WAI-LUN CHAN

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About

Kulice Wai-Lun Chan received his B.Sc. (Hons.) in Chemistry (2014) and M.A. in Communication (2015) from Hong Kong Baptist University, and Ph.D. in Chemistry (2019) from National University of Singapore. After the postdoctoral visiting (2020) at German Center for Neurodegenerative Diseases and Max Planck Institute for Biophysical Chemistry (renamed as Max Planck Institute for Multidisciplinary Sciences in 2022), he became a Research Assistant Professor (2021) at the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University; and served as a Research Associate Professor (2023) at the Advanced Manufacturing Center, Joint School of National University of Singapore and Tianjin University. Currently (2025), he works back as a Research Fellow at the Department of Pharmacy and Pharmceutical Sciences, National University of Singapore. His current interdisciplinary research interests include [1] asymmetric organocatalysis and site-selective chemical modification for complex natural product and targeted drug synthesis, and their late-stage functionalization; [2] photofunctional nanomaterials, supramolecular systems, metal complexes, and organic small molecules for photocatalytic and biomedical applications; [3] deep-learning-driven mRNA display technology for peptide-based drug discovery and catalyst development. #Organic Chemistry #Inorganic Chemistry #Supramolecular Chemistry #Chemical Biology #Medicinal Chemistry #Green Chemistry #Sustainable Chemistry #Synthetic Biology #Optical Spectroscopy #Nuclear Magnetic Resonance Spectroscopy #Artifical Intellegence #Machine Learning

Work

National University of Singapore

Research Fellow

, , Singapore

Feb 2025→ Present

Summary

Hong Kong Baptist University

Visiting Research Scholar

, , China

Oct 2023→ Aug 2025

Summary

National University of Singapore

Research Fellow

, , Singapore

Feb 2024→ Feb 2025

Summary

Joint School of National University of Singapore and Tianjin University

Research Associate Professor

, , China

Jan 2023→ Jul 2024

Summary

Hong Kong Polytechnic University

Research Assistant Professor

, , China

Jan 2021→ Jul 2022

Summary

German Center for Neurodegenerative Diseases

Postdoctoral Guest Scientist

, , Germany

Feb 2020→ Jan 2021

Summary

Hong Kong Baptist University

Postdoctoral Research Fellow

, , China

Jan 2020→ Dec 2020

Summary

Max Planck Institute for Biophysical Chemistry

Postdoctoral Guest Scientist

, , Germany

Feb 2020→ Jul 2020

Summary

Hong Kong Baptist University

Senior Research Assistant

, , China

Jul 2019→ Jan 2020

Summary

Hong Kong Polytechnic University

Research Assistant

, , China

Jul 2014→ Jun 2015

Summary

Hong Kong Baptist University

Junior Research Assistant

, , China

Jul 2012→ Jun 2014

Summary

Education

National University of Singapore

, , Singapore

Jul 2015→ Jun 2019

Ph.D. in Chemistry

Hong Kong Baptist University

, , Hong Kong

Sep 2014→ Jun 2015

M.A. in Communication

Hong Kong Baptist University

, , Hong Kong

Aug 2011→ Jun 2014

B.Sc. (Hons) in Chemistry

Publications

Late-Stage N-Alkenylative Modifications of Indolic Scaffolds with Propiolates: Toward Bisconjugation and Macrocyclization

Organic Letters

Jan 2025

journal-article

Recent advances in peptide macrocyclization strategies

Chemical Society Reviews

Jan 2024

journal-article

Efficacy and safety of innate and adaptive immunotherapy combined with standard of care in high-grade gliomas: a systematic review and meta-analysis

Frontiers in Immunology

Jan 2023

journal-article

Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin

Angewandte Chemie International Edition

Jan 2022

journal-article

Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin

Angewandte Chemie

Jan 2022

journal-article

Phosphine‐Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines

Angewandte Chemie International Edition

Jan 2022

journal-article

Phosphine‐Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines

Angewandte Chemie

Jan 2022

journal-article

(3 + 2) Cycloadditions by Nucleophilic Organocatalysis

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

Jan 2022

book-chapter

Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction

Angewandte Chemie

Jan 2021

journal-article

Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction

Angewandte Chemie International Edition

Jan 2021

journal-article

Dielectrophilic Allenic Ketone-Enabled [4 + 2] Annulation with 3,3’-Bisoxindoles: Enantioselective Creation of Two Contiguous Quaternary Stereogenic Centers

ACS Catalysis

Jan 2021

journal-article

Lanthanide–tetrapyrrole complexes: synthesis, redox chemistry, photophysical properties, and photonic applications

Chemical Society Reviews

Jan 2021

journal-article

Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction

Chemical Science

Jan 2020

journal-article

Solid-phase fluorescent BODIPY-peptide synthesis: Via in situ dipyrrin construction

Chemical Science

Jan 2020

journal-article

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Light: Science & Applications

