal-article
Regulating neuronal excitability: The role of S-palmitoylation in NaV1.7 activity and voltage sensitivity
Published by
PNAS Nexus
Summary
journal-article
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
Published by
Pain
Summary
journal-article
A new polymodal gating model of the proton-activated chloride channel.
Published by
PLoS biology
Summary
journal-article
Identification and targeting of a unique Na<sub>V</sub>1.7 domain driving chronic pain.
Published by
Proceedings of the National Academy of Sciences of the United States of America
Summary
journal-article
The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
Published by
British journal of pharmacology
Summary
journal-article
Argentatin C Analogues with Potential Antinociceptive Activity and Other Triterpenoid Constituents from the Aerial Parts of <i>Parthenium incanum</i>.
Published by
ACS omega
Summary
journal-article
A peptidomimetic modulator of the Ca<sub>V</sub>2.2 N-type calcium channel for chronic pain.
Published by
Proceedings of the National Academy of Sciences of the United States of America
Summary
journal-article
Breast cancer therapies reduce risk of Alzheimer's disease and promote estrogenic pathways and action in brain.
Published by
iScience
Summary
journal-article
The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state
Published by
Neuropharmacology
Summary
journal-article
Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain.
Published by
Pain
Summary
journal-article
Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca<sup>2+</sup> Channels and Pain.
Published by
ACS chemical neuroscience
Summary
journal-article
Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel
Published by
Channels
Summary
journal-article
Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents
Published by
Science Translational Medicine
Summary
journal-article
Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells
Published by
Stem Cell Reports
Summary
journal-article
Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry.
Published by
ACS chemical neuroscience
Summary
journal-article
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
Published by
Pain
Summary
journal-article
A modulator of the low-voltage-activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies.
Published by
Pain
Summary
journal-article
The role of cyclin-dependent kinase 5 in neuropathic pain.
Published by
Pain
Summary
journal-article
Druggability of CRMP2 for Neurodegenerative Diseases.
Published by
ACS chemical neuroscience
Summary
journal-article
Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.
Published by
Pain
Summary
journal-article
Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
Published by
Frontiers in molecular neuroscience
Summary
journal-article
The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.
Published by
ACS chemical neuroscience
Summary
journal-article
Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).
Published by
ACS chemical biology
Summary
journal-article
Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)
Published by
ACS Chemical Biology
Summary
journal-article
Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy
Published by
Pain
Summary
journal-article
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B)
Published by
ACS Chemical Biology
Summary
journal-article
Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.
Published by
Pain
Summary
journal-article
Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain
Published by
Pain
Summary
journal-article
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).
Published by
ACS chemical biology
Summary
journal-article
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.
Published by
Channels (Austin, Tex.)
Summary
journal-article
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels
Published by
Channels
Summary
journal-article
A novel variant in <i>TAF1</i> affects gene expression and is associated with X-linked <i>TAF1</i> intellectual disability syndrome.
Published by
Neuronal signaling
Summary
journal-article
Homology‐guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2‐derived peptides
Published by
British Journal of Pharmacology
Summary
journal-article
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides
Published by
British Journal of Pharmacology
Summary
journal-article
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function
Published by
Channels
Summary
journal-article
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function
Published by
Channels
Summary
journal-article
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of CRMP2-derived peptides.
Summary
journal-article
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.
Summary
journal-article
(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.
Summary
journal-article
(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5
Published by
Molecular Neurobiology
Summary
journal-article
Catalytic contribution of threonine 244 in human ALDH2
Published by
Chemico-Biological Interactions
Summary
journal-article
Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells.
Summary
journal-article
Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells
Published by
Protein Expression and Purification
Summary
journal-article
Catalytic contribution of threonine 244 in human ALDH2.
Published by
Chemico-biological interactions
Summary
journal-article
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.
Summary
journal-article
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases
Published by
Journal of Biological Chemistry
Summary
journal-article
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
Summary
journal-article
High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones
Published by
Protein Science
Summary
journal-article
High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones
Published by
Protein Science
Summary
journal-article
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant
Published by
Nature Structural and Molecular Biology
Summary
journal-article
Light Chain C-Terminal Region Reinforces the Stability of Clathrin Heavy Chain Trimers
Published by
Traffic
Summary
journal-article
Light chain C-terminal region reinforces the stability of clathrin heavy chain trimers
Published by
Traffic
Summary
journal-article
Coenzyme Isomerization Is Integral to Catalysis in Aldehyde Dehydrogenase†,‡
Published by
Biochemistry
Summary
journal-article
Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase
Published by
Biochemistry
Summary
journal-article
Three-dimensional structures of the three human class I alcohol dehydrogenases
Published by
Protein Science
Summary
journal-article
Three-dimensional structures of the three human class I alcohol dehydrogenases.
Summary
journal-article
Order and disorder in mitochondrial aldehyde dehydrogenase
Published by
Chemico-Biological Interactions
Summary
journal-article
Order and disorder in mitochondrial aldehyde dehydrogenase
Published by
Chemico-Biological Interactions
Summary
journal-article
Metastable states in classical and quantum systems