Vakhtang Barbakadze
About
Vakhtang Barbakadze has his expertise in isolation and structure elucidation of a new series of plant polyethers, which are endowed with pharmacological properties as immunomodulatory, antioxidant, antiinflammatory, wound-healing and anti-cancer agents. Besides, he interested in enantioselective synthesis and biological activities of basic monomeric moiety of these biopolyethers, synthesis of enantiomerically pure epoxides as chiral building blocks for the production of synthetic analogues of natural polyethers by chemical and enzymetic catalysis. He has received PhD degree in Chemistry and DSci degree in Biology in 1978 and 1999 from Institute of Organic Chemistry, Moscow, Russia and Institute of Biochemistry and Biotechnology, Tbilisi, Georgia, respectively. He is Head of the Department of Plant Biopolymers and Chemical Modification of Natural Compounds at Tbilisi State Medical University I.Kutateladze Institute of Pharmacochemistry. In 1996 and 2002 he has been a visiting scientist at Utrecht University, Departments of Pharmacognosy and Medicinal Chemistry, Utrecht, The Netherlands, by University Scholarship and The Netherlands organization for scientific research (NWO) Scholarship Scientific Program, respectively. He is also an organizing committee member and renowned speaker for many reputed scientific conferences. He has published more than 100 papers in reputed journals. In 2004 he was Georgian State Prize Winner in Science and Technology. 1 Patent P 2012 5391 B (Patents for inventions, NATIONAL INTELLECTUAL PROPERTY CENTER OF GEORGIA SAKPATENTI).
Work
Publications
POLYGLYCERIC ACID-BASED BIOPOLYMERS WITH NUMEROUS CATECHOL GROUPS ATTACHED: POLY [3-(3,4-DIHYDROXYPHENYL)GLYCERIC ACID] FROM MEDICINAL PLANTS OF BORAGINACEAE FAMILY WITH THERAPEUTIC EFFICACY
Published by
The 11th International scientific and practical conference “Modern problems of science, education and society” (January 8-10, 2024) SPC “Sci-conf.com.ua”, Kyiv, Ukraine. 2024.
Summary
conference-paper
SUGAR-BASED CATECHOL-CONTAINING BIOPOLYMERS: BIOLOGICALLY ACTIVE POLY[3-(3,4-DIHYDROXYPHENYL)GLYCERIC ACID] FROM MEDICINAL PLANTS OF BORAGINACEAE FAMILY WITH ANTICANCER EFFICACY, P. 4-7.
Published by
Importance of Soft Skills for Life and Scientific Success: Proceedings of the 2nd International Scientific and Practical Internet Conference, FOP Marenichenko V.V., Dnipro, Ukraine, 146 p.; Chemical sciences, International Electronic Scientific and Practical Journal “WayScience” (ISSN 2664-4819 (Online)
Summary
conference-paper
BIOLOGICALLY ACTIVE MULTICATECHOL-FUNCTIONAL POLY(2,3-GLYCERIC ACID ETHER)-BASED BIOPOLYMER: POLY[3-3,4-DIHYDROXYPHENYL) GLYCERIC ACID] FROM MEDICINAL PLANTS OF BORAGINACEAE FAMILY
Published by
The 12th International scientific and practical conference “Scientific research in the modern world” (September 21-23, 2023) Perfect Publishing, Toronto, Canada. 2023.
Summary
conference-paper
Carbohydrate-based Biopolymers: Biologically Active Poly[3-(3,4-Dihydroxyphenyl)Glyceric Acid] ―the Paradigm of a Multi-Target Biopolyether with Applications in Prostate Cancer Prevention and Treatment, P. 24-25.
Published by
Global Meet on Medicinal Chemistry, Drug Discovery & Drug Delivery April 17-19, 2023 | Osaka, Japan GMMCDD2023
Summary
conference-abstract
BIOLOGICALLY ACTIVE POLY[3-(3,4-DIHYDROXYPHENYL)GLYCERIC ACID] FROM THE STEMS OF PARACYNOGLOSSUM IMERETINUM (KUSN.) M.POP. (BORAGENACEAE). Abstract Book, Page 50.
Published by
International Scientific-Practical Conference "Georgian Scientific Pharmacy: Past and Present" dedicated to TSMU I.Kutateladze Institute of Pharmacochemistry 90th and Academician Iovel Kutateladze 135th anniversary, Tbilisi, Georgia, Tbilisi State Medical University, October 1-2, 2022.
Summary
conference-abstract
CARBOHYDRATE-BASED BIOPOLYMERS: BIOLOGICALLY ACTIVE POLY[3-(3,4-DIHYDROXYPHENYL)GLYCERIC ACID] FROM MEDICINAL PLANTS OF BORAGINACEAE FAMILY ― THE PARADIGM OF A MULTI-TARGET BIOPOLYETHER WITH APPLICATIONS IN CANCER PREVENTION AND TREATMENT, Abstract Book, Page 19.