Jan 2019

journal-article

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Light: Science and Applications

Jan 2019

journal-article

Phosphine-catalyzed (3+2) Annulation of Isoindigos with Allenes: Highly Enantioselective Creation of Two Vicinal Quaternary Stereogenic Centers

Angewandte Chemie International Edition

Jan 2019

journal-article

Phosphine-Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers

Angewandte Chemie - International Edition

Jan 2019

journal-article

Phosphine‐Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers

Angewandte Chemie

Jan 2019

journal-article

Creation of bispiro[pyrazolone-3,3′-oxindoles] via a phosphine-catalyzed enantioselective [3 + 2] annulation of the Morita–Baylis–Hillman carbonates with pyrazoloneyldiene oxindoles

Organic Chemistry Frontiers

Jan 2019

journal-article

Creation of bispiro[pyrazolone-3,3′-oxindoles]: Via a phosphine-catalyzed enantioselective [3 + 2] annulation of the Morita-Baylis-Hillman carbonates with pyrazoloneyldiene oxindoles

Organic Chemistry Frontiers

Jan 2019

journal-article

Phosphine-Catalyzed Asymmetric Organic Reactions

Chemical Reviews

Jan 2018

journal-article

Phosphine-Catalyzed Asymmetric Organic Reactions

Chemical Reviews

Jan 2018

journal-article

Enantioselective Construction of Bicyclic Pyran and Hydrindane Scaffolds via Intramolecular Rauhut–Currier Reactions Catalyzed by Thiourea-Phosphines

ACS Catalysis

Jan 2018

journal-article

Enantioselective Construction of Bicyclic Pyran and Hydrindane Scaffolds via Intramolecular Rauhut-Currier Reactions Catalyzed by Thiourea-Phosphines

ACS Catalysis

Jan 2018

journal-article

EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus

Nature Biomedical Engineering

Jan 2017

journal-article

EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein-Barr virus

Nature Biomedical Engineering

Jan 2017

journal-article

Urinary polyamines: A pilot study on their roles as prostate cancer detection biomarkers

PLoS ONE

Jan 2016

journal-article

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

Angewandte Chemie International Edition

Jan 2016

journal-article

Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers

PLOS ONE

Jan 2016

journal-article

Phosphine-mediated highly enantioselective spirocyclization with ketimines as substrates

Angewandte Chemie - International Edition

Jan 2016

journal-article

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

Angewandte Chemie

Jan 2016

journal-article

Highly enantioselective synthesis of dihydrocoumarin-fused dihydropyrans via the phosphine-catalyzed [4 + 2] annulation of allenones with 3-aroylcoumarins

Org. Biomol. Chem.

Jan 2016

journal-article

Highly enantioselective synthesis of dihydrocoumarin-fused dihydropyrans: Via the phosphine-catalyzed [4 + 2] annulation of allenones with 3-aroylcoumarins

Organic and Biomolecular Chemistry

Jan 2016

journal-article

Persistent Luminescence Nanomaterials for Biomedical Applications: A Quick Grasp of the Trend

Phosphors, Up Conversion Nano Particles, Quantum Dots and Their Applications

Jan 2016

other

Persistent luminescence nanomaterials for biomedical applications: A quick grasp of the trend

Phosphors, Up Conversion Nano Particles, Quantum Dots and Their Applications

Jan 2016

book-chapter

The reported anomalous emission intensity of the5D0→7F4transition of Eu3+in a molybdate double perovskite

J. Mater. Chem. C

Jan 2015

journal-article

Directional Plk1 inhibition-driven cell cycle interruption using amphiphilic thin-coated peptide-lanthanide upconversion nanomaterials as in vivo tumor suppressors

J. Mater. Chem. B

Jan 2015

journal-article

Directional Plk1 inhibition-driven cell cycle interruption using amphiphilic thin-coated peptide-lanthanide upconversion nanomaterials as in vivo tumor suppressors

Journal of Materials Chemistry B

Jan 2015

journal-article

The reported anomalous emission intensity of the ⁵D0 → ⁷F4 transition of Eu³⁺ in a molybdate double perovskite

Journal of Materials Chemistry C

Jan 2015

journal-article

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Chemical Communications

Jan 2014

journal-article

Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function

Organic & Biomolecular Chemistry

Jan 2014

journal-article

Monitoring and inhibition of Plk1: Amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function

Organic and Biomolecular Chemistry

Jan 2014

journal-article

Bifunctional up-converting lanthanide nanoparticles for selective in vitro imaging and inhibition of cyclin D as anti-cancer agents

J. Mater. Chem. B

Jan 2014

journal-article

Bifunctional up-converting lanthanide nanoparticles for selective in vitro imaging and inhibition of cyclin D as anti-cancer agents

Journal of Materials Chemistry B

Jan 2014

journal-article

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Chemical Communications

Jan 2014

journal-article

Real time detection of cell cycle regulator cyclin A on living tumor cells with europium emission

Dalton Transactions

Jan 2013

journal-article

Real time detection of cell cycle regulator cyclin A on living tumor cells with europium emission

Dalton Transactions

Jan 2013

journal-article

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Chemical Communications

Jan 2012

journal-article

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Chemical Communications

Jan 2012

journal-article

WAI-LUN CHAN

About

Work

National University of Singapore

Hong Kong Baptist University

National University of Singapore

Joint School of National University of Singapore and Tianjin University

Hong Kong Polytechnic University

German Center for Neurodegenerative Diseases

Hong Kong Baptist University

Max Planck Institute for Biophysical Chemistry

Hong Kong Baptist University

Hong Kong Polytechnic University

Hong Kong Baptist University

Education

National University of Singapore

Hong Kong Baptist University

Hong Kong Baptist University

Publications

Late-Stage N-Alkenylative Modifications of Indolic Scaffolds with Propiolates: Toward Bisconjugation and Macrocyclization

Recent advances in peptide macrocyclization strategies

Efficacy and safety of innate and adaptive immunotherapy combined with standard of care in high-grade gliomas: a systematic review and meta-analysis

Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin

Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin

Phosphine‐Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines

Phosphine‐Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines

(3 + 2) Cycloadditions by Nucleophilic Organocatalysis

Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction

Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction

Dielectrophilic Allenic Ketone-Enabled [4 + 2] Annulation with 3,3’-Bisoxindoles: Enantioselective Creation of Two Contiguous Quaternary Stereogenic Centers

Lanthanide–tetrapyrrole complexes: synthesis, redox chemistry, photophysical properties, and photonic applications

Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction

Solid-phase fluorescent BODIPY-peptide synthesis: Via in situ dipyrrin construction

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Phosphine-catalyzed (3+2) Annulation of Isoindigos with Allenes: Highly Enantioselective Creation of Two Vicinal Quaternary Stereogenic Centers

Phosphine-Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers

Phosphine‐Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers

Creation of bispiro[pyrazolone-3,3′-oxindoles] via a phosphine-catalyzed enantioselective [3 + 2] annulation of the Morita–Baylis–Hillman carbonates with pyrazoloneyldiene oxindoles

Creation of bispiro[pyrazolone-3,3′-oxindoles]: Via a phosphine-catalyzed enantioselective [3 + 2] annulation of the Morita-Baylis-Hillman carbonates with pyrazoloneyldiene oxindoles

Phosphine-Catalyzed Asymmetric Organic Reactions

Phosphine-Catalyzed Asymmetric Organic Reactions

Enantioselective Construction of Bicyclic Pyran and Hydrindane Scaffolds via Intramolecular Rauhut–Currier Reactions Catalyzed by Thiourea-Phosphines

Enantioselective Construction of Bicyclic Pyran and Hydrindane Scaffolds via Intramolecular Rauhut-Currier Reactions Catalyzed by Thiourea-Phosphines

EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus

EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein-Barr virus

Urinary polyamines: A pilot study on their roles as prostate cancer detection biomarkers

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers

Phosphine-mediated highly enantioselective spirocyclization with ketimines as substrates

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

Highly enantioselective synthesis of dihydrocoumarin-fused dihydropyrans via the phosphine-catalyzed [4 + 2] annulation of allenones with 3-aroylcoumarins

Highly enantioselective synthesis of dihydrocoumarin-fused dihydropyrans: Via the phosphine-catalyzed [4 + 2] annulation of allenones with 3-aroylcoumarins

Persistent Luminescence Nanomaterials for Biomedical Applications: A Quick Grasp of the Trend

Persistent luminescence nanomaterials for biomedical applications: A quick grasp of the trend

The reported anomalous emission intensity of the5D0→7F4transition of Eu3+in a molybdate double perovskite

Directional Plk1 inhibition-driven cell cycle interruption using amphiphilic thin-coated peptide-lanthanide upconversion nanomaterials as in vivo tumor suppressors

Directional Plk1 inhibition-driven cell cycle interruption using amphiphilic thin-coated peptide-lanthanide upconversion nanomaterials as in vivo tumor suppressors

The reported anomalous emission intensity of the 5D0 → 7F4 transition of Eu3+ in a molybdate double perovskite

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function

Monitoring and inhibition of Plk1: Amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function

Bifunctional up-converting lanthanide nanoparticles for selective in vitro imaging and inhibition of cyclin D as anti-cancer agents

Bifunctional up-converting lanthanide nanoparticles for selective in vitro imaging and inhibition of cyclin D as anti-cancer agents

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Real time detection of cell cycle regulator cyclin A on living tumor cells with europium emission

Real time detection of cell cycle regulator cyclin A on living tumor cells with europium emission

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

The reported anomalous emission intensity of the ⁵D0 → ⁷F4 transition of Eu³⁺ in a molybdate double perovskite