Published by
International Scientific-Practical Conference "Georgian Scientific Pharmacy: Past and Present" dedicated to TSMU I.Kutateladze Institute of Pharmacochemistry 90th and Academician Iovel Kutateladze 135th anniversary, Tbilisi, Georgia, Tbilisi State Medical University, October 1-2, 2022.
Summary
conference-abstract
CAFFEIC ACID-DERIVED BIOPOLYETHER POLY[3-(3,4-DIHYDROXYPHENYL)GLYCERIC ACID], THE PARADIGM OF A MULTI-FUNCTIONAL BIOPOLYMER WITH ANTICANCER EFFICACY, Abstract Book, Page 176.
Published by
МАТЕРИАЛЫ XI МЕЖДУНАРОДНОГО СИМПОЗИУМА ФЕНОЛЬНЫЕ СОЕДИНЕНИЯ: ФУНДАМЕНТАЛЬНЫЕ И ПРИКЛАДНЫЕ АСПЕКТЫ. Институт физиологии растений им. К.А.Тимирязева РАН, 11 – 15 апреля 2022 года.
Summary
conference-abstract
Carbohydrate-Derived Biopolyethers: A Rare Representative of Poly(Sugar Acids) – Poly[3-(3,4-Dihydroxyphenyl) Glyceric Acid] from Medicinal Plants of Boraginaceae Family, its Synthetic Analogues and their Anticancer Efficacy
Published by
Global Summit and Expo on Biotechnology and Bioengineering GSEBB2021
Summary
conference-abstract
Carbohydrate-based biopolyethers: Anticancer poly[3-(3,4-dihydroxyphenyl)glyceric acid] from medicinal plants (Boraginaceae)
Published by
International scientific practical symposium ‘100 YEARS OF SUCCESS AND QUALITY’, dedicated to the 100th anniversary of Pharmaceutical Chemistry Department of the National University of Pharmacy
Summary
conference-abstract
Sugar Based Biopolymers: Novel Representative of Multifunctional Poly(Sugar Acids) - Poly[3-(3,4-Dihydroxyphenyl)Glyceric Acid] from Medicinal Plants of Boraginaceae Family, its Synthetic Analogues and their Therapeutic Efficacy
Published by
2nd Edition of Global Webinar on Plant Science and Research, Certificate.
Summary
conference-abstract
Poly(sugar acids): 3,4-dihydroxyphenyl derivative of acidic polysaccharide poly(2,3-glyceric acid ether) from medicinal plants of Boraginaceae family, its synthetic analogues and their therapeutic efficacy
Published by
Webinar on Microbial Biotechnology and Future Bioindustries
Summary
conference-abstract
Poly[3-(3,4-dihydroxy-phenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)
Published by
2nd International Conference on Natural Products and Physiologically Active Substances” (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry
Summary
conference-paper
Poly[3-(3,4-dihydroxy-phenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)
Published by
2nd International Conference on Natural Products and Physiologically Active Substances” (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry
Summary
conference-paper
Poly[3-(3,4-dihydroxy-phenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)
Published by
2nd International Conference on Natural Products and Physiologically Active Substances” (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry
Summary
conference-abstract
Biologically Active Polyethylene Glycol-Based Multiple-Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric acid] from Different Medicinal Plants of Boraginaceae Family.
Published by
Georgian Scientists, Vol. 7 Issue 2, 2025, https://doi.org/10.52340/gs.2025.07.02.43
Summary
High molecular weight (>1000 kDa or >500 kDa) water-soluble preparations (HMPs) from Symphytum asperum, S. caucasicum, S. officinale, S. grandiflorum, Anchusa italica, Cynoglossum officinale, Borago officinalis, and Paracynoglossum imeretinum (Boraginaceae) were obtained. The main chemical constituent of these HMPs is the first and only representative of a previously unreported class of natural polyethers — a novel poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], also known as poly[3-(3,4-dihydroxyphenyl)glyceric acid] (P-DGA). The structure elucidation of P-DGA was performed using data from various nuclear magnetic resonance (NMR) techniques, including liquid-state 1H, 13C NMR, two-dimensional (2D) homonuclear gCOSY, two-dimensional (2D) heteronuclear 1H/13C gHSQCED, two-dimensional (2D) DOSY (Diffusion-ordered spectroscopy), and solid-state 13C NMR spectra. The polyoxyethylene (polyethylene glycol) (PEG) chain serves as the backbone of this biopolymer, with a residue of 3-(3,4-dihydroxyphenyl)glyceric acid functioning as the repeating unit. The 3,4-dihydroxyphenyl (catechol) and carboxyl groups consistently substitute for two carbon atoms in the PEG backbone chain. Hence, P-DGA represents a unique class of natural polyethers. Each repeating trifunctional structural unit of P-DGA contains two phenolic hydroxyl groups in the ortho position and one carboxyl group. The multifunctionality of P-DGA likely explains its wide spectrum of biological activities, including anti-complementary, antioxidant, anti-inflammatory, burn and wound healing, antimicrobial, and anti-cancer properties